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作者：Kuromiya, Kaori; Kobayashi, Yuya; Hirano, Masato; Furuya, Shinichi
作者单位：Sony Corporation
摘要：Creativity in the arts, such as painting and musical performance, hinges on the ability to produce a wide spectrogram of perceptual experiences. In music, it has long been believed that the timbre of tones can be altered by nuanced movements of performers. Previous studies have described relationships between fundamental elements of auditory perceptions (e.g., loudness, tempo) and physical movements (e.g., force, speed), but it remains unknown whether and how delicate features of perceptual ex...
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作者：Moriyama, Miyu; Rodrigues, Gisele; Wang, Jiping; Jayewickreme, Radeesha; Hudak, Andrew; Dong, Huiping; Homer, Robert J.; Ma, Shuangge; Iwasaki, Akiko
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Howard Hughes Medical Institute
摘要：Licensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently induce local mucosal immune responses. Here, we describe an intranasal booster strategy with unadjuvanted recombinant hemagglutinin (HA) following initial messenger RNA-lipid nanoparticle (mRNA-LNP) vaccination, Prime and HA. This regimen establishes highly protective HA-specific mucosal immune memory responses in the respiratory tract. Intranasal HA boosters resulted...
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作者：Ren, Jie; Duan, Yaoyuan; Li, Ruoqi; Zhang, Xin; Shi, Yanfei; Zhou, Shiyun; Xie, Kaidong; Wu, Xiaomeng; Irish, Vivian F.; Deng, Xiuxin; Zhang, Fei; Guo, Wenwu
作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Yale University; Yale University
摘要：A common characteristic of thorns, prickles, and spines is a hardened and sharp tip. This feature complicates cultivation and postharvest processing for many crops, yet the molecular mechanisms governing this specific sclerification process remain unclear. By genome editing screening, we identified a MYB family gene named SHORT and SOFT THORN 1 (SST1) that specifically promotes the development of sclerenchyma cells at Citrus thorn tips. CRISPR-Cas9 editing of SST1 results in the formation of s...
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作者：Yang, Ge; Wang, Dong; Liu, Bin
作者单位：University of Minnesota System
摘要：Borna disease virus 1 (BoDV-1), an emerging zoonotic pathogen from the Bornaviridae family, is neurotropic and can infect a variety of mammalian hosts, including humans. Linked to severe encephalitis and high mortality, BoDV-1 currently lacks licensed treatments or vaccines. The BoDV-1 polymerase complex, comprising the large (L) and phosphoprotein (P) subunits, is crucial for viral replication and transcription, making it a promising target for antiviral intervention. Here, we present the cry...
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作者：Pinkas, Zoe; Khersonsky, Olga; Berman, Paula; Kuzmich, Nikolay; Rogachev, Ilana; Fleishman, Sarel J.; Aharoni, Asaph
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：Despite extensive study of its chemical composition and long history of medicinal use, the occurrence of glycosylated cannabinoid derivatives in Cannabis sativa has not been documented to date. Here, we identified glycosylated cannabinoids and their common intermediate olivetolic acid (OA) in various C. sativa tissues and cultivars. We moreover ating activity. Enhancing the water solubility of cannabinoids through glycosylation holds potential for pharmaceutical development and cosmetic applic...
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作者：Miranda, Joao A. I.; Vital, Marcia F. S.; Carrolo, Margarida; Quintela, Antonio; Pinto, Francisco R.
作者单位：BIOISI; Universidade de Lisboa; Universidade de Lisboa; Universidade de Lisboa; Hospital Santa Maria
摘要：Cancer is driven by the accumulation of somatic mutations, including driver mutations that confer a selective advantage to cancer cells. Driver proteins operate within complex interaction networks, and their activity is conditioned by neighbor proteins. Understanding the interplay between driver mutations and the expression of their neighbor proteins can provide insights into cancer biology and potential therapeutic targets. We assessed associations between expression of neighbor proteins and ...
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作者：Song, Jiqiang; Qi, Zihan; He, Chun; Luo, Guilin; Yuan, Bo; Xiao, Shan; Yang, Yi; Wang, Fang; Ye, Gongyin; Fang, Qi; Yan, Zhichao
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Nanjing Agricultural University
摘要：Gene duplication, followed by neofunctionalization, is a key mechanism driving the emergence of evolutionary novelties. Despite its significance, the molecular and functional processes underlying this phenomenon remain incompletely understood. By tracing the evolutionary history of cysteine-S-conjugate beta-lyase genes within the kynurenine aminotransferase family, we identified a gene duplication event in parasitoid wasps of the Chalcidoidea superfamily. Notably, a single-copy, highly conserv...
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作者：Violante, Sara; Kyaw, Aye; Kouatli, Lana; Paladugu, Kaushik; Apostolakis, Lauren; Jenks, Macy; Johnson, Amy; Sheldon, Ryan D.; Whitten, Douglas; Schilmiller, Anthony L.; Visconti, Pablo E.; Cross, Justin R.; Levin, Lonny R.; Buck, Jochen; Balbach, Melanie
作者单位：Memorial Sloan Kettering Cancer Center; Michigan State University; Van Andel Institute; Michigan State University; University of Massachusetts System; University of Massachusetts Amherst; Cornell University; Weill Cornell Medicine
摘要：Prior to ejaculation, mammalian sperm are stored in the epididymis in a resting metabolic state. Upon ejaculation, sperm must alter their metabolism to generate the energy needed to support the motility and maturation process known as capacitation to reach and fertilize the oocyte. How sperm regulate the capacitation-induced increase in carbon flux is unknown. Here, we use 13C stable isotope labeling in mouse sperm isolated from the cauda epididymis to follow glucose metabolism through central...
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作者：Martinez-Corral, Rosa; Friedrich, Dhana; Fromel, Robert; Velten, Lars; Gunawardena, Jeremy; DePace, Angela H.
作者单位：Harvard University; Harvard Medical School; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; Harvard University; Howard Hughes Medical Institute; Bayer AG; Pompeu Fabra University
摘要：Transcription factors (TFs) can be both activators and repressors of gene transcription. This can manifest as duality, where the transcriptional response increases (activation) with TF concentration in one context but decreases (repression) in another context, or as nonmonotonicity, where, in the same context, the response increases in part of the concentration range and decreases outside that range. Here we use biophysical models of gene regulation to investigate how duality and nonmonotonici...
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作者：Saviola, Francesca; Tambalo, Stefano; Beghini, Laura; Ferrari, Asia; Cassone, Barbara; van de Ville, Dimitri; Jovicich, Jorge
作者单位：University of Trento; University of Brescia; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Turin; University of Turin; Norwegian University of Science & Technology (NTNU); University of Brescia; University of Milano-Bicocca; University of Geneva
摘要：The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism supporting cognitive processes. Yet, little is understood about how EIB shifts with engaging cognitive load and its impact on functional connectivity dynamics. Here, we combined time-resolved functional magnetic resonance spectroscopy and magnetic resonance imaging to investigate temporal profiles of the reciprocal modulation between EIB and functiona...
