2024

最新文章

• Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering AI翻译
  作者：Lieberthal, Tyler J.; Sahakyants, Tatevik; Szabo-Wexler, Naomi R.; Hancock, Matthew J.; Spann, Andrew P.; Oliver, Mark S.; Grindy, Scott C.; Neville, Craig M.; Vacanti, Joseph P.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
  摘要：This study presents the design, fabrication, and evaluation of a general platform for the creation of three- dimensional printed devices (3DPDs) for tissue engineering applications. As a demonstration, we modeled the liver with 3DPDs consisting of a pair of parallel millifluidic channels that function as portal- venous (PV) and hepatobiliary (HB) structures. Perfusion of medium or whole blood through the PV channel supports the hepatocyte- containing HB channel. Device computer- aided design w...
• Molecular signaling predicts corticospinal axon growth state and muscle response plasticity induced by neuromodulation AI翻译
  作者：Zareen, Neela; Yung, Halley; Kaczetow, Walter; Glattstein, Aliya; Mazalkova, Ekaterina; Alexander, Heather; Chen, Liang; Parra, Lucas C.; Martin, John H.
  作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System
  摘要：Electrical motor cortex stimulation can produce corticospinal system plasticity and enhance motor function after injury. We investigate molecular mechanisms of structural and physiological plasticity following electrical neuromodulation, focusing on identifying molecular predictors, or biomarkers, for durable plasticity. We used two neuromodulation protocols, repetitive multipulse stimulation (rMPS) and patterned intermittent theta burst stimulation (iTBS), incorporating different stimulation ...
• Path dependence, stigmergy, and memetic reification in the formation of the 27 Club myth AI翻译
  作者：Dunivin, Zackary Okun; Kaminski, Patrick
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Stuttgart
  摘要：The 27 Club refers to the widespread legend that notable people, particularly musicians, are unusually likely to die at age 27. A 2011 inquiry in The BMJ showed this is not the case, dismissing the 27 Club as a myth. We expand on this discourse by demonstrating that although the existence of the phenomenon cannot be empirically validated, it is real in its consequences. Using Wikipedia data, we show that while age 27 does not hold greater risk of mortality for notable persons, those who died a...
• Lithium isotope evidence for a plumeworld ocean in the aftermath of the Marinoan snowball Earth AI翻译
  作者：Gan, Tian; Tian, Meng; Wang, Xi-Kai; Wang, Shijie; Liu, Xiao-Ming; Jiang, Ganqing; Gill, Benjamin C.; Nolan, Morrison; Kaufman, Alan J.; Luo, Taiyi; Xiao, Shuhai
  作者单位：Chinese Academy of Sciences; Institute of Geochemistry, CAS; Virginia Polytechnic Institute & State University; University System of Maryland; University of Maryland College Park; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Bern; University of Munich; University of North Carolina; University of North Carolina Chapel Hill; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University System of Ohio; Denison University; University System of Maryland; University of Maryland College Park; Chinese Academy of Sciences; Institute of Geochemistry, CAS
  摘要：The snowball Earth hypothesis predicts that continental chemical weathering diminished substantially during, but rebounded strongly after, the Marinoan ice age some 635 Mya. Defrosting the planet would result in a plume of fresh glacial meltwater with a different chemical composition from underlying hypersaline seawater, generating both vertical and lateral salinity gradients. Here, we test the plumeworld hypothesis using lithium isotope compositions in the Ediacaran Doushantuo cap dolostone t...
• Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy AI翻译
  作者：Mourad, Nizar I.; Perota, Andrea; Xhema, Daela; Duchi, Roberto; Lagutina, Irina; Galli, Cesare; Gianello, Pierre
  作者单位：Universite Catholique Louvain
  摘要：To be clinically efficient, beta cell replacement therapies such as pig islet xenotransplantation must ensure sufficient insulin secretion from grafted islets. While protection from host immune reaction is essential for islet engraftment and their subsequent functioning, intrinsic physiological properties of used cells are also a key factor. We have previously shown that islets with adenoviral- mediated expression of a dipeptidyl peptidase- resistant form of glucagon-like- peptide- 1 (GLP-1) a...
• Formylation facilitates the reduction of oxidized initiator methionines AI翻译
  作者：Tan, Ruiyue; Hoare, Margaret; Bellomio, Philip; Broas, Sarah; Camacho, Konttessa; Swovick, Kyle; Welle, Kevin A.; Hryhorenko, Jennifer R.; Ghaemmaghami, Sina
  作者单位：University of Rochester; University of Rochester
  摘要：Within a cell, protein- bound methionines can be chemically or enzymatically oxidized, and subsequently reduced by methionine sulfoxide reductases (Msrs). Methionine oxidation can result in structural damage or be the basis of functional regulation of enzymes. In addition to participating in redox reactions, methionines play an important role as the initiator residue of translated proteins where they are commonly modified at their alpha- amine group by formylation or acetylation. Here, we inve...
• Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling AI翻译
  作者：Duan, Weicheng; Huang, Guiyang; Sui, Yang; Wang, Kang; Yu, Yuxin; Chu, Xufeng; Cao, Xu; Chen, Liangpei; Liu, Jiahui; Eichler, Evan E.; Xiong, Bo
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; University of Washington; University of Washington Seattle; Nanjing Medical University; Huazhong University of Science & Technology; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Huazhong University of Science & Technology
  摘要：The molecular mechanisms underlying the neurodevelopmental disorders (NDDs) caused by DDX3X variants remain poorly understood. In this study, we validated that de novo DDX3X variants are enriched in female developmental delay (DD) patients and mainly affect the evolutionarily conserved amino acids based on a meta- analysis of 46,612 NDD trios. We generated a ddx3x deficient zebrafish allele, which exhibited reduced survival rate, DD, microcephaly, adaptation defects, anxiolytic behaviors, soci...
• Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive AI翻译
  作者：Hua, Yu; Zhang, Jianxiu; Yang, Man- Yun; Ren, Jing- Yi; Suo, Fang; Liang, Lingfei; Dong, Meng- Qiu; Ye, Keqiong; Du, Li - Lin
  作者单位：National Institute of Biological Sciences, Beijing; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University
  摘要：In sexual reproduction, selfish genetic elements known as killer meiotic drivers (KMDs) bias inheritance by eliminating gametes that do not carry them. The selective killing behavior of most KMDs can be explained by a toxin-antidote model, where a toxin harms all gametes while an antidote provides resistance to the toxin in carriers. This study investigates whether and how the KMD element tdk1 in the fission yeast Schizosaccharomyces pombe deploys this strategy. Intriguingly, tdk1 relies on a ...
• AMBRA1 controls the translation of immune- specific genes in T lymphocytes AI翻译
  作者：Gottlieb, Simone; Shang, Wanjing; Ye, Deji; Kubo, Satoshi; Jiang, Ping Du; Shafer, Samantha; Xu, Leilei; Zheng, Lixin; Park, Ann Y.; Song, Jian; Chan, Waipan; Zeng, Zhiqin; He, Tingyan; Schwarz, Benjamin; Haeupl, Bjoern; Oellerich, Thomas; Lenardo, Michael J.; Yao, Yikun
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; University of Occupational & Environmental Health - Japan; Shenzhen Children's Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Goethe University Frankfurt
  摘要：T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. Using a whole- genome CRISPR screen for regulators of CD95 (FAS/APO-1)- mediated T cell death, we identified AMBRA1, a protein previously studied for its roles in autophagy, E3 ubiquitin ligase activity, and cyclin regulation. T cells lacking AMBRA1 resisted FAS- mediated...
• Regional specialization, polyploidy, and seminal fluid transcripts in the Drosophila female reproductive tract AI翻译
  作者：Thayer, Rachel C.; Polston, Elizabeth S.; Xu, Jixiang; Begun, David J.
  作者单位：University of California System; University of California Davis
  摘要：Sexual reproduction requires the choreographed interaction of female cells and molecules with sperm and seminal fluid. In internally fertilizing animals, these interactions are managed by specialized tissues within the female reproductive tract (FRT), such as a uterus, glands, and sperm storage organs. However, female somatic reproductive tissues remain understudied, hindering insight into the molecular interactions that support fertility. Here, we report the identification, molecular characte...