-
作者：Qu, Bingqian; Miskey, Csaba; Goemer, Andre; Kleinert, Robin D. V.; Ibanez, Sara Calvo; Eberle, Regina; Ebenig, Aileen; Postmus, Dylan; Nocke, Maximilian K.; Herrmann, Maike; Itotia, Tabitha K.; Herrmann, Simon T.; Heinen, Natalie; Hoeck, Sebastian; Hastert, Florian D.; von Rhein, Christine; Schuermann, Christoph; Li, Xue; van Zandbergen, Ger; Widera, Marek; Ciesek, Sandra; Schnierle, Barbara S.; Tarr, Alexander W.; Steinmann, Eike; Goffinet, Christine; Pfaender, Stephanie; Locker, Jacomina Krijnse; Muehlebach, Michael D.; Todt, Daniel; Brown, Richard J. P.
作者单位：Paul Ehrlich Institute; Paul Ehrlich Institute; Ruhr University Bochum; Paul Ehrlich Institute; Liverpool School of Tropical Medicine; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Paul Ehrlich Institute; University of Hamburg; University Medical Center Hamburg-Eppendorf; Ruprecht Karls University Heidelberg; Paul Ehrlich Institute; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Goethe University Frankfurt; Goethe University Frankfurt Hospital; German Center for Infection Research; University of Nottingham; University of Nottingham; University of Nottingham; University of Lubeck; German Center for Infection Research
摘要：The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing cells, although how increased entry impacts downstream viral and host processes remains unclear. To investigate this in more detail, we performed infection assays in engineered cells promoting ACE2-mediated entry with and without TMPRSS2 coexpression. Electron microscopy and inhibitor experiments indicated TMPRSS2-mediated cell entry...
-
作者：Levy, Thomas E.; Smith, Neil G.; Najjar, Mohammad; Vaknin, Yoav; Ben-Yosef, Erez
作者单位：University of California System; University of California San Diego; Tel Aviv University
-
作者：Ji, Shaoyang; Guo, Yuqiong; Yan, Wei; Ding, Jinjian; Hong, Wenjun; Wu, Xiaoyun; Ku, Tingting; Yue, Huifeng; Sang, Nan; Murphy, Catherine
作者单位：Shanxi University; Xuzhou Medical University; China Jiliang University; China Jiliang University
摘要：As a global problem, fine particulate matter (PM 2.5 ) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, the most important question is to clarify whether and how PM 2.5 causally contributes to these mental disorders and which components are the most dangerous for crucial mitigation in a particular place. In the present study, we chronically subjected male mice to a real - world PM 2.5 exposure syste...
-
作者：Troppoli, Timothy A.; Yang, Chun; Katsuki, Fumi; Uygun, David S.; Lin, Ilyan; Aguilar, David D.; Spratt, Tristan; Basheer, Radhika; Mcnally, James M.; Chan, C. Savio; Mckenna, James T.; Brown, Ritchie E.
作者单位：Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Harvard University; Harvard Medical School; Northwestern University; Feinberg School of Medicine
摘要：Here, we describe a group of basal forebrain (BF) neurons expressing neuronal Per-Arnt-Sim (PAS) domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders. Immunohistochemical staining in Npas1- cre-2A- TdTomato mice revealed BF Npas1+ neurons are distinct from well- studied parvalbumin or cholinergic neurons. Npas1 staining in GAD67-GFP knock - in mice confirmed that the vast majority of Npas1+ neurons are GABAergic, with minimal colocalization with glutamate...
-
作者：Chen, Jiewen; Liu, Xiyuan; Zou, Yi; Gong, Junli; Ge, Zhenhuang; Lin, Xiaorong; Zhang, Wei; Huang, Hongyan; Zhao, Jianli; Saw, Phei Er; Lu, Yongjun; Hu, Hai; Song, Erwei
作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Southern Medical University - China; Sun Yat Sen University; Sun Yat Sen University; Southern Medical University - China
摘要：A high - fat diet (HFD) is a high - risk factor for the malignant progression of cancers through the disruption of the intestinal microbiota. However, the role of the HFDrelated gut microbiota in cancer development remains unclear. This study found that obesity and obesity - related gut microbiota were associated with poor prognosis and advanced clinicopathological status in female patients with breast cancer. To investigate the impact of HFDassociated gut microbiota on cancer progression, we ...
-
作者：Marshall, Wallace F.; Fung, Jennifer C.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：In many organisms, most notably Drosophila , homologous chromosomes associate in somatic cells, a phenomenon known as somatic pairing, which takes place without double strand breaks or strand invasion, thus requiring some other mechanism for homologs to recognize each other. Several studies have suggested a specific button model, in which a series of distinct regions in the genome, known as buttons, can associate with each other, mediated by different proteins that bind to these different regi...
-
作者：Lee, Junyeop; Lee, Jina; Sohn, Eric J.; Taglialatela, Angelo; O'Sullivan, Roderick J.; Ciccia, Alberto; Min, Jaewon
作者单位：Columbia University; Columbia University; Columbia University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Columbia University
摘要：Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism mediated by break - induced replication, evident in approximately 15% of human cancers. A characteristic feature of ALT cancers is the presence of C - circles, circular single - stranded telomeric DNAs composed of C - rich sequences. Despite the fact that extrachromosomal C - rich single - stranded DNAs (ssDNAs), including C - circles, are unique to ALT cells, their generation process remains undefined. Here, we int...
-
作者：Tominaga, Kento; Ozaki, Shogo; Sato, Shohei; Katayama, Tsutomu; Nishimura, Yuki; Omae, Kimiho; Iwasaki, Wataru
作者单位：University of Tokyo; Kyushu University; University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo
摘要：Several microbial genomes lack textbook - defined essential genes. If an essential gene is absent from a genome, then an evolutionarily independent gene of unknown function complements its function. Here, we identified frequent nonhomologous replacement of an essential component of DNA replication initiation, a replicative helicase loader gene, in Vibrionaceae . Our analysis of Vibrionaceae genomes revealed two genes with unknown function, named vdhL1 and vdhL2 , that were substantially enrich...
-
作者：Wang, Huidong; Song, Jing; Hunt, Benjamin J.; Zuo, Kairan; Zhou, Huiru; Hayward, Angela; Li, Bingbing; Xiao, Yajuan; Geng, Xing; Bass, Chris; Zhou, Shutang
作者单位：Henan University; University of Exeter
摘要：Phytophagous insects have evolved sophisticated detoxification systems to overcome the antiherbivore chemical defenses produced by many plants. However, how these biotransformation systems differ in generalist and specialist insect species and their role in determining insect host plant range remains an open question. Here, we show that UDP - glucosyltransferases (UGTs) play a key role in determining the host range of insect species within the Spodoptera genus. Comparative genomic analyses of ...
-
作者：Li, Yanning; Jenn, Alan
作者单位：University of California System; University of California Davis
摘要：California, a pioneer in EV adoption, has enacted ambitious electric vehicle (EV) policies that will generate a large burden on the state's electric distribution system. We investigate the statewide impact of uncontrolled EV charging on the electric distribution networks at a large scale and high granularity, by employing an EV charging profile projection that combines travel demand model, EV adoption model, and real - world EV charging data. We find a substantial need for infrastructure upgra...
