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作者：Harte, John; Brush, Micah; Umemura, Kaito; Muralikrishnan, Pranav; Newman, Erica A.
作者单位：University of California System; University of California Berkeley; The Santa Fe Institute; University of Alberta; Kobe University; University of California System; University of California Berkeley; James Madison University
摘要：In many complex systems encountered in the natural and social sciences, mechanisms governing system dynamics at a microscale depend upon the values of state variables characterizing the system at coarse- grained, macroscale (Goldenfeld and Woese, 2011, Noble et al., 2019, and Chater and Loewenstein, 2023). State variables, in turn, are averages over relevant probability distributions of the microscale variables. Neither inferential Top-Down nor mechanistic Bottom-Up modeling alone can predict ...
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作者：Li, Bohan; Zhang, Zhenguo; Tio, Raymond; Li, Jinling; Loh, Teck-Peng
作者单位：Henan University of Technology; Nanyang Technological University
摘要：Metathesis reactions that operate cleanly and reversibly under biocompatible conditions are crucial in diverse fields such as drug development, chemical biology, and dynamic combinatorial chemistry. This paper introduces an innovative strategy using the commercially available and cost- effective hydroxy(tosyloxy)iodobenzene (HTIB) as a radical initiator, enabling clean and bidirectional disulfide metathesis under biocompatible conditions. Our method facilitates efficient forward reactions by u...
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作者：Liu, Guangxue; Huang, Kaiyan; Liu, Shiyao; Xie, Yali; Huang, Jinyan; Liang, Tingbo; Zhang, Pumin
作者单位：Zhejiang University; Zhejiang University; Zhejiang University
摘要：RAD51 is related to the bacterial RecA protein and is best known for its role in homologous recombination- mediated repair of DNA damage. Here, we report an unexpected function of RAD51 in the maintenance methylation of genomic DNA, a function that is separable from its role in homologous recombination. First, it acts as an inhibitor and degradation of the DNA methyltransferase DNMT1, leading to the loss of global DNA methylation. Second, RAD51 helps UHRF1 to monoubiquitinate histone H3 H3 dim...
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作者：Krushinski, Lynn E.; Herchenbach, Patrick J.; Dick, Jeffrey E.
作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University
摘要：The curious chemistry observed in microdroplets has captivated chemists in recent years and has led to an investigation into their ability to drive seemingly impossible chemistries. One particularly interesting capability of these microdroplets is their ability to accelerate reactions by several orders of magnitude. While there have been many investigations into which reactions can be accelerated by confinement within microdroplets, no study has directly compared reaction acceleration at the l...
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作者：Chen, Xien; Koo, Jinmo; Arya, Surjeet Kumar; Palli, Subba Reddy
作者单位：University of Kentucky; Northwest A&F University - China; University of California System; University of California Riverside
摘要：Broad complex (Br- C) and eip93F (E93) transcription factors promote insect metamorphosis from larva to pupa and from pupa to adult, respectively. Recently, chronologically inappropriate morphogenesis (Chinmo) has been proposed as a larval specifier in Drosophila melanogaster. However, whether Chinmo is required for larval maintenance in lepidopteran insects, the underlying mechanisms involved in maintaining the larval stage, and its interactions with the JH signaling pathway are not well unde...
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作者：Das, Sudip; Raucci, Umberto; Neves, Rui P. P.; Ramos, Maria J.; Parrinello, Michele
作者单位：Istituto Italiano di Tecnologia - IIT; Universidade do Porto
摘要：Machine learning (ML) is transforming the investigation of complex biological processes. In enzymatic catalysis, one significant challenge is identifying the reactive conformations (RC) of the enzyme:substrate complex where the substrate assumes a precise arrangement in the active site necessary to initiate a reaction. Traditional methods are hindered by the complexity of the multidimensional free energy landscape involved in the transition from nonreactive to reactive conformations. Here, we ...
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作者：Xu, Muyuan; Hosokawa, Takayuki; Tsutsui, Ken- Ichiro; Aihara, Kazuyuki
作者单位：University of Tokyo; Tohoku University
摘要：The brain is thought to execute cognitive control by actively maintaining and flexibly updating patterns of neural activity that represent goals and rules. However, while actively maintaining patterns of activity requires robustness against noise and distractors, updating the activity requires sensitivity to task-- relevant inputs. How these conflicting demands can be reconciled in a single neural system remains unclear. Here, we study the prefrontal cortex of monkeys maintaining a covert rule...
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作者：Zheng, Minghua; Zhou, Lizhi; Huang, Yang; Zhang, Xiao; Yu, Zihao; Yang, Chengyu; Chen, Yuanzhi; Ying, Dong; Wang, Hong; Chen, Zhenqin; Liu, Chang; Tang, Zimin; Wang, Siling; Wang, Kaihang; Yang, Kaixiang; Lin, Yanqing; Li, Tingting; Zheng, Qingbing; Zheng, Zizheng; Zhang, Jun; Yu, Hai; Li, Shaowei; Gu, Ying; Xia, Ningshao
作者单位：Xiamen University; Xiamen University; Chongqing Medical University
摘要：Neutralizing antibodies (nAbs) play a crucial role in virology, antibody drug development, and vaccine research. In this study, we investigated the synergistic effect of two hepatitis E virus (HEV) nAbs, 8H3, and 8C11, which have exhibited enhanced neutralizing activity in a rhesus monkey model. We presented crystal structures of 8H3 Fab alone and a triple complex of 8C11 Fab and 8H3 Fab simultaneously binding to the HEV E2s protein (8C11:E2s:8H3). Through structural analysis, we identified cr...
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作者：Bonomi, Robin; Pietrzak, Robert H.; Cosgrove, Kelly P.
作者单位：Yale University
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作者：Smart, Zachariah Fox; Downing, Philip A.; Austin, Suzanne H.; Greeney, Harold F.; Londono, Gustavo A.; Nahid, Mominul I.; Robinson, W. Douglas; Riehl, Christina
作者单位：Princeton University; University of Oulu; Oregon State University; Yanayacu Biological Station; Universidad ICESI; Bangladesh Forest Research Institute (BFRI)
摘要：Nest predation rates critically influence avian biodiversity and evolution. In the north temperate zone, increased nest failure along edges of forest fragments is hypothesized to play a major role in the disappearance of bird species from disturbed landscapes. However, we lack comprehensive syntheses from tropical latitudes, where biodiversity is highest and increasingly threatened by habitat fragmentation and disturbance. We assembled data from five decades of field studies across the global ...
