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作者：Kumar, Sujeet; Davis, Rebecca M.; Ruiz, Natividad
作者单位：University System of Ohio; Ohio State University
摘要：The outer membrane (OM) of didermic gram - negative bacteria is essential for growth, maintenance of cellular integrity, and innate resistance to many antimicrobials. Its asymmetric lipid distribution, with phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet, is required for these functions. Lpt proteins form a transenvelope bridge that transports newly synthesized LPS from the inner membrane (IM) to OM, but how the bulk of phospholipids are transported betwee...
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作者：Sharika, K. M.; Thaikkandi, Swarag; Nivedita; Platt, Michael L.
作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; University of Oxford; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Groups often outperform individuals in problem -solving. Nevertheless, failure to critically evaluate ideas risks suboptimal outcomes through so-called groupthink. Prior studies have shown that people who hold shared goals, perspectives, or understanding of the environment show similar patterns of brain activity, which itself can be enhanced by consensus -building discussions. Whether shared arousal alone can predict collective decision -making outcomes, however, remains unknown. To address th...
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作者：Xu, Yao; Jabbur, Maria Luisa; Mori, Tetsuya; Young, Jamey D.; Johnson, Carl Hirschie
作者单位：Vanderbilt University; Vanderbilt University
摘要：Cyanobacteria are photosynthetic bacteria whose gene expression patterns are globally regulated by their circadian (daily) clocks. Due to their ability to use sunlight as their energy source, they are also attractive hosts for green production of pharmaceuticals, renewable fuels, and chemicals. However, despite the application of traditional genetic tools such as the identification of strong promoters to enhance the expression of heterologous genes, cyanobacteria have lagged behind other micro...
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作者：Dutt, Previn; Haider, Nasir; Mouaaz, Samar; Podmore, Lauren; Stambolic, Vuk
作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
摘要：beta- catenin has influential roles affecting embryonic development, tissue homeostasis, and human diseases including cancer. Cellular beta- catenin levels are exquisitely controlled by a variety of regulatory mechanisms. In the course of exploring the functions of the Nek10 tyrosine kinase, we observed that deletion of Nek10 in lung adenocarcinoma cells resulted in dramatic stabilization of beta- catenin, suggestive of a Nek10 role in the control of beta- catenin turnover. Nek10 - deficient c...
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作者：Kellermann, K. I.
作者单位：National Radio Astronomy Observatory (NRAO)
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作者：Wang, Nan; Waghray, Deepa; Caveney, Nathanael A.; Jude, Kevin M.; Garcia, K. Christopher
作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University
摘要：The loading of processed peptides on to major histocompatibility complex II (MHC - II) molecules for recognition by T cells is vital to cell - mediated adaptive immunity. As part of this process, MHC - II associates with the invariant chain (Ii) during biosynthesis in the endoplasmic reticulum to prevent premature peptide loading and to serve as a scaffold for subsequent proteolytic processing into MHC - II - CLIP. Cryo-electron microscopy structures of full - length Human Leukocyte Antigen - ...
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作者：Nan, Yabing; Wu, Xiaowei; Luo, Qingyu; Chang, Wan; Zhao, Pengfei; Zhang, Lingqiang; Liu, Zhihua
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
摘要：Ovarian cancer is an aggressive gynecological tumor characterized by a high relapse rate and chemoresistance. Ovarian cancer exhibits the cancer hallmark of elevated glycolysis, yet effective strategies targeting cancer cell metabolic reprogramming to overcome therapeutic resistance in ovarian cancer remain elusive. Here, we revealed that epigenetic silencing of Otubain 2 ( OTUB2 ) is a driving force for mitochondrial metabolic reprogramming in ovarian cancer, which promotes tumorigenesis and ...
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作者：Quintero, Ignacio
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS)
摘要：Rates of evolution are fundamental to understand the processes that shaped the history of life. The predominant view holds that high rates of phenotypic evolution result from lineage transitions across peaks in an adaptive landscape, with subsequent slowdowns, but evidence remains debated. I developed a phylogenetic diffused Brownian motion model that characterizes nuanced variations in evolutionary rates and use it to comprehensively assess body size evolution and its underlying rates for 2,9...
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作者：Gao, Cheng Frank; Vaikuntanathan, Suriyanarayanan; Riesenfeld, Samantha J.
作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago
摘要：RNA velocity estimation is a potentially powerful tool to reveal the directionality of transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, absent advanced metabolic labeling techniques. We developed an approach, TopicVelo, that disentangles simultaneous, yet distinct, dynamics by using a probabilistic topic model, a highly interpretable form of latent space factorization, to infer cells and genes associated with individual processes, thereby capturing cellular pl...
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作者：Gillet, Jean; Geerts, Yves; Rongy, Laurence; De Decker, Yannick
作者单位：Universite Libre de Bruxelles; Universite Libre de Bruxelles; Universite Libre de Bruxelles
摘要：A fundamental question associated with chirality is how mixtures containing equal amounts of interconverting enantiomers can spontaneously convert to systems enriched in only one of them. Enantiomers typically have similar chemical properties, but can exhibit distinct reactivity under specific conditions, and these differences can be used to bias the system's composition in favor of one enantiomer. Transport properties are also expected to differ for enantiomers in chiral solvents, but the rol...
