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• Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity AI翻译
  作者：Furth, Noa; Cohen, Niv; Spitzer, Avishay; Salame, Tomer- Meir; Dassa, Bareket; Mehlman, Tevie; Brandis, Alexander; Moussaieff, Arieh; Friedmann-Morvinski, Dinorah; Castro, Maria G.; Fortin, Jerome; Suva, Mario L.; Tirosh, Itay; Erez, Ayelet; Ron, Guy; Shema, Efrat
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Hebrew University of Jerusalem; Tel Aviv University; University of Michigan System; University of Michigan; McGill University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Hebrew University of Jerusalem
  摘要：Malignant gliomas are heterogeneous tumors, mostly incurable, arising in the central nervous system (CNS) driven by genetic, epigenetic, and metabolic aberrations. Mutations in isocitrate dehydrogenase (IDH1/2mut) enzymes are predominantly found in low- grade gliomas and secondary high- grade gliomas, with IDH1 mutations being more prevalent. Mutant-IDH1/2 confers a gain- of- function activity that favors the conversion of a- ketoglutarate (ox- KG) to the oncometabolite 2- hydroxyglutarate (2-...
• Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m AI翻译
  作者：Johnson, Nicole A.; Dickenson, Jessica A.; Mackenzie, Benjamin W. L.; Isakovich, Rodion; Kalker, Anne; Bouten, Janne; Strzalkowski, Nicholas D. J.; Harman, Taylor S.; Kunwar, Ajaya J.; Thakur, Nilam; Dhungel, Sunil; Sherpa, Nima; Bigham, Abigail W.; Brutsaert, Tom D.; Day, Trevor A.; Holmstroem, Pontus
  作者单位：Mount Royal University; Radboud University Nijmegen; Ghent University; Syracuse University; Mid-Sweden University
  摘要：With over 14 million people living above 3,500 m, the study of acclimatization and adaptation to high altitude in human populations is of increasing importance, where exposure to high altitude (HA) imposes a blood oxygenation and acid-base challenge. A sustained and augmented hypoxic ventilatory response protects oxygenation through ventilatory acclimatization, but elicits hypocapnia and respiratory alkalosis. A subsequent renally mediated compensatory metabolic acidosis corrects pH toward bas...
• The carnivorous plant Genlisea harnesses active particle dynamics to prey on microfauna AI翻译
  作者：Martin-Roca, Jose; Barriuso, G. C. Miguel; Fernandez, Raul Martinez; Giuliano, Camila Betterelli; Zhang, Rongjin; Valeriani, Chantal; Wilson, Laurence G.
  作者单位：Complutense University of Madrid; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of York - UK
  摘要：Carnivory in plants is an unusual trait that has arisen multiple times, independently, throughout evolutionary history. Plants in the genus Genlisea are carnivorous and feed on microorganisms that live in soil using modified subterranean leaf structures (rhizophylls). A surprisingly broad array of microfauna has been observed in the plants' digestive chambers, including ciliates, amoebae, and soil mites. Here, we show, through experiments and simulations, that Genlisea exploit active matter ph...
• RNAi of the elastomeric protein resilin reduces jump velocity and resilience to damage in locusts AI翻译
  作者：Rogers, Stephen M.; Cullen, Darron A.; Labonte, David; Sutton, Gregory P.; Vanden Broeck, Jozef J. M.; Burrows, Malcolm
  作者单位：University of Cambridge; University of Lincoln; KU Leuven; University of Hull; Imperial College London; University of Cambridge
  摘要：Resilin, an elastomeric protein with remarkable physical properties that outperforms synthetic rubbers, is a near- ubiquitous feature of the power amplification mechanisms used by jumping insects. Catapult- like mechanisms, which incorporate elastic energy stores formed from a composite of stiff cuticle and resilin, are frequently used by insects to translate slow muscle contractions into rapid- release recoil movements. The precise role of resilin in these jumping mechanisms remains unclear, ...
• Multitude of glasses of water AI翻译
  作者：Sciortino, Francesco
  作者单位：Sapienza University Rome
• Elucidation of a distinct photoreduction pathway in class II Arabidopsis thaliana photolyase AI翻译
  作者：Zhou, Zhongneng; Chen, Zijing; Kang, Xiu-Wen; Ding, Bei; Zou, Shuhua; Tang, Siwei; Zhou, Yalin; Wang, Bingyao; Zhong, Dongping
  作者单位：Shanghai Jiao Tong University
  摘要：Class II photolyases (PLs) are a distant subclade in the photolyase/cryptochrome superfamily, displaying a unique Trp-Tyr tetrad for photoreduction and exhibiting a lower quantum yield (QY) of DNA repair (49%) than class I photolyases (82%) [M. Zhang, L. Wang, S. Shu, A. Sancar, D. Zhong, Science 354, 209-213 (2016)]. Using layer-by-layer mutant design and femtosecond spectroscopy, we have successfully determined the rates of electron transfer and proton transfer, driving force, and reorganiza...
• Personality differences between birth order categories and across sibship sizes AI翻译
  作者：Ashton, Michael C.; Lee, Kibeom
  作者单位：Brock University; University of Calgary
  摘要：We examined associations of self- reports on the HEXACO Personality Inventory-Revised (HEXACO-PI-R) with birth order category and sibship size, controlling for participant sex and age. In a first sample (N > 700,000 online adults, mainly from English- speaking countries), Honesty- Humility and Agreeableness both showed the highest means for middle-borns, followed in order by last-borns (youngests), firstborns (oldests), and only children, with differences between middles and onlys of d >= 0.20...
• Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs AI翻译
  作者：Borniego, M. Lucia; Singla-Rastogi, Meenu; Baldrich, Patricia; Sampangi-Ramaiah, Megha Hastantram; Karimi, Hana Zand; Mcgregor, Madison; Meyers, Blake C.; Innes, Roger W.
  作者单位：Indiana University System; Indiana University Bloomington; Donald Danforth Plant Science Center; University of California System; University of California Davis; University of Missouri System; University of Missouri Columbia; University of California System; University of California Davis
  摘要：Transgenic expression of a double- stranded RNA in plants can induce silencing of homologous mRNAs in fungal pathogens. Although such host- induced gene silencing is well documented, the molecular mechanisms by which RNAs can move from the cytoplasm of plant cells across the plasma membrane of both the host cell and fungal cell are poorly understood. Indirect evidence suggests that this RNA transfer may occur at a very early stage of the infection process, prior to breach of the host cell wall...
• Tetrameric PilZ protein stabilizes stator ring in complex flagellar motor and is required for motility in Campylobacter jejuni AI翻译
  作者：Chen, Yuanyuan; Tachiyama, Shoichi; Li, Yuqian; Feng, Xueyin; Zhao, Hang; Wu, Yanmin; Guo, Yu; Tejero, Maria Lara -; Hua, Canfeng; Liu, Jun; Gao, Beile
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Yale University; Yale University; Henan University
  摘要：Rotation of the bacterial flagellum, the first identified biological rotary machine, is driven by its stator units. Knowledge gained about the function of stator units has increasingly led to studies of rotary complexes in different cellular pathways. Here, we report that a tetrameric PilZ family protein, FlgX, is a structural component underneath the stator units in the flagellar motor of Campylobacter jejuni. FlgX forms a stable tetramer that does not bind cyclic di- GMP (c- di- GMP), unlike...
• Oppositional and competitive instigation of hippocampal synaptic plasticity by the VTA and locus coeruleus AI翻译
  作者：Hagena, Hardy; Manahan-Vaughan, Denise
  作者单位：Ruhr University Bochum
  摘要：The novelty, saliency, and valency of ongoing experiences potently influence the firing rate of the ventral tegmental area (VTA) and the locus coeruleus (LC). Associative experience, in turn, is recorded into memory by means of hippocampal synaptic plasticity that is regulated by noradrenaline sourced from the LC, and dopamine, sourced from both the VTA and LC. Two persistent forms of synaptic plasticity, long- term potentiation (LTP), and long- term depression (LTD) support the encoding of di...