-
作者：Webber, Quinn
作者单位：University of Guelph
-
作者：Kim, Yeon Jin; Packer, Orin; Dacey, Dennis M.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：The neural pathways that start human color vision begin in the complex synaptic network of the foveal retina where signals originating in long (L), middle (M), and short (S) wavelength- sensitive cone photoreceptor types are compared through antagonistic interactions, referred to as opponency. In nonhuman primates, two cone opponent pathways are well established: an L vs. M cone circuit linked to the midget ganglion cell type, often called the red- green pathway, and an S vs. L + M cone circui...
-
作者：Guan, Xingyue; Tang, Qian-Yuan; Ren, Weitong; Chen, Mingchen; Wang, Wei; Wolynes, Peter G.; Li, Wenfei
作者单位：Nanjing University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hong Kong Baptist University; Changping Laboratory; Rice University
摘要：Proteins perform their biological functions through motion. Although high throughput prediction of the three-dimensional static structures of proteins has proved feasible using deep-learning-based methods, predicting the conformational motions remains a challenge. Purely data-driven machine learning methods encounter difficulty for addressing such motions because available laboratory data on conformational motions are still limited. In this work, we develop a method for generating protein allo...
-
作者：Liu, Kaien; Tao, Youqi; Zhao, Qinyue; Xia, Wencheng; Li, Xiang; Zhang, Shenqing; Yao, Yuxuan; Xiang, Huaijiang; Han, Chao; Tan, Li; Sun, Bo; Li, Dan; Li, Ang; Liu, Cong
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
摘要：alpha- synuclein (alpha- syn) assembles into structurally distinct fibril polymorphs seen in different synucleinopathies, such as Parkinson's disease and multiple system atrophy. Targeting these unique fibril structures using chemical ligands holds diagnostic significance for different disease subtypes. However, the molecular mechanisms governing small molecules interacting with different fibril polymorphs remain unclear. Here, we investigated the interactions of small molecules belonging to f...
-
作者：Dittman, Jeremy S.
作者单位：Cornell University; Weill Cornell Medicine
-
作者：Leeuwis, Matto; Asar, Yomna; White, Joshua J.; Rasman, Brandon G.; Forbes, Patrick A.
作者单位：Erasmus University Rotterdam; Erasmus MC; Radboud University Nijmegen
摘要：Human standing balance relies on the continuous monitoring and integration of sensory signals to infer our body's motion and orientation within the environment. However, when sensory information is no longer contextually relevant to balancing the body (e.g., when sensory and motor signals are incongruent), sensory- evoked balance responses are rapidly suppressed, much earlier than any conscious perception of changes in balance control. Here, we used a robotic balance simulator to assess whethe...
-
作者：Long, Min; Jimeno-Pozo, Alejandro; Sainz-Cruz, Hector; Pantaleon, Pierre A.; Guinea, Francisco
摘要：The group of moir & eacute; graphene superconductors keeps growing, and by now it contains twisted graphene multilayers as well as untwisted stacks. We analyze here the contribution of long-range charge fluctuations in the superconductivity of twisted double bilayers and helical trilayers, and compare the results to twisted bilayer graphene. A diagrammatic approach which depends on a few, well-known parameters is used. We find that the critical temperature and the order parameter differ signif...
-
作者：Malosso, Cesare; Manko, Natalia; Izzo, Maria Grazia; Baroni, Stefano; Hassanali, Ali
作者单位：International School for Advanced Studies (SISSA); Abdus Salam International Centre for Theoretical Physics (ICTP)
摘要：Over the last decade, an increasing body of evidence has emerged, supporting the existence of a metastable liquid-liquid critical point in supercooled water whereby two distinct liquid phases of different densities coexist. Analyzing long molecular dynamics simulations performed using deep neural-network force fields trained to accurate quantum mechanical data, we demonstrate that the low-density liquid phase displays a strong propensity toward spontaneous polarization, as witnessed by large a...
-
作者：Muehlemann, Barbara; Trimpert, Jakob; Walper, Felix; Schmidt, Marie L.; Jansen, Jenny; Schroeder, Simon; Jeworowski, Lara M.; Beheim-Schwarzbach, Jorn; Bleicker, Tobias; Niemeyer, Daniela; Richter, Anja; Adler, Julia M.; Vidal, Ricardo Martin; Langner, Christine; Vladimirova, Daria; Wilks, Samuel H.; Smith, Derek J.; Voss, Mathias; Paltzow, Lea; Christophersen, Christina Martinez; Rose, Ruben; Krumbholz, Andi; Jones, Terry C.; Corman, Victor M.; Drosten, Christian
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; German Center for Infection Research; Free University of Berlin; University of Cambridge; University of Kiel; University of Kiel; Schleswig Holstein University Hospital; Labor Berlin - Charite Vivantes GmbH
摘要：Severe acute respiratory syndrome Coronavirus 2 (SARS-- CoV-2)- 2) has developed substantial antigenic variability. As the majority of the population now has pre-- existing immunity due to infection or vaccination, the use of experimentally generated animal immune sera can be valuable for measuring antigenic differences between virus variants. Here, we immunized Syrian hamsters by two successive infections with one of nine SARS-CoV-2- CoV- 2 variants. Their sera were titrated against 16 SARS-C...
-
作者：Szelenyi, Eric R.; Navarrete, Jovana S.; Murry, Alexandria D.; Zhang, Yizhe; Girven, Kasey S.; Kuo, Lauren; Cline, Marcella M.; Bernstein, Mollie X.; Burdyniuk, Mariia; Bowler, Bryce; Goodwin, Nastacia L.; Juarez, Barbara; Zweifel, Larry S.; Golden, Sam A.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University System of Maryland; University of Maryland Baltimore
摘要：High- throughput volumetric fluorescent microscopy pipelines can spatially integrate whole- brain structure and function at the foundational level of single cells. However, conventional fluorescent protein (FP) modifications used to discriminate single cells possess limited efficacy or are detrimental to cellular health. Here, we introduce a synthetic and nondeleterious nuclear localization signal (NLS) tag strategy, called Arginine-rich NLS (ArgiNLS), that optimizes genetic labeling and downs...
