39期

最新文章

• Riverine heat waves on the rise, outpacing air heat waves AI翻译
  作者：Sadayappan, Kayalvizhi; Li, Li
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：While air heat waves often grab headlines, riverine heat waves have gone quietly unnoticed because rivers are commonly perceived as cool refuges. Analysis of riverine heat waves has been hindered by fragmented datasets, despite a proliferation in water-temperature monitoring with sensors and satellites. Here, we analyze riverine heat wave events by training one single deep learning (long short-term memory) model and reconstructing consistent and continuous daily water temperatures (WT) in 1471...
• The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size AI翻译
  作者：Calvo, Cristofer; Swoboda, Casey O.; Morales, Fabian Montecino-; Nagar, Siddhant; Petrany, Michael J.; Sun, Chengyi; Durumutla, Hima Bindu; Quattrocelli, Mattia; Millay, Douglas P.
  作者单位：Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
  摘要：The development and maintenance of the neuromuscular junction (NMJ) requires reciprocal signals between the nerve terminals and multinucleated skeletal muscle fibers (myofibers). This interaction drives highly specialized transcription in the subsynaptic or NMJ myonuclei within mature myofibers leading to clustering of acetylcholine receptors (AChRs). Here, we utilized single-nucleus RNA sequencing (snRNA-seq) to delineate the transcriptional response of myonuclei to denervation. Through snRNA...
• Strategic planning of prevention and surveillance for emerging diseases and invasive species AI翻译
  作者：Wang, Jue; Hanley, Brenda J.; Thompson, Noelle E.; Gong, Yu; Walsh, Daniel P.; Gonzalez-Crespo, Carlos; Huang, Yitong; Booth, James G.; Caudell, Joe N.; Miller, Landon A.; Schuler, Krysten L.
  作者单位：Queens University - Canada; Cornell University; Cornell University; United States Department of the Interior; United States Geological Survey; University of Montana System; University of Montana; University of California System; University of California Davis; Cornell University
  摘要：Emerging infectious diseases and biological invasions pose increasing threats to public and ecosystems health. Proactive measures-such as prevention and surveillance taken before initial detection of the pathogen or species-are essential to ensure minimal spread prior to first detection. We developed an optimization model to determine where, when, and how much effort should be allocated to prevention versus surveillance. The model accounts for imperfect detection, system dynamics, spatial hete...
• RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation AI翻译
  作者：Li, Hui; Wang, Ling; Lei, Zhen; Biacsi, Anna-Sara; Jeong, Dong-Hoon; Cho, Jungnam
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; CRUK Cambridge Institute; Cancer Research UK; University of Cambridge; Duke University; Yale University; Durham University; Hallym University; Hallym University
  摘要：Transposable elements (TEs), ubiquitous mobile DNAs, are largely repressed by cellular mechanisms such as epigenetic silencing and RNA decay, yet some retain the ability to transpose. The Arabidopsis long terminal repeat retrotransposon Copia93, also known as Evade, exhibits exceptionally high transpositional activity, but the mechanism underlying its extraordinary mobility remains unclear. Here, we identify an Element for Nuclear Expression (ENE) motif within the 3 ' UTR of Evade that forms a...
• Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance AI翻译
  作者：Le Mouellic, Wendy; Levillain, Florence; Wu, Ting - Di; Caouaille, Maxime; Bousso, Philippe; Poquet, Yannick; Neyrolles, Olivier
  作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper understanding of Mycobacterium tuberculosis metabolism could uncover specific vulnerabilities and inform the development of new treatments. Sulfur, essential for bacterial growth and survival, fuels key pathways including redox buffering and coenzyme production. Although previous studies suggest that M. tuberculosis utilizes various substrates to meet it...
• Novelty as a drive of human exploration in complex stochastic environments AI翻译
  作者：Modirshanechi, Alireza; Lin, Wei-Hsiang; Xu, He A.; Herzog, Michael H.; Gerstner, Wulfram
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Max Planck Society
  摘要：In order to find extrinsic rewards, humans explore their environment even if exploration requires several intermediate, reward-free decisions. It has been hypothesized that intrinsic rewards, such as novelty, surprise, or information gain, guide this reward-free exploration. However, in artificial agents, different intrinsic reward signals induce exploration strategies that respond differently to stochasticity. In particular, some strategies are vulnerable to the noisy TV problem, i.e., an att...