39期

最新文章

• Versatile Xenopus tropicalis model with targeted integration of human BRAFV600E AI翻译
  作者：Ran, Rensen; Li, Lanxin; Chen, Peng; Li, Shuai; Wang, Peng; Zhu, Zhenpeng; Wang, Xiran; Chen, Yonglong; Hang, Jing; Liang, Weizheng
  作者单位：Southern University of Science & Technology; Peking University; Xi'an Medical University; Guangdong Medical University; Hebei North University; Hebei North University
  摘要：Targeting exogenous gene integrations in animals often exhibits low efficiency, limiting the development of gene knock-in models. Theoretically, by screening founder generation individuals based on the cell phenotypes resulting from gene knock-ins and leveraging the high fecundity of animals, heritable descendants with targeted knock-ins can be efficiently generated. Therefore, we utilized the high fecundity of Xenopus tropicalis and easily observable pigment phenotypes to construct a BRAFV600...
• Toward a unified taxonomy of information dynamics via Integrated Information Decomposition AI翻译
  作者：Mediano, Pedro A. M.; Rosas, Fernando E.; Luppi, Andrea I.; Carhart-Harris, Robin L.; Bor, Daniel; Seth, Anil K.; Barrett, Adam B.
  作者单位：Imperial College London; University of London; University College London; University of Sussex; Imperial College London; Imperial College London; University of Oxford; University of Cambridge; University of Cambridge; University of California System; University of California San Francisco; University of London; Queen Mary University London; University of Cambridge; Canadian Institute for Advanced Research (CIFAR); University of Sussex
  摘要：Our ability to understand and control complex systems of many interacting parts remains limited. A key challenge is that we still do not know how best to describe-and quantify-the many-to-many dynamical interactions that characterize their complexity. To address this limitation, we introduce the mathematical framework of Integrated Information Decomposition, or IID. IID provides a comprehensive framework to disentangle and characterize the information dynamics of complex multivariate systems. ...
• Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer AI翻译
  作者：Alencar, Gabriel F.; Mohamed, Asmaa O.; Burnett, Madison G.; St Jean, Samantha; Nelson, Anders R.; Su, Yapeng; Voillet, Valentin; Bates, Breanna M.; Suarez, Magdalia Rodgers; Ruskin, Susan L.; Trieu, Lam; Lam, Jennifer L.; Bekiranov, Stefan; Gottardo, Raphael; Greenberg, Philip D.; Anderson, Kristin G.
  作者单位：University of Virginia; University of Virginia; Fred Hutchinson Cancer Center; University of Virginia; University of Virginia; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of Virginia; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Swiss Institute of Bioinformatics; University of Virginia
  摘要：The five-year survival rate for ovarian cancer patients remains below 50%, underscoring the need for innovative therapies. One promising approach involves engineering T cells to specifically target proteins uniquely overexpressed in tumors, thereby controlling tumor growth without toxicity to healthy tissues. Mesothelin (MSLN) contributes to the malignant and invasive phenotype in ovarian cancer and has limited expression in healthy cells, making it a candidate immunotherapy target. Our previo...
• A diverse family of bacterial deubiquitinases is defined by the Coxiella burnetii effector EmcB AI翻译
  作者：Duncan-Lowey, Jeffrey K.; Roy, Craig R.
  作者单位：Yale University
  摘要：The obligate intracellular pathogen Coxiella burnetii encodes a deubiquitinase called EmcB that prevents signaling by the host immune sensor Retinoic acid Inducible Gene I (RIG-I). The evolutionary relationship between EmcB and other deubiquitinases is currently unknown. Here, we show that EmcB defines a broad family of bacterial deubiquitinases divergently evolved from the eukaryotic Ovarian Tumor (OTU) family of deubiquitinases. Our data indicate that the emcB gene has an internal gene rearr...
• The potential impacts of human genetics on virus emergence AI翻译
  作者：Langlois, Ryan A.; Casanova, Jean- Laurent
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Rockefeller University; Howard Hughes Medical Institute; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
  摘要：Human monogenic traits can confer resistance to viral disease in infected individuals. Enhanced susceptibility can be driven directly by mutations in genes essential for control of the virus or indirectly via the production of autoantibodies against components of host defense. While the impact of viruses on individuals carrying these genotypes permitted their identification and has been amply studied, little is known about the impact of these human genotypes on the natural history of viruses, ...
• Spin-resolved imaging of atomic-scale helimagnetism in mono-and bilayer NiI2 AI翻译
  作者：Miao, Mao-Peng; Liu, Nanshu; Zhang, Wen-Hao; Zhou, Jian-Wang; Wang, Dao-Bo; Wang, Cong; Ji, Wei; Fu, Ying-Shuang
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Renmin University of China; Renmin University of China; Southwest University - China
  摘要：Noncollinear magnetic orders in monolayer van der Waals magnets are crucial for probing delicate magnetic interactions under minimal spatial constraints and advancing miniaturized spintronic devices. Despite their significance, achieving atomic-scale identification remains challenging. In this study, we utilized spin-polarized scanning tunneling microscopy and density functional theory calculations to identify spin-spiral orders in mono-and bilayer NiI2, grown on graphene-covered SiC(0001) sub...
• IFN- inducible human phospholipid scramblase 1 (PLSCR1) protein restricts HIV-1 infection by inhibiting membrane fusion AI翻译
  作者：Liu, Yajie; Li, Pei; Zheng, Yi - Min; Hikichi, Yuta; Ablan, Sherimay D.; Freed, Eric O.; Liu, Shan - Lu
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Human phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (ISG) that inhibits viral infections through various mechanisms. Here, we identify PLSCR1 as a host restriction factor that inhibits HIV-1 entry by impairing membrane fusion mediated by the envelope glycoprotein (Env). Using multiple cell types including the human SupT1 T cell line and purified CD4+T cells, we demonstrate that PLSCR1 inhibits the replication of HIV-1 with diverse tropisms and subtypes, as well as HIV-2 a...
• In situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation AI翻译
  作者：Yue, Jian; Heydari, Samira; Park, Donghyun; Chetrit, David; Tachiyama, Shoichi; Guo, Wangbiao; Botting, Jack M.; Wu, Shenping; Roy, Craig R.; Liu, Jun
  作者单位：Yale University; Yale University; Yale University; Scripps Research Institute; Johns Hopkins University
  摘要：The Dot/Icm machine of Legionella pneumophila is among the most versatile type IV secretion systems (T4SSs), capable of translocating more than 330 distinct effector proteins across the bacterial envelope into host cells. Assembly and function of the system require at least 27 Dot and Icm proteins, yet its architecture and activation mechanism remain poorly understood at the molecular level. Here, we deploy in situ single-particle cryoelectron microscopy to determine near-atomic structures of ...
• Action painting under spectroscopic light: Excited-state exchange interactions behind the vibrant blue in Jackson Pollock's Number 1A, 1948 AI翻译
  作者：Heyer, Alexander J.; Haddad, Abed; Scott, Racquel; Kowach, Glen; Solomon, Edward I.
  作者单位：Stanford University; City University of New York (CUNY) System; City College of New York (CUNY); Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：Number 1A, 1948 by Jackson Pollock is a quintessential example of his action painting technique where ropes of color, drips of black, and pools of white coalesce into the layered dynamism that defines his style. While past work has identified the red and yellow pigments that form part of his core palette, the vibrant blue in the painting has remained unassigned. In this study resonance Raman spectroscopy is used to assign the blue in the painting as manganese blue. This assignment offers criti...
• Dual Bmp- negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number AI翻译
  作者：Patel, Rashmi; Mackem, Susan
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by interactions between the two major signaling centers that organize digit pattern and growth, the Sonic hedgehog (Shh)-expressing Zone of Polarizing Activity (ZPA) and the Fgf-expressing Apical Ectodermal Ridge (AER) ectoderm. Negative short-range effects of Shh on the immediately overlying AER limit its posterior extent and function, either by direct Shh...