7期

最新文章

• Self-assembled proteomimetic (SAP) with antibody- like binding from short PNA-peptide conjugates AI翻译
  作者：Brennecke, Benjamin; Civili, Beatrice; Sabale, Pramod M.; Barluenga, Sofia; Meyer, Benjamin; Winssinger, Nicolas
  作者单位：University of Geneva; University of Geneva
  摘要：Affinity proteins based on a three-helix bundle (affibodies, alphabodies, and computationally de novo designed ones) have been shown to be a general platform to discover binders with properties reminiscent of antibodies, combining high target specificity with affinities reaching well below the nanomolar. Herein, we report a strategy, coined self-assembled proteomimetic (SAP), to mimic such three-helix bundle architecture with a hybridization-enforced two-helix coiled coil that is obtained by t...
• Thermoelastic twisting-assisted crystal jumping based on a self- healing molecular crystal AI翻译
  作者：Wang, Zhihua; Cheng, Puxin; Han, Wenqing; Shi, Rongchao; Xu, Jian; Zheng, Yongshen; Xu, Jialiang; Bu, Xian-He
  作者单位：Nankai University; Sinopec
  摘要：Adaptive crystals have attracted significant attention from solid- state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, and actuators. Among them, thermosalient crystals are particularly favored thanks to their efficient energy conversions and rapid responses. However, the mechanisms for the mechanical responses of thermosalient crystals remain largely unclear. Herein we demonstrate that thermosalient effects of molecular crystals could be dri...
• SNORD80-guided 2'- O- methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses AI翻译
  作者：Xu, Liang; Zhao, Xiao Hong; Zhang, Yuan Yuan; Zhang, Meng Yao; Zhang, Long Yue; Ye, Kai Hong; Teng, Liu; Han, Man Man; Yue, Yi Meng; Yang, Jiezhen; Ogle, Rachel; Netherton, Jacob; Tang, Deng; Lan, Siqi; Baker, Mark; Ye, Yan; Liu, Tao; Wang, Yu Fang; Zhang, Xu Dong; Fan, Tianli; Jin, Lei
  作者单位：University of Newcastle; Zhengzhou University; Fudan University; Sichuan University; Anhui Medical University; Children's Cancer Institute; University of New South Wales Sydney; Children's Medical Research Institute - Australia; Zhengzhou University; University of Newcastle
  摘要：The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress. The 2 '- O- methylation at the A496 site, located within a segment of GAS5 complementing the conserve...
• Bioinspired nanogels as cell- free DNA trapping and scavenging organelles for rheumatoid arthritis treatment (vol 120, e2303385120, 2023) AI翻译
  作者：Zhu, Haofang; Kong, Bin; Che, Junyi; Zhao, Yuanjin; Sun, Lingyun
• Persistence selection between simulated biogeochemical cycle variants for their distinct effects on the Earth system AI翻译
  作者：Boyle, Richard A.; Moody, Edmund R. R.; Babcock, Gunnar; Mcshea, Daniel W.; alvarez-Carretero, Sandra; Lenton, Timothy M.; Donoghue, Philip C. J.
  作者单位：University of Exeter; University of Bristol; Cornell University; Duke University
  摘要：The average long- term impact of Darwinian evolution on Earth's habitability remains extremely uncertain. Recent attempts to reconcile this uncertainty by Darwinizing nonreplicating biogeochemical processes subject to persistence- based selection conform with the historicity of the geochemical record but lack mechanistic clarity.Here, we present a theoretical framework showing how: 1) A biogeochemical cycle- biota- variant (CBV) can be defined non- arbitrarily as one biologically facilitated p...
• Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel AI翻译
  作者：Loiodice, Melanie; Drula, Elodie; Mciver, Zak; Antonyuk, Svetlana; Basle, Arnaud; Lima, Marcelo; Yates, Edwin A.; Byrne, Dominic P.; Coughlan, Jamie; Leech, Andrew; Mesdaghi, Shahram; Rigden, Daniel J.; Drouillard, Sophie; Helbert, William; Henrissat, Bernard; Terrapon, Nicolas; Wright, Gareth S. A.; Couturier, Marie; Cartmell, Alan
  作者单位：Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); INRAE; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); INRAE; University of York - UK; University of Liverpool; Newcastle University - UK; Keele University; University of York - UK; University of Liverpool; King Abdulaziz University; Technical University of Denmark; University of Essex; University of York - UK; University of York - UK
  摘要：Acidic glycans are essential for the biology of multicellular eukaryotes. To utilize them, microbial life including symbionts and pathogens has evolved polysaccharide lyases (PL) that cleave their 1,4 glycosidic linkages via a beta- elimination mechanism. PL family 33 (PL33) enzymes have the unusual ability to target a diverse range of glycosamino-glycans (GAGs), as well as the bacterial polymer, gellan gum. In order to gain more detailed insight into PL33 activities we recombinantly expressed...
• Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis AI翻译
  作者：Zhang, Xiaoyu; Liu, Yan; Wang, Ning
  作者单位：University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center
  摘要：Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lysine lactylation. Here, we report dynamic histone lactylation at histone H4- lysine 5 (K5),- K8, and- K12 during meiosis prophase I in mouse spermatogenesis. By profiling the genome-wide occupancy of histone H4- K8 lactylation...
• Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics AI翻译
  作者：Ikeda, Toma; Nojima, Tatsuya; Yamamoto, Souma; Yamada, Ryusei; Niwa, Tatsuya; Konno, Hiroki; Taguchi, Hideki
  作者单位：Institute of Science Tokyo; Tokyo Institute of Technology; Institute of Science Tokyo; Tokyo Institute of Technology; Kanazawa University; Kanazawa University; Kanazawa University
  摘要：According to classical Anfinsen's dogma, a protein folds into a single unique confor-mation with minimal Gibbs energy under physiological conditions. However, certain proteins may fold into two or more conformations from single amino acid sequences. Here, we designed a protein that adopts interconvertible alternative functional confor-mations, termed seesaw protein (SSP). An SSP was engineered by fusing GFP lacking the C- terminal beta- strand and dihydrofolate reductase (DHFR) lacking the N- ...
• Flake production: A universal by- product of primate stone percussion AI翻译
  作者：Proffitt, Tomos; Medeiros, Paula de Sousa; Martins, Waldney Pereira; Luncz, Lydia, V
  作者单位：Max Planck Society; Universidade do Algarve; Universidade Estadual de Montes Claros; Universidade Estadual de Montes Claros
  摘要：The evolution of stone tool technology marks a significant milestone in hominin devel-opment, enabling early humans to manipulate their environments. The oldest known evidence, dating to 3.3 Ma, indicates a combination of percussive and flake production activities. Studying the archaeological signature of percussive stone tool use in living primate provides a potential analog to the origin of stone flake technology in the hom-inin lineage. Here, we present a yellow- breasted capuchin (Sapajus ...
• Accelerated cell- type- specific regulatory evolution of the human brain ( vol 382 , eade951 , 2023) AI翻译
  作者：Joshy, Dennis; Santpere, Gabriel; Yi, Soojin V.