39期

最新文章

• Exploring the sub-Neptune frontier with JWST AI翻译
  作者：Madhusudhan, Nikku; Holmberg, Mans; Constantinou, Savvas; Cooke, Gregory J.
  作者单位：University of Cambridge; Space Telescope Science Institute
  摘要：Sub-Neptune planets, with sizes and masses between those of Earth and Neptune, dominate the exoplanet population. Sub-Neptunes are expected to be the most diverse family of the exoplanet population, potentially including rocky gas dwarfs, water worlds, and mini-Neptunes, with a wide range of atmospheric, surface, and interior conditions. With no analogue in the solar system, these planets open fundamental questions in planetary processes, origins, and habitability, and present avenues in the s...
• Strategic planning of prevention and surveillance for emerging diseases and invasive species AI翻译
  作者：Wang, Jue; Hanley, Brenda J.; Thompson, Noelle E.; Gong, Yu; Walsh, Daniel P.; Gonzalez-Crespo, Carlos; Huang, Yitong; Booth, James G.; Caudell, Joe N.; Miller, Landon A.; Schuler, Krysten L.
  作者单位：Queens University - Canada; Cornell University; Cornell University; University of Montana System; United States Department of the Interior; University of Montana; United States Geological Survey; University of California System; University of California Davis; Cornell University
  摘要：Emerging infectious diseases and biological invasions pose increasing threats to public and ecosystems health. Proactive measures-such as prevention and surveillance taken before initial detection of the pathogen or species-are essential to ensure minimal spread prior to first detection. We developed an optimization model to determine where, when, and how much effort should be allocated to prevention versus surveillance. The model accounts for imperfect detection, system dynamics, spatial hete...
• Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons AI翻译
  作者：Rodriguez, Juan D.; Reeves, Monica N.; Chavez, Sindy R.; Wang, Hsiao- Lin V.; Chavez, Jaely Z.; Rastogi, Rhea; Sun, Liyang I.; Roberson, Mackenzie S.; Preston, Elicia A.; Massenburg, Zaynab; Cruz, Kiani N.; Chadha, Madhav S.; Hill, Emily J.; Soares, Miguel L.; Corces, Victor G.; Carpenter, Brandon S.; Schmeichel, Karen L.; Murray, John I.; Katz, David J.
  作者单位：Emory University; Emory University; University System of Georgia; Kennesaw State University; University of Pennsylvania; Pennsylvania Medicine
  摘要：How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown. To address this question, we took advantage of the invariant embryonic lineage and adult nervous system in Caenorhabditis elegans to investigate a double mutant between spr-5/Lsd1/Kdm1a (H3K4me1/2 demethylase) and met-2/Setdb1/Kmt1e (H3K9 methyltransferase). We demonstrate that spr-5; met-2 double mutant worms have a severe chemotaxis defect caused by the ectopic expression of germline genes in somatic ti...
• Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility (vol 111, E89, 2013) AI翻译
  作者：Wang, Zhongyuan; Wu, Yanping; Wang, Haifeng; Zhang, Yangqing; Mei, Lin; Fang, Xuexun; Zhang, Xudong; Zhang, Fang; Chen, Hongbo; Liu, Ying; Jiang, Yuyang; Sun, Shengnan; Zheng, Yi; Li, Na; Huang, Laiqiang
• Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice AI翻译
  作者：de Souza Leite, Felipe; Lambert, Matthias R.; Zhang, Tracy Yuanfan; Conner, James R.; Paulo, Joao A.; Furtado Oliveira, Sheldon; Thakurta, Sanjukta Guha; Bowles, Jennifer; Gussoni, Emanuela; Gygi, Steven P.; Widrick, Jeffrey J.; Kunkel, Louis M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To clarify the underlying biology of JAG1 overexpression in dystrophic muscles, we gener...
• Severe water crisis in southern Spain under expanding irrigated agriculture: A multidimensional drought analysis AI翻译
  作者：Junquera, Victoria; Hormaza, Jose I.; Rubenstein, Daniel I.; Levin, Simon A.; Perez, Inaki Vadillo; Gavilan, Pablo Jimenez
  作者单位：University of Bern; Princeton University; Princeton University; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Malaga; CSIC-UMA - Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora (IHSM); Universidad de Malaga
  摘要：The Axarqu & iacute;a region in southern Spain, a hotspot of avocado and mango production in Europe, underwent an extreme water crisis in 2019-2024. Reservoir levels dropped below the 8% outlet threshold and groundwater in the main aquifer dropped to sea level in several locations, risking seawater intrusion. Socioeconomic impacts ranged from substantial crop losses to a potential long-term decline in regional economic viability. We examine the main drivers of this crisis using a coupled human...
• Targeting endothelial ERG to mitigate vascular regression in retinopathies AI翻译
  作者：Ma, Eric; Schafer, Christopher M.; Xie, Jun; Rudenko, Yelyzaveta; Knapp, John T. H.; Randi, Anna M.; Birdsey, Graeme M.; Griffin, Courtney T.
  作者单位：Oklahoma Medical Research Foundation; Imperial College London; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma Health Sciences Center; University of Central Oklahoma
  摘要：Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which an initial loss of retinal capillaries leads to damaging tissue ischemia followed by a compensatory neovascularization response that generates pathological capillaries in the eye. Using a mouse model of ROP and samples from DR patients, we found that the highly homologous and homeostatic erythroblast transformation-specific (ETS) family transcription factors ETS-related gene (ERG) and Friend leukemia i...
• Reply to Fleming: Not a gossamer web AI翻译
  作者：Santer, Benjamin D.; Solomon, Susan; Thompson, David W. J.; Fu, Qiang; Li, Yaowei
  作者单位：Woods Hole Oceanographic Institution; University of East Anglia; Massachusetts Institute of Technology (MIT); Colorado State University System; Colorado State University Fort Collins; University of Washington; University of Washington Seattle
• CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma AI翻译
  作者：Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A.; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L.; Qin, Wenxin; Gao, Qiang; Bernards, Rene; Jin, Haojie
  作者单位：Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Tongji University; Fudan University; Fudan University; Sun Yat Sen University; State Key Lab Oncology South China; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency in CCA. Compound screens revealed that the VCP inhibitor CB-5339 potently suppresses CCA proliferation in a panel of patient-derived organoids by inducing cellular senescence. It is known that senescent cells persist, and this can contribute to therapy resis...