39期

最新文章

• Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice AI翻译
  作者：de Souza Leite, Felipe; Lambert, Matthias R.; Zhang, Tracy Yuanfan; Conner, James R.; Paulo, Joao A.; Furtado Oliveira, Sheldon; Thakurta, Sanjukta Guha; Bowles, Jennifer; Gussoni, Emanuela; Gygi, Steven P.; Widrick, Jeffrey J.; Kunkel, Louis M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To clarify the underlying biology of JAG1 overexpression in dystrophic muscles, we gener...
• Severe water crisis in southern Spain under expanding irrigated agriculture: A multidimensional drought analysis AI翻译
  作者：Junquera, Victoria; Hormaza, Jose I.; Rubenstein, Daniel I.; Levin, Simon A.; Perez, Inaki Vadillo; Gavilan, Pablo Jimenez
  作者单位：University of Bern; Princeton University; Princeton University; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Malaga; CSIC-UMA - Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora (IHSM); Universidad de Malaga
  摘要：The Axarqu & iacute;a region in southern Spain, a hotspot of avocado and mango production in Europe, underwent an extreme water crisis in 2019-2024. Reservoir levels dropped below the 8% outlet threshold and groundwater in the main aquifer dropped to sea level in several locations, risking seawater intrusion. Socioeconomic impacts ranged from substantial crop losses to a potential long-term decline in regional economic viability. We examine the main drivers of this crisis using a coupled human...
• Targeting endothelial ERG to mitigate vascular regression in retinopathies AI翻译
  作者：Ma, Eric; Schafer, Christopher M.; Xie, Jun; Rudenko, Yelyzaveta; Knapp, John T. H.; Randi, Anna M.; Birdsey, Graeme M.; Griffin, Courtney T.
  作者单位：Oklahoma Medical Research Foundation; Imperial College London; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Central Oklahoma
  摘要：Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which an initial loss of retinal capillaries leads to damaging tissue ischemia followed by a compensatory neovascularization response that generates pathological capillaries in the eye. Using a mouse model of ROP and samples from DR patients, we found that the highly homologous and homeostatic erythroblast transformation-specific (ETS) family transcription factors ETS-related gene (ERG) and Friend leukemia i...
• CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma AI翻译
  作者：Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A.; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L.; Qin, Wenxin; Gao, Qiang; Bernards, Rene; Jin, Haojie
  作者单位：Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Tongji University; Fudan University; Fudan University; Sun Yat Sen University; State Key Lab Oncology South China; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency in CCA. Compound screens revealed that the VCP inhibitor CB-5339 potently suppresses CCA proliferation in a panel of patient-derived organoids by inducing cellular senescence. It is known that senescent cells persist, and this can contribute to therapy resis...
• Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance AI翻译
  作者：Fountain, Adam J.; Bohning, Jan; McLaughlin, Stephen H.; Morgan, Tomos E.; Edelstein, Paul H.; Troll, Mark; Lamers, Meindert H.; Bharat, Tanmay A. M.; Luisi, Ben F.; Ramakrishnan, Lalita
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Cambridge; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC)
  摘要：Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multidrug-resistant tuberculosis. Clinical bedaquiline resistance in Mycobacterium tuberculosis has rapidly emerged, primarily due to mutations in the transcriptional repressor Rv0678 that result in upregulation of the resistance-nodulation-division (RND) efflux pump MmpS5/ MmpL5 (MmpS5L5). Here, to understand how MmpS5L5 effluxes bedaquiline, we...
• In vitro maturation of fully active [FeFe]- hydrogenase in a defined system including the iron carrier NfuA AI翻译
  作者：Marlott, Alexander; Pagnier, Adrien; Shepard, Eric M.; Balci, Batuhan; Teye, Abraham; Warui, Douglas M.; Yang, Hao; Drena, Alex; Booker, Squire J.; Hoffman, Brian M.; Broderick, William E.; Broderick, Joan B.
  作者单位：Montana State University System; Montana State University Bozeman; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Howard Hughes Medical Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Northwestern University
  摘要：The [FeFe]- hydrogenase employs an active-site 6Fe H-cluster to catalyze the reversible reduction of protons to H2. A [4Fe-4S] subcluster of the H-cluster is synthesized by housekeeping iron-sulfur cluster assembly machinery, and then dedicated hydrogenase maturation enzymes, together with components of the glycine cleavage system, build and deliver a [2Fe] subcluster to generate the full H-cluster. Here, we report that the Escherichia coli iron-sulfur carrier protein NfuA supports in vitro ma...
• A first look at rocky exoplanets with JWST AI翻译
  作者：Kreidberg, Laura; Stevenson, Kevin B.
  作者单位：California Institute of Technology; Max Planck Society; Johns Hopkins University
  摘要：Rocky exoplanet characterization has been a top priority for early James Webb Space Telescope (JWST) science operations. Several milestones have been achieved, including the most precise rocky planet transmission spectra measured to date, and the first detection of thermal emission for rocky worlds below 800 K. Despite these advances, no atmospheres have been definitively detected. Several transmission spectra show tentative evidence for molecular absorption features, but these hints are margi...
• A spatially differentiated water pollution policy leads to economic and health inequity AI翻译
  作者：Luo, Zhonghui; Ma, Lala; Xi, Rui; Song, Ran
  作者单位：Hunan University; Kyoto University; University of Kentucky; Resources for the Future; National University of Singapore
  摘要：Disparities in air pollution exposure by socioeconomic status (SES) are well documented. However, there is much less evidence on the inequitable consequences of water pollution and policies affecting water pollution gaps. This study uncovers the distributional impact of China's 11th Five-Year Plan (2006-2010), which triggered spatially differentiated water pollution abatement for a population of almost 1.3 billion. We document that the policy reduced water pollution overall, targeting areas ba...
• The genome of the vining fern Lygodium microphyllum highlights genomic and functional differences between life phases of an invasive plant AI翻译
  作者：Pelosi, Jessie A.; Davenport, Ruth; Kuo, Li- Yaung; Gray, Levi N.; Dant, Anthony J.; Kim, Emily H.; Li, Fay - Wei; Dlugosch, Katrina M.; Krabbenhoft, Trevor J.; Barbazuk, William Bradley; Sessa, Emily B.
  作者单位：State University System of Florida; University of Florida; University of Arizona; National Tsing Hua University; State University of New York (SUNY) System; University at Buffalo, SUNY; State University System of Florida; University of Florida; Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; State University System of Florida; University of Florida; New York Botanical Garden
  摘要：Functional and genomic studies on the differences between the gametophyte and sporophyte life phases of plants remain scarce, yet unraveling these dynamics is crucial to understanding the biology of plants and the success of each phase under different conditions. Here, we provide a reference genome for the highly invasive fern Lygodium microphyllum and compare the transcriptomic and epigenomic landscapes of its gametophyte and sporophyte life phases. Under ambient conditions, we found differen...
• Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions AI翻译
  作者：Cao, Zhenqiu; Zhang, Hongjiu; Zou, Zhengting
  作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Convergent evolution, or convergence, refers to repeated, independent emergences of the same trait in two or more lineages of species during evolution, often indicating functional adaptation to specific environmental factors. Many computational methods have been proposed to investigate the genetic basis for organismal functional convergence, as an important way to decode the complex sequence-function map of proteins. These methods mostly focus on the convergence of amino acid states at the lev...