2024

最新文章

• Lipid scrambling is a general feature of protein insertases AI翻译
  作者：Li, Dazhi; Rocha-Roa, Cristian; Schilling, Matthew A.; Reinisch, Karin M.; Vanni, Stefano
  作者单位：Yale University; University of Fribourg; University of Fribourg
  摘要：Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER and membranes derived from it to grow. Lipid equilibration is facilitated by integral membrane proteins called scramblases. These proteins feature a hydrophilic groove allowing the polar heads of lipids to traverse the hydrophobic membrane interior, similar to a credit card moving through a reader. Nevertheless, des...
• Unveil the origin of voltage oscillation for sodium- ion batteries operating at-40 °C AI翻译
  作者：Que, Lanfang; Yu, Fuda; Wu, Jihuai; Lan, Zhang; Feng, Yutong; Zhao, Ruizheng; Sun, Zhihao; Yang, Zhuo; Luo, Hao; Chao, Dongliang
  作者单位：Huaqiao University; Fudan University; Xiamen University of Technology
  摘要：Voltage oscillation at subzero in sodium - ion batteries (SIBs) has been a common but overlooked scenario, almost yet to be understood. For example, the phenomenon seriously deteriorates the performance of Na3V2(PO4)3 (NVP) cathode in PC (propylene carbonate)/EC (ethylene carbonate) - based electrolyte at -20 degrees C. Here, the correlation between voltage oscillation, structural evolution, and electrolytes has been revealed based on theoretical calculations, in- /ex - situ techniques, and cr...
• Widespread, bipartisan aversion exists to neighbors owning AR-15s or storing guns insecurely AI翻译
  作者：Sola, Justin L.; Pickett, Justin T.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; State University of New York (SUNY) System; University at Albany, SUNY
  摘要：Over 45,000 gun deaths occur annually in the United States, a country with more than 100 million gun owners and more than 350 million guns. Nevertheless, passing legislation to reduce gun violence is difficult because the issue is intensely polarized. Polls asking about general gun policies (e.g., AR - 15 restrictions) demonstrate that, at least in the abstract, Americans disagree vehemently about whether civilians should be able to keep and bear arms. It is possible, however, that a hidden co...
• A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues AI翻译
  作者：Szodorai, Edit; Hevesi, Zsofia; Wagner, Ludwig; Hoekfelt, Tomas G. M.; Harkany, Tibor; Schnell, Robert
  作者单位：Karolinska Institutet; Medical University of Vienna; Medical University of Vienna
  摘要：Vesicular release of neurotransmitters and hormones relies on the dynamic assembly of the exocytosis/trans-SNARE complex through sequential interactions of synaptobrevins, syntaxins, and SNAP-25. Despite SNARE- mediated release being fundamental for intercellular communication in all excitable tissues, the role of auxiliary proteins modulating the import of reserve vesicles to the active zone, and thus, scaling repetitive exocytosis remains less explored. Secretagogin is a Ca2+- sensor protein...
• Species- level, digitized wildlife trade data are essential for achieving biodiversity targets AI翻译
  作者：Tlusty, Michael F.; Cassey, Phillip; Rhyne, Andrew L.; Omrow, Delon A.; Stoett, Peter
  作者单位：University of Massachusetts System; University of Massachusetts Boston; University of Adelaide; Roger Williams University; Ontario Tech University
• Top-down modulation in canonical cortical circuits with short-term plasticity AI翻译
  作者：Waitzmann, Felix; Wu, Yue Kris; Gjorgjieva, Julijana
  作者单位：Technical University of Munich; Max Planck Society
  摘要：Cortical dynamics and computations are strongly influenced by diverse GABAergic interneurons, including those expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP). Together with excitatory (E) neurons, they form a canonical microcircuit and exhibit counterintuitive nonlinear phenomena. One instance of such phenomena is response reversal, whereby SST neurons show opposite responses to top-down modulation via VIP depending on the presence of bottom-up sensory ...
• Chemically active wetting AI翻译
  作者：Liese, Susanne; Zhao, Xueping; Weber, Christoph A.; Juelicher, Frank
  作者单位：University of Augsburg; University of Augsburg; University of Nottingham Ningbo China; Max Planck Society; Technische Universitat Dresden
  摘要：Wetting of liquid droplets on passive surfaces is ubiquitous in our daily lives, and the governing physical laws are well understood. When surfaces become active, however, the governing laws of wetting remain elusive. Here, we propose chemically active wetting as a class of active systems where the surface is active due to a binding process that is maintained away from equilibrium. We derive the corresponding nonequilibrium thermodynamic theory and show that active binding fundamentally change...
• Spatial spillovers of violent conflict amplify the impacts of climate variability on malaria risk in sub-Saharan Africa AI翻译
  作者：Yu, Qiwei; Qu, Ying; Zhang, Liqiang; Yao, Xin; Yang, Jing; Chen, Siyuan; Liu, Hui; Wang, Qihao; Wu, Mengfan; Tao, Junpei; Zhou, Chenghu; Alage, Isiaka Lukman; Liu, Suhong
  作者单位：Beijing Normal University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：Africa carries a disproportionately high share of the global malaria burden, accounting for 94% of malaria cases and deaths worldwide in 2019. It is also a politically unstable region and the most vulnerable continent to climate change in recent decades. Knowledge about the modifying impacts of violent conflict on climate-malaria relationships remains limited. Here, we quantify the associations between violent conflict, climate variability, and malaria risk in sub-Saharan Africa using health s...
• A Late Pleistocene coastal ecosystem in French Guiana was hyperdiverse relative to today AI翻译
  作者：Antoine, Pierre Olivier; Wieringa, Linde N.; Adnet, Sylvain; Aguilera, Orangel; Bodin, Stephanie C.; Cairns, Stephen; Conejeros-Vargase, Carlos A.; Cornee, Jean-Jacques; Ezerinskis, Zilvinas; Fietzke, Jan; Gribenski, Natacha O.; Grouard, Sandrine; Hendy, Austin; Hoorn, Carina; Joannes-Boyau, Renaud; Langer, Martin R.; Luque, Javier; Marivaux, Laurent; Moissette, Pierre; Nooren, Kees; Quillevere, Frederic; Sapolaite, Justina; Sciumbata, Matteo; Valla, Pierre G.; Witteveen, Nina H.; Casanova, Alexandre; Clavier, Simon; Bidgrain, Philibert; Gallay, Marjorie; Rhone, Mathieu; Heuret, Arnauld
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Universidade Federal Fluminense; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Smithsonian Institution; Smithsonian National Museum of Natural History; Universidad Nacional Autonoma de Mexico; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Montpellier; Center for Physical Sciences & Technology - Lithuania; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; University of Bern; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); University of Amsterdam; Southern Cross University; University of Johannesburg; University of Bonn; University of Cambridge; National & Kapodistrian University of Athens; Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Vrije Universiteit Amsterdam; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Universite Savoie Mont Blanc; CIRAD
  摘要：Warmer temperatures and higher sea level than today characterized the Last Interglacial interval [Pleistocene, 128 to 116 thousand years ago (ka)]. This period is a remarkable deep-time analog for temperature and sea-level conditions as projected for 2100 AD, yet there has been no evidence of fossil assemblages in the equatorial Atlantic. Here, we report foraminifer, metazoan (mollusks, bony fish, bryozoans, decapods, and sharks among others), and plant communities of coastal tropical marine a...
• Autophagy maintains endosperm quality during seed storage to preserve germination ability in Arabidopsis AI翻译
  作者：Shinozaki, Daiki; Takayama, Erina; Kawakami, Naoto; Yoshimoto, Kohki
  作者单位：Meiji University; Meiji University
  摘要：To preserve germination ability, plant seeds must be protected from environmental stresses during the storage period. Here, we demonstrate that autophagy, an intracellular degradation system, maintains seed germination ability in Arabidopsis thaliana. The germination ability of long - term (>5 years) stored dry seeds of autophagy- defective (atg) mutant and wild - type (WT) plants was compared. Long - term stored (old) seeds of atg mutants showed lower germination ability than WT seeds, althou...