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作者：Ranjan, Rajeev; Srijan, Sonali; Balekuttira, Somaiah; Agarwal, Tina; Ramey, Melissa; Dobbins, Madison; Kuhn, Rachel; Wang, Xiaojin; Hudson, Karen; Li, Ying; Varala, Kranthi
作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; United States Department of Agriculture (USDA)
摘要：Organ - specific gene expression datasets that include hundreds to thousands of experiments allow the reconstruction of organ - level gene regulatory networks (GRNs). However, creating such datasets is greatly hampered by the requirements of extensive and tedious manual curation. Here, we trained a supervised classification model that can accurately classify the organ - of - origin for a plant transcriptome. This K - Nearest Neighbor - based multiclass classifier was used to create organ - spe...
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作者：Zhang, Zhibo; Zhang, Shan; Wang, Qing; Lu, Anliang; Chen, Zhaoqi; Yang, Ziyin; Luan, Junhua; Su, Rui; Guan, Pengfei; Yang, Yong
作者单位：City University of Hong Kong; Chinese Academy of Engineering Physics; Beijing Computational Science Research Center (CSRC); Shanghai University; City University of Hong Kong; Hangzhou Dianzi University
摘要：Traditional metallic glasses (MGs), based on one or two principal elements, are notoriously known for their lack of tensile ductility at room temperature. Here, we developed a multiprincipal element MG (MPEMG), which exhibits a gigapascal yield strength, significant strain hardening that almost doubles its yield strength, and 2% uniform tensile ductility at room temperature. These remarkable properties stem from the heterogeneous amorphous structure of our MPEMG, which is composed of atoms wit...
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作者：Backholm, Matilda; Karki, Tytti; Nurmi, Heikki A.; Vuckovac, Maja; Turkki, Valtteri; Lepikko, Sakari; Jokinen, Ville; Quere, David; Timonen, Jaakko V. I.; Ras, Robin H. A.
作者单位：Aalto University; Aalto University; Aalto University; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Universite Paris Cite
摘要：Superhydrophobic surfaces are often seen as frictionless materials, on which water is highly mobile. Understanding the nature of friction for such water - repellent systems is central to further minimize resistance to motion and energy loss in applications. For slowly moving drops, contact - line friction has been generally considered dominant on slippery superhydrophobic surfaces. Here, we show that this general rule applies only at very low speed. Using a micropipette force sensor in an osci...
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作者：Koch, Alexander K.; Monster, Dan; Nafziger, Julia
作者单位：Aarhus University
摘要：We present an experiment on the immediate and lasting effects of reminder nudges in a complex environment. In the study, 1,542 subjects face a setting where, within a brief time frame, they have to pay attention to and perform multiple actions in a computer game. The experiment investigates i) the effect of reminders on the reminded actions and their spillovers on nonreminded actions; ii) spillovers between multiple nudges when the number of reminded actions is increased; and iii) intertempora...
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作者：Lee, Yuan; Dai, Wenhan; Towsley, Don; Englund, Dirk
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Massachusetts System; University of Massachusetts Amherst; Massachusetts Institute of Technology (MIT)
摘要：The central aim of quantum networks is to facilitate user connectivity via quantum channels, but there is an open need for benchmarking metrics to compare diverse quantum networks. Here, we propose a general framework for quantifying the performance of a quantum network by estimating the value created by connecting users through quantum channels. In this framework, we define the quantum network utility metric U QN to capture the social and economic value of quantum networks. The proposed frame...
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作者：Muenzel, Dominic; Bani, Alessia; De Brauwer, Maarten; Stewart, Eleanor; Djakiman, Cilun; Halwi; Purnama, Ray; Yusuf, Syafyuddin; Santoso, Prakas; Hukom, Frensly D.; Struebig, Matthew; Jompa, Jamaluddin; Limmon, Gino; Dumbrell, Alex; Beger, Maria
作者单位：University of Leeds; University of Kent; University of Essex; University of Derby; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Universitas Pattimura; Universitas Hasanuddin; Universitas Hasanuddin; Bogor Agricultural University; Universitas Pattimura; University of Queensland
摘要：Environmental DNA (eDNA) metabarcoding has the potential to revolutionize conservation planning by providing spatially and taxonomically comprehensive data on biodiversity and ecosystem conditions, but its utility to inform the design of protected areas remains untested. Here, we quantify whether and how identifying conservation priority areas within coral reef ecosystems differs when biodiversity information is collected via eDNA analyses or traditional visual census records. We focus on 147 ...
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作者：Okabe, Yuta; Murakoshi, Nobuyuki; Kurebayashi, Nagomi; Inoue, Hana; Ito, Yoko; Murayama, Takashi; Miyoshi, Chika; Funato, Hiromasa; Ishii, Koichiro; Xu, Dongzhu; Tajiri, Kazuko; Qin, Rujie; Aonuma, Kazuhiro; Murakata, Yoshiko; Song, Zonghu; Wakana, Shigeharu; Yokoyama, Utako; Sakurai, Takashi; Aonuma, Kazutaka; Ieda, Masaki; Yanagisawa, Masashi
作者单位：University of Tsukuba; Juntendo University; Tokyo Medical University; University of Tsukuba; RIKEN; Keio University
摘要：Inherited arrhythmia syndromes (IASs) can cause life - threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development of devices to prevent SCDs, the precise molecular mechanisms that induce detrimental arrhythmias remain to be fully investigated, and more effective therapies are desirable. In the present study, we screened a large - scale randomly mutagenized mouse library by electrocardiography to establish a dise...
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作者：Marinelli, Fabrizio; Faraldo- Gomez, Jose D.
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
摘要：Secondary-active transporters catalyze the movement of myriad substances across all cellular membranes, typically against opposing concentration gradients, and without consuming any ATP. To do so, these proteins employ an intriguing structural mechanism evolved to be activated only upon recognition or release of the transported species. We examine this self-regulated mechanism using a homolog of the cardiac Na+/Ca2+ exchanger as a model system. Using advanced computer simulations, we map out t...
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作者：Wallace, Laura E.; Reeves, Stephanie L.; Spencer, Steven J.; Wilson, Timothy
作者单位：University of Chicago; University System of Ohio; Ohio State University; University System of Ohio; Ohio University
摘要：Many mainstream organizations celebrate their historical successes. In their history, however, they often marginalized racial minorities, women, and other underrepresented groups. We suggest that when organizations celebrate their histories, even without mentioning historical marginalization, they can undermine belonging and intentions to join the organization among historically marginalized groups. Four experiments demonstrate that Black participants who were exposed to an organization that c...
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作者：Nelder, Mark P.; Schats, Rachel; Poinar, Hendrik N.; Cooke, Amanda; Brickley, Megan B.
作者单位：Public Health Ontario; Leiden University; Leiden University - Excl LUMC; McMaster University; McMaster University; McMaster University
摘要：Malaria is a disease of global significance. Ongoing changes to the earth's climate, antimalarial resistance, insecticide resistance, and socioeconomic decline test the resilience of malaria prevention programs. Museum insect specimens present an untapped resource for studying vector-borne pathogens, spurring the question: Do historical mosquito collections contain Plasmodium DNA, and, if so, can museum specimens be used to reconstruct the historical epidemiology of malaria? In this Perspectiv...
