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作者：Carricaburu, Etta; Benner, Orion; Burlingham, Scott R.; Passos, Carolina Dos Santos; Hobaugh, Natalia; Karr, Charles H.; Chanda, Soham
作者单位：Colorado State University System; Colorado State University Fort Collins; University of Chicago; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
摘要：Synapses containing gamma-aminobutyric acid (GABA) constitute the primary centers for inhibitory neurotransmission in our nervous system. It is unclear how these synaptic structures form and align their postsynaptic machineries with presynaptic terminals. Here, we monitored the cellular distribution of several GABAergic postsynaptic proteins in a purely glutamatergic neuronal culture derived from human stem cells, which virtually lacks any vesicular GABA release. We found that several GABAA re...
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作者：Ghasemian, Amir; Christakis, Nicholas A.
作者单位：Yale University
摘要：Negative or antagonistic relationships are common in human social networks, but they are less often studied than positive or friendly relationships. The existence of a capacity to have and to track antagonistic ties raises the possibility that they may serve a useful function in human groups. Here, we analyze empirical data gathered from 24,770 and 22,513 individuals in 176 rural villages in Honduras in two survey waves 2.5 y apart in order to evaluate the possible relevance of antagonistic re...
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作者：Jouault, Corentin; Condamine, Fabien L.; Legendre, Frederic; Perrichot, Vincent
作者单位：Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU)
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作者：Ceolini, Enea; Ridderinkhof, K. Richard; Ghosh, Arko; Carpenter, Stephen
作者单位：Leiden University; Leiden University - Excl LUMC; University of Amsterdam
摘要：We experience a life that is full of ups and downs. The ability to bounce back after adverse life events such as the loss of a loved one or serious illness declines with age, and such isolated events can even trigger accelerated aging. How humans respond to common day-to-day perturbations is less clear. Here, we infer the aging status from smartphone behavior by using a decision tree regression model trained to accurately estimate the chronological age based on the dynamics of touchscreen inte...
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作者：Herrera, Alfa; Packer, Megan M.; Lemus, Monica Rosas-; Minasov, George; Chen, Jiexi; Brumell, John H.; Satchell, Karla J. F.
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of New Mexico
摘要：Vibrio vulnificus causes life- threatening wound and gastrointestinal infections, mediated primarily by the production of a Multifunctional- Autoprocessing Repeats - In - Toxin (MARTX) toxin. The most commonly present MARTX effector domain, the Makes Caterpillars Floppy - like (MCF) toxin, is a cysteine protease stimulated by host adenosine diphosphate (ADP) ribosylation factors (ARFs) to autoprocess. Here, we show processed MCF then binds and cleaves host Ras- related proteins in brain (Rab) ...
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作者：Rhana, Paula; Matsumoto, Collin; Fong, Zhihui; Costa, Alexandre D.; Del Villar, Silvia G.; Dixon, Rose E.; Santana, L. Fernando
作者单位：University of California System; University of California Davis
摘要：The heart beats approximately 100,000 times per day in humans, imposing substantial energetic demands on cardiac muscle. Adenosine triphosphate (ATP) is an essential energy source for normal function of cardiac muscle during each beat, as it powers ion transport, intracellular Ca2+ handling, and actin-myosin cross-bridge cycling. Despite this, the impact of excitation-contraction coupling on the intracellular ATP concentration ([ATP](i)) in myocytes is poorly understood. Here, we conducted rea...
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作者：Park, Jiho; Lee, Jongeun; Hur, Yunjung; Kim, Chan- Johng; Kim, Han Bit; Um, Dahun; Kim, Da Som; Lee, June - Yong; Park, Sungjun; Park, Youngjae; Kim, Tae- Kyung; Im, Sin- Hyeog; Kim, Sung Won; Kwok, Seung- Ki; Lee, Yoontae
作者单位：Pohang University of Science & Technology (POSTECH); Catholic University of Korea; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Korea Research Institute of Chemical Technology (KRICT); Catholic University of Korea; Seoul St. Mary's Hospital; Yonsei University; Catholic University of Korea; Seoul St. Mary's Hospital
摘要：Follicular helper T (T FH ) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE). ETV5, a member of the ETS transcription factor family, promotes T FH cell differentiation in mice. In this study, we examined the role of ETV5 in the pathogenesis of lupus in mice and humans. T cell-specific deletion of Et...
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作者：Venkatraman, Jayameenakshi; Cortinas, Rodrigo G.; Frattini, Nicholas E.; Xiao, Xu; Devoret, Michel H.
作者单位：Yale University; Yale University; University of California System; University of California Santa Barbara
摘要：We present the experimental finding of multiple simultaneous two -fold degeneracies in the spectrum of a Kerr oscillator subjected to a squeezing drive. This squeezing drive resulting from a three -wave mixing process, in combination with the Kerr interaction, creates an effective static two -well potential in the phase space rotating at half the frequency of the sinusoidal drive generating the squeezing. Remarkably, these degeneracies can be turned on -and -off on demand, as well as their num...
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作者：Li, Tianjie; Shahabi, Shandy; Biswas, Tapan; V. Tsodikov, Oleg; Pan, Wenfei; Huang, De-Bin; Wang, Vivien Ya-Fan; Wang, Yi; Ghosh, Gourisankar
作者单位：Chinese University of Hong Kong; University of California System; University of California San Diego; University of Kentucky; University of Macau
摘要：The dimeric nuclear factor kappa B (NF - - K B) transcription factors (TFs) regulate gene expression by binding to a variety of -K B DNA elements with conserved G:C - rich flanking sequences enclosing a degenerate central region. Toward defining mechanistic principles of affinity regulated by degeneracy, we observed an unusual dependence of the affinity of RelA on the identity of the central base pair, which appears to be noncontacted in the complex crystal structures. The affinity of -K B sit...
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作者：Mansat, Melanie; Kpotor, Afi Oportune; Chicanne, Gaetan; Picot, Melanie; Mazars, Anne; Flores- Flores, Remy; Payrastre, Bernard; Hnia, Karim; Viaud, Julien
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; CHU de Toulouse
摘要：Myogenesis is a multistep process that requires a spatiotemporal regulation of cell events resulting finally in myoblast fusion into multinucleated myotubes. Most major insights into the mechanisms underlying fusion seem to be conserved from insects to mammals and include the formation of podosome - like protrusions (PLPs) that exert a driving force toward the founder cell. However, the machinery that governs this process remains poorly understood. In this study, we demonstrate that MTM1 is th...
