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作者：Hasson, Michael; Marvin, M. Colin; Lapotre, Mathieu G. A.
作者单位：Stanford University
摘要：As sand moves across Earth's landscapes, the shapes of individual grains evolve, and microscopic textures accumulate on their surfaces. Because transport processes vary between environments, the shape and suite of microtextures etched on sand grains provide insights into their transport histories. For example, previous efforts to link micro- textures to transport environments have demonstrated that they can provide important information about the depositional environments of rocks with few oth...
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作者：Lesaffre, Thomas; Pannell, John R.; Mullon, Charles
作者单位：University of Lausanne
摘要：The many independent transitions from hermaphroditism to separate sexes (dioecy) in flowering plants and some animal clades must often have involved the emergence of a male and female heterogamety). Current estimates indicate that XY sex determination is much more frequent than ZW, but the reasons for this asymmetry are unclear. One proposition is that separate sexes evolve through the invasion of sterility mutations at closely linked loci, in which case XY sex determination evolves if the ini...
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作者：Chen, Weitao; Wu, Junqiang; Yang, Chao; Li, Suying; Liu, Zhewei; An, Yongyan; Wang, Xuejie; Cao, Jiaming; Xu, Jiahui; Duan, Yangyang; Yuan, Xue; Zhang, Xin; Zhou, Yiren; Ip, Jacque Pak Kan; Fu, Amy K. Y.; Ip, Nancy Y.; Yao, Zhongping; Liu, Kai
作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong Polytechnic University; University of Hong Kong; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Chinese University of Hong Kong; Hong Kong University of Science & Technology
摘要：Adult central nervous system (CNS) neurons down- regulate growth programs after injury, leading to persistent regeneration failure. Coordinated lipids metabolism is required to synthesize membrane components during axon regeneration. However, lipids also function as cell signaling molecules. Whether lipid signaling contributes to axon regeneration remains unclear. In this study, we showed that lipin1 orchestrates mechanistic target of rapamycin (mTOR) and STAT3 signaling pathways to determine ...
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作者：Juang, Duane S.; Wightman, Wren E.; Lozano, Gabriel L.; Juang, Terry D.; Barkal, Layla J.; Yu, Jiaquan; Garavito, Manuel F.; Hurley, Amanda; Venturelli, Ophelia S.; Handelsman, Jo; Beebe, David J.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Multispecies microbial communities drive most ecosystems on Earth. Chemical and biological interactions within these communities can affect the survival of individual members and the entire community. However, the prohibitively high number of possible interactions within a microbial community has made the characterization of factors that influence community development challenging. Here, we report a Microbial Community Interaction (mu CI) device to advance the systematic study of chemical and ...
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作者：Rowntree, Louise C.; Audsley, Jennifer; Allen, Lilith F.; Mcquilten, HayleyA.; Hagen, Ruth R.; Chaurasia, Priyanka; Petersen, Jan; Littler, Dene R.; Tan, Hyon-Xhi; Murdiyarso, Lydia; Habel, Jennifer R.; Foo, IsabelleJ. H.; Zhang, Wuji; ten Berge, Elizabeth R. V.; Ganesh, Hanujah; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cheng, Samuel M. S.; Kwok, Janette S. Y.; Jayasinghe, Dhilshan; Gras, Stephanie; Juno, Jennifer A.; Wheatley, Adam K.; Kent, StephenJ.; Rossjohn, Jamie; Cheng, Allen C.; Kotsimbos, Tom C.; Trubiano, Jason A.; Holmes, Natasha E.; Chan, Ken Ka Pang; Hui, David S. C.; Peiris, Malik; Poon, Leo L. M.; Lewin, Sharon R.; Doherty, Peter C.; Thevarajan, Irani; Valkenburg, Sophie A.; Kedzierska, Katherine; Nguyen, Thi H. O.
作者单位：University of Melbourne; Peter Doherty Institute; University of Melbourne; Peter Doherty Institute; Monash University; Monash University; University of Hong Kong; University of Hong Kong; La Trobe University; La Trobe University; Cardiff University; Monash University; Monash University; Monash Health; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; University of Melbourne; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; University of Melbourne; University of Melbourne; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Melbourne Health; Royal Melbourne Hospital; University of Melbourne; Peter Doherty Institute; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates
摘要：Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS- CoV-2- specific T cell responses are of key importance for viral clearance and COVID-19 recovery. However, in long COVID, the establishment and persistence of SARS- CoV-2- specific T cells are far from clear, especially beyond 12 mo postinfection and postvacci...
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作者：Zhang, Hao; Wang, Xin; Qu, Meng; Yu, Haiyan; Yin, Jianping; Liu, Xiaochuan; Liu, Yuhong; Zhang, Bo; Zhang, Yanhong; Wei, Zhangliang; Yang, Fangfang; Wang, Jingtian; Shi, Chengcheng; Fan, Guangyi; Sun, Jun; Long, Lijuan; Hutchins, David A.; Bowler, Chris; Lin, Senjie; Wang, Dazhi; Lin, Qiang
作者单位：Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Xiamen University; Beijing Genomics Institute (BGI); China University of Geosciences; University of Southern California; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); University of Connecticut; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Algae mostly occur either as unicellular (microalgae) or multicellular (macroalgae) species, both being uninucleate. There are important exceptions, however, as some unicellular algae are multinucleate and macroscopic, some of which inhabit tropical seas and contribute to biocalcification and coral reef robustness. The evolutionary mechanisms and ecological significance of multinucleation and associated traits (e.g., rapid wound healing) are poorly understood. Here, we report the genome of Hal...
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作者：Reaser, Jamie K.; Kolby, Jonathan E.
作者单位：Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute
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作者：Tanaka, Daisuke; Maruyama, Fumito
作者单位：University of Toyama; Hiroshima University
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作者：Hayakawa-Yano, Yoshika; Furukawa, Takako; Matsuo, Tsuyoshi; Ogasawara, Takahisa; Nogami, Masahiro; Yokoyama, Kazumasa; Yugami, Masato; Shinozaki, Munehisa; Nakamoto, Chihiro; Sakimura, Kenji; Koyama, Akihide; Ogi, Kazuhiro; Onodera, Osamu; Takebayashi, Hirohide; Okano, Hideyuki; Yano, Masato
作者单位：Niigata University; Keio University; Keio University; Takeda Pharmaceutical Company Ltd; Niigata University; Niigata University; Niigata University
摘要：Many RNA- binding proteins (RBPs) are linked to the dysregulation of RNA metabolism in motor neuron diseases (MNDs). However, the molecular mechanisms underlying MN vulnerability have yet to be elucidated. Here, we found that such an RBP, Quaking5 (Qki5), contributes to formation of the MN- specific transcriptome profile, termed MN- ness, through the posttranscriptional network and maintenance of the mature MNs. Immunohistochemical analysis and single- cell RNA sequencing (scRNA- seq) revealed...
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作者：Taira, Masanori; Ozato, Keiko; Harland, Richard M.; Moody, Sally A.; Saint-Jeannet, Jean-Pierre
作者单位：Chuo University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); University of California System; University of California Berkeley; George Washington University; New York University
