2024

最新文章

• Cultivating climate resilience in California agriculture: Adaptations to an increasingly volatile water future AI翻译
  作者：Medellin-Azuara, Josue; Escriva-Bou, Alvar; Gaudin, Amelie C. M.; Schwabe, Kurt A.; Sumner, Daniel A.
  作者单位：University of California System; University of California Merced; University of California System; University of California Los Angeles; University of California System; University of California Davis; University of California System; University of California Riverside; University of California System; University of California Davis
  摘要：California agriculture will undergo significant transformations over the next few decades in response to climate extremes, environmental regulation and policy encouraging environmental justice, and economic pressures that have long driven agricultural changes. With several local climates suited to a variety of crops, periodically abundant nearby precipitation, and public investments that facilitated abundant low- priced irrigation water, California hosts one of the most diverse and productive ...
• Targeted whole- genome recovery of single viral species in a complex environmental sample AI翻译
  作者：Chen, Liyin; Chen, Anqi; Zhang, Xinge Diana; Robles, Maria Teresa Saenz; Han, Hee- Sun; Xiao, Yi; Xiao, Gao; Pipas, James M.; Weitz, David A.
  作者单位：Harvard University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Harvard University
  摘要：Characterizing unknown viruses is essential for understanding viral ecology and preparing against viral outbreaks. Recovering complete genome sequences from environmental samples remains computationally challenging using metagenomics, especially for low- abundance species with uneven coverage. We present an experimental method for reliably recovering complete viral genomes from complex environmental samples. Individual genomes are encapsulated into droplets and amplified using multiple displac...
• A social foraging trade- off in echolocating bats reveals that they benefit from some conspecifics but are impaired when many are around AI翻译
  作者：Krivoruchko, Ksenia; Koblitz, Jens C.; Goldshtein, Aya; Biljman, Katarina; Guillen-Servent, Antonio; Yovel, Yossi
  作者单位：Tel Aviv University; Max Planck Society; Max Planck Society; Instituto de Ecologia - Mexico; Tel Aviv University; Tel Aviv University
  摘要：Social foraging is very common in the animal kingdom. Numerous studies have documented collective foraging in various species and many reported the attraction of various species to foraging conspecifics. It is nonetheless difficult to quantify the benefits and costs of collective foraging, especially in the wild. We examined the benefits and costs of social foraging using on- board microphones mounted on freely foraging Molossus nigricans bats. This allowed us to quantify the bats' attacks on ...
• APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest AI翻译
  作者：Mouery, Brandon L.; Baker, Eliyambuya M.; Mei, Liu; Wolff, Samuel C.; Mills, Christine A.; Fleifel, Dalia; Mulugeta, Nebyou; Herring, Laura E.; Cook, Jeanette Gowen
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Memorial Sloan Kettering Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting complex/cyclosome (APC/C), although the APC/C substrates whose degradation restrains G1- S progression are not fully known. The APC/C is also active in arrested cells that exited the cell cycle, but it is not clear whether APC/C maintains all types of arrest. Here, by expressing the APC/C inhibitor, EMI1, we show that ...
• Memory effects of prior subculture may impact the quality of multiomic perturbation profiles AI翻译
  作者：Bortel, Patricia; Hagn, Gerhard; Skos, Lukas; Bileck, Andrea; Paulitschke, Verena; Paulitschke, Philipp; Gleiter, Lion; Mohr, Thomas; Gerner, Christopher; Meier-Menches, Samuel M.
  作者单位：University of Vienna; University of Vienna; University of Vienna; Medical University of Vienna; Medical University of Vienna; University of Munich; Medical University of Vienna; University of Vienna
  摘要：Mass spectrometry- based omics technologies are increasingly used in perturbation studies to map drug effects to biological pathways by identifying significant molecular events. Significance is influenced by fold change and variation of each molecular parameter, but also by multiple testing corrections. While the fold change is largely determined by the biological system, the variation is determined by experimental workflows. Here, it is shown that memory effects of prior subculture can influe...
• Selective adsorption of high ionization potential value organic pollutants in wastewater AI翻译
  作者：Liang, Lihong; Cao, Jiazhen; Zhang, Yayun; Liu, Xinyue; Li, Jun; Yang, Bo; Lv, Weiyang; Yang, Qiang; Xing, Mingyang
  作者单位：East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology; Zhejiang Sci-Tech University
  摘要：It is imperative to devise effective removal strategies for high ionization potential (IP) organic pollutants in wastewater as their reduced electron-- donating capacity challenges the efficiency of advanced oxidation systems in degradation. Against this backdrop, leveraging the metal- based carbon material structure meticulously, we employed metal-- pyridine- N (M- N- C, M=Fe, Co, and Ni) as the electron transfer bridge. This distinctive design facilitated the ordered transfer of electrons fr...
• The developmental mechanics of divergent buckling patterns in the chick gut AI翻译
  作者：Gill, Hasreet K.; Yin, Sifan; Lawlor, John C.; Huycke, Tyler R.; Nerurkar, Nandan L.; Tabin, Clifford J.; Mahadevan, L.
  作者单位：Harvard University; Harvard Medical School; Harvard University; University of California System; University of California San Francisco; Columbia University; Harvard University; Harvard University
  摘要：Tissue buckling is an increasingly appreciated mode of morphogenesis in the embryo, but it is often unclear how geometric and material parameters are molecularly determined in native developmental contexts to generate diverse functional patterns. Here, we study the link between differential mechanical properties and the morphogenesis of distinct anteroposterior compartments in the intestinal tract-the esophagus, small intestine, and large intestine. These regions originate from a simple, commo...
• Structurally and mechanically tuned macroporous hydrogels for scalable mesenchymal stem cell-extracellular matrix spheroid production AI翻译
  作者：Yin, Sheng; Wu, Haipeng; Huang, Yaying; Lu, Chenjing; Cui, Jian; Li, Ying; Xue, Bin; Wu, Junhua; Jiang, Chunping; Gu, Xiaosong; Wang, Wei; Cao, Yi
  作者单位：Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Jinan Microecological Biomedicine Shandong Laboratory; Nanjing University of Information Science & Technology; Nanjing University; Nanjing University; Nanjing University; Nanjing University; Nanjing University
  摘要：Mesenchymal stem cells (MSCs) are essential in regenerative medicine. However, conventional expansion and harvesting methods often fail to maintain the essential extracellular matrix (ECM) components, which are crucial for their functionality and efficacy in therapeutic applications. Here, we introduce a bone marrow- inspired macroporous hydrogel designed for the large- scale production of MSC-ECM spheroids. Through a soft- templating approach leveraging liquid-liquid phase separation, we engi...
• Representations and generalization in artificial and brain neural networks AI翻译
  作者：Li, Qianyi; Sorscher, Ben; Sompolinsky, Haim
  作者单位：Harvard University; Harvard University; Stanford University; Hebrew University of Jerusalem
  摘要：Humans and animals excel at generalizing from limited data, a capability yet to be fully replicated in artificial intelligence. This perspective investigates generalization in biological and artificial deep neural networks (DNNs), in both in-distribution and out-of-distribution contexts. We introduce two hypotheses: First, the geometric properties of the neural manifolds associated with discrete cognitive entities, such as objects, words, and concepts, are powerful order parameters. They link ...
• Collective Hall current in chiral active fluids: Coupling of phase and mass transport through traveling bands AI翻译
  作者：Siebers, Frank; Bebon, Robin; Jayaram, Ashreya; Speck, Thomas
  作者单位：Johannes Gutenberg University of Mainz; University of Stuttgart
  摘要：Active fluids composed of constituents that are constantly driven away from thermal equilibrium can support spontaneous currents and can be engineered to have unconventional transport properties. Here, we report the emergence of (meta)stable traveling bands in computer simulations of aligning circle swimmers. These bands are different from polar flocks and, through coupling phase with mass transport, induce a bulk particle current with a component perpendicular to the propagation direction, th...