-
作者：Yuan, Shufang; Chiang, Hong-Wei; Liu, Guangxin; Bijaksana, Satria; He, Shaoneng; Jiang, Xiuyang; Imran, Andi M.; Wicaksono, Satrio A.; Wang, Xianfeng
作者单位：Nanyang Technological University; Nanyang Technological University; National Taiwan University; Yunnan University; Institute Technology of Bandung; Fujian Normal University; Universitas Hasanuddin; Brown University
-
作者：Goncalves, Fernando; Farooq, Harith; Harfoot, Mike; Pires, Mathias M.; Villar, Nacho; Sales, Lilian; Carvalho, Carolina; Bello, Carolina; Emer, Carine; Bovendorp, Ricardo S.; Mendes, Calebe; Beca, Gabrielle; Lautenschlager, Lais; Souza, Yuri; Pedrosa, Felipe; Paz, Claudia; Zipparro, Valesca B.; Akkawi, Paula; Berce, William; Farah, Fabiano; Freitas, Andre V. L.; Silveira, Luis Fabio; Olmos, Fabio; Geldmann, Jonas; Dalsgaard, Bo; Galetti, Mauro
作者单位：Universidade Estadual Paulista; University of Copenhagen; University of Copenhagen; University of Gothenburg; Universidade Estadual de Campinas; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); University of British Columbia; University of British Columbia Okanagan; Swiss Federal Institutes of Technology Domain; ETH Zurich; Jardim Botanico do Rio de Janeiro; Universidade Estadual de Santa Cruz; Nanyang Technological University; Australian Wildlife Conservancy; University of Miami; Universidade Estadual de Campinas; Universidade de Sao Paulo; State University System of Florida; Florida International University
摘要：An often - overlooked question of the biodiversity crisis is how natural hazards contribute to species extinction risk. To address this issue, we explored how four natural hazards, earthquakes, hurricanes, tsunamis, and volcanoes, overlapped with the distribution ranges of amphibians, birds, mammals, and reptiles that have either narrow distributions or populations with few mature individuals. To assess which species are at risk from these natural hazards, we combined the frequency and magnitu...
-
作者：Lee, Kangduk; Kim, Yoonji; Lee, Sung - Jin; Qiang, Yuan; Lee, Dongmin; Lee, Hyun Woo; Kim, Hyun; Je, H. Shawn; Sudhof, Thomas C.; Ko, Jaewon
-
作者：Shi, Lei; Derouiche, Abderahmane; Pandit, Santosh; Alazmi, Meshari; Ventroux, Magali; Kohler, Julie Bonne; Noirot-Gros, Marie-Francoise; Gao, Xin; Mijakovic, Ivan
作者单位：Chalmers University of Technology; King Abdullah University of Science & Technology; University Ha'il; King Abdullah University of Science & Technology; Universite Paris Saclay; INRAE; AgroParisTech; Technical University of Denmark
摘要：In bacteria, attenuation of protein - tyrosine phosphorylation occurs during oxidative stress. The main described mechanism behind this effect is the H 2 O 2 - triggered conversion of bacterial phosphotyrosines to protein - bound 3,4 - dihydroxyphenylalanine. This disrupts the bacterial tyrosine phosphorylation - based signaling network, which alters the bacterial polysaccharide biosynthesis. Herein, we report an alternative mechanism, in which oxidative stress leads to a direct inhibition of ...
-
作者：Vanderplas, Susan; Carriquiry, Alicia; Hofmann, Heike
作者单位：University of Nebraska System; University of Nebraska Lincoln; Iowa State University
摘要：When wires are cut, the tool produces striations on the cut surface; as in other forms of forensic analysis, these striation marks are used to connect the evidence to the source that created them. Here, we argue that the practice of comparing two wire cut surfaces introduces complexities not present in better-investigated forensic examination of toolmarks such as those observed on bullets, as wire comparisons inherently require multiple distinct comparisons, increasing the expected false disco...
-
作者：Gautheron, Jeremie; Elsayed, Solaf; Pistorio, Valeria; Lockhart, Sam; Zammouri, Jamila; Auclair, Martine; Koulman, Albert; Meadows, Sarah R.; Lhomme, Marie; Ponnaiah, Maharajah; Si-Bouazza, Redouane; Fabrega, Sylvie; Belkadi, Abdelaziz; Delaunay, Jean Louis; Ait-Slimane, Tounsia; Feve, Bruno; Vigouroux, Corinne; Ghaffar, Tawhida Y. Abdel; O'Rahilly, Stephen; Jeru, Isabelle
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Egyptian Knowledge Bank (EKB); Ain Shams University; University of Cambridge; Universite Paris Cite; Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar Foundation (QF); Qatar Genome Programme (QGP); Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
摘要：Alcohol dehydrogenase 1B (ADH1B) is a primate - specific enzyme which, uniquely among the ADH class 1 family, is highly expressed both in adipose tissue and liver. Its expression in adipose tissue is reduced in obesity and increased by insulin stimulation. Interference with ADH1B expression has also been reported to impair adipocyte function. To better understand the role of ADH1B in adipocytes, we used CRISPR/ Cas9 to delete ADH1B in human adipose stem cells (ASC). Cells lacking ADH1B failed ...
-
作者：Rakebrandt, Nikolas; Yassini, Nima; Kolz, Anna; Schorer, Michelle; Lambert, Katharina; Goljat, Eva; Brull, Anna Estrada; Rauld, Celine; Balazs, Zsolt; Krauthammer, Michael; Carballido, Jose M.; Peters, Anneli; Joller, Nicole
作者单位：University of Zurich; University of Zurich; University of Munich; Novartis; University of Munich
摘要：Through immune memory, infections have a lasting effect on the host. While memory cells enable accelerated and enhanced responses upon rechallenge with the same pathogen, their impact on susceptibility to unrelated diseases is unclear. We identify a subset of memory T helper 1 (Th1) cells termed innate acting memory T (TIA) cells that originate from a viral infection and produce IFN-gamma with innate kinetics upon heterologous challenge in vivo. Activation of memory TIA cells is induced in res...
-
作者：Choma, Ernani F.; Robinson, Lisa A.; Nadeau, Kari C.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
摘要：Electric school buses have been proposed as an alternative to reduce the health and climate impacts of the current U.S. school bus fleet, of which a substantial share are highly polluting old diesel vehicles. However, the climate and health benefits of electric school buses are not well known. As they are substantially more costly than diesel buses, assessing their benefits is needed to inform policy decisions. We assess the health benefits of electric school buses in the United States from re...
-
作者：Schott, Katharina; Usher, Samuel George; Serra, Oscar; Carnevale, Vincenzo; Pless, Stephan Alexander; Chua, Han Chow
作者单位：University of Copenhagen; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Sydney; University of Sydney
摘要：The sodium (Na + ) leak channel (NALCN) is a member of the four - domain voltage - gated cation channel family that includes the prototypical voltage - gated sodium and calcium channels (Na V s and Ca V s, respectively). Unlike Na V s and Ca V s, which have four lateral fenestrations that serve as routes for lipophilic compounds to enter the central cavity to modulate channel function, NALCN has bulky residues (W311, L588, M1145, and Y1436) that block these openings. Structural data suggest th...
-
作者：Shang, Hsien; Johnstone, Doug; Lizano, Susana
作者单位：Academia Sinica - Taiwan; National Research Council Canada; Universidad Nacional Autonoma de Mexico
