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作者：Hu, Chia - Wei; Wang, Ao; Fan, Dacheng; Worth, Matthew; Chen, Zhengwei; Huang, Junfeng; Xie, Jinshan; Macdonald, John; Li, Lingjun; Jiang, Jiaoyang
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：O - GlcNAcase (OGA) is the only human enzyme that catalyzes the hydrolysis (deglycosylation) of O - linked beta - N - acetylglucosaminylation (O - GlcNAcylation) from numerous protein substrates. OGA has broad implications in many challenging diseases including cancer. However, its role in cell malignancy remains mostly unclear. Here, we report that a cancerderived point mutation on the OGA's noncatalytic stalk domain aberrantly modulates OGA interactome and substrate deglycosylation toward a ...
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作者：Li, Ning; Flanagan, Ben A.; Edmands, Suzanne; Feldman, Marcus
作者单位：University of Southern California
摘要：Mitochondria perform an array of functions, many of which involve interactions with gene products encoded by the nucleus. These mitochondrial functions, particularly those involving energy production, can be expected to differ between sexes and across ages. Here, we measured mitochondrial effects on sex- and age- specific gene expression in parental and reciprocal F1 hybrids between allopatric populations of Tigriopus californicus with over 20% mitochondrial DNA divergence. Because the species...
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作者：Lundberg, Ian; Brown-Weinstock, Rachel; Clampet-Lundquist, Susan; Pachman, Sarah; Nelson, Timothy J.; Yang, Vicki; Edin, Kathryn; Salganik, Matthew J.
作者单位：Cornell University; Princeton University; Saint Joseph's University; Princeton University; Princeton University
摘要：Why are some life outcomes difficult to predict? We investigated this question through in-depth qualitative interviews with 40 families sampled from a multidecade longitudinal study. Our sampling and interviewing process was informed by the earlier efforts of hundreds of researchers to predict life outcomes for participants in this study. The qualitative evidence we uncovered in these interviews combined with a mathematical decomposition of prediction error led us to create a conceptual framew...
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作者：Meynard-Piganeau, Barthelemy; Feinauer, Christoph; Weigt, Martin; Walczak, Aleksandra M.; Mora, Thierry
作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Bocconi University; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite
摘要：The accurate prediction of binding between T cell receptors (TCR) and their cognate epitopes is key to understanding the adaptive immune response and developing immunotherapies. Current methods face two significant limitations: the shortage of comprehensive high-quality data and the bias introduced by the selection of the negative training data commonly used in the supervised learning approaches. We propose a method, Transformer -based Unsupervised Language model for Interacting Peptides and T...
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作者：Porte, Remi; Belloy, Marcy; Audibert, Alexis; Bassot, Emilie; Aida, Amel; Alis, Marine; Miranda-Capet, Romain; Jourdes, Aurelie; van Gisbergen, Klaas P. J. M.; Masson, Frederick; Blanchard, Nicolas
作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Fundacao Champalimaud
摘要：Chronic Toxoplasma gondii infection induces brain - resident CD8+ T cells (bTr), but the protective functions and differentiation cues of these cells remain undefined. Here, we used a mouse model of latent infection by T. gondii leading to effective CD8+ T cell- mediated parasite control. Thanks to antibody depletion approaches, we found that peripheral circulating CD8+ T cells are dispensable for brain parasite control during chronic stage, indicating that CD8+ bTr are able to prevent brain p...
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作者：Postek, Witold; Staskiewicz, Klaudia; Lilja, Elin; Waclaw, Bartlomiej
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作者：Buntaine, Mark T.; Komakech, Polycarp; Shen, Shiran Victoria
作者单位：University of California System; University of California Santa Barbara; Stanford University
摘要：Improving urban air quality is a pressing challenge in the Global South. A key source of air pollution is the informal burning of household waste. Reducing informal burning requires governments to develop formal systems for waste disposal and for residents to adopt new disposal behaviors. Using a randomized experiment, we show that social competitions between pairs of neighborhoods in Nansana municipality, Uganda, galvanized leadership and inspired collective action to reduce informal burning....
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作者：Joseph, Julien; Prentout, Djivan; Laverre, Alexandre; Tricou, Theo; Duret, Laurent
作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Columbia University; University of Lausanne; Swiss Institute of Bioinformatics
摘要：In many mammals, recombination events are concentrated in hotspots directed by a sequence-specific DNA-binding protein named PRDM9. Intriguingly, PRDM9 has been lost several times in vertebrates, and notably among mammals, it has been pseudogenized in the ancestor of canids. In the absence of PRDM9, recombination hotspots tend to occur in promoter-like features such as CpG islands. It has thus been proposed that one role of PRDM9 could be to direct recombination away from PRDM9-independent hot...
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作者：Bellon, Ualisson Donardelli; Williams, Wyn; Trindade, Ricardo Ivan Ferreira; Maldanis, Lara; Galante, Douglas
作者单位：Universidade de Sao Paulo; University of Edinburgh; Vrije Universiteit Amsterdam; Universidade de Sao Paulo
摘要：Magnetotactic bacteria produce chains of nanoscopic iron minerals used for navigation, which can be preserved over geological timescales in the form of magnetofossils. controlled mineralization have been found in the geological record and termed giant magnetofossils. The biological origin and function of giant magnetofossils remains unclear, due to the lack of modern analogues to giant magnetofossils. Using distinctive Ptychographic nanotomography data of Precambrian (1.88 Ga) rocks, we recove...
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作者：Cai, Weidong; Young, Christina B.; Yuan, Rui; Lee, Byeongwook; Ryman, Sephira; Kim, Jeehyun; Yang, Laurice; Levine, Taylor F.; Henderson, Victor W.; Poston, Kathleen L.; Menon, Vinod
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Speech impediments are a prominent yet understudied symptom of Parkinson's disease (PD). While the subthalamic nucleus (STN) is an established clinical target for treating motor symptoms, these interventions can lead to further worsening of speech. The interplay between dopaminergic medication, STN circuitry, and their downstream effects on speech in PD is not yet fully understood. Here, we investigate the effect of dopaminergic medication on STN circuitry and probe its association with speech...
