7期

最新文章

• Substrate and climate determine terrestrial litter decomposition AI翻译
  作者：Wu, Qiuxia; Ni, Xiangyin; Sun, Xinyao; Chen, Zihao; Hong, Songbai; Berg, Bjoern; Zheng, Mianhai; Chen, Ji; Zhu, Jingjing; Ai, Ling; Zhang, Yichen; Wu, Fuzhong
  作者单位：Fujian Normal University; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Ministry of Natural Resources of the People's Republic of China; Peking University; University of Helsinki; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Peking University
  摘要：Litter decomposition is a fundamental biogeochemical process for carbon flux and nutrient cycling in terrestrial ecosystems, yet the global variation in decomposition rates and their covariations with climate and substrate are not fully understood. Here, we synthesized a global dataset of 6,733 independent observations across six continents to illustrate the climatic and substrate controls over litter decomposi-tion. The average decomposition rates of various litter types ranged from 0.74 to 4...
• 撤稿声明: DAT (deacylating autotransporter toxin) from Bordetella parapertussis demyristoylates Gαi GTPases and contributes to cough AI翻译
  作者：Hiramatsu, Yukihiro; Nishida, Takashi; Ota, Natsuko; Tamaki, Yuki; Nugraha, Dendi K.; Horiguchi, Yasuhiko
• The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms AI翻译
  作者：Kharrat, Ons; Yamaryo-Botte, Yoshiki; Nasreddine, Rouba; Voisin, Sebastien; Aumer, Thomas; Cammue, Bruno P. A.; Madinier, Jean-Baptiste; Knobloch, Thomas; Thevissen, Karin; Nehme, Reine; Aucagne, Vincent; Botte, Cyrille; Bulet, Philippe; Landon, Celine
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); Universite de Orleans; Bayer AG; KU Leuven
  摘要：Fungal infections represent a significant global health concern, with a growing prevalence of antifungal drug resistance. Targeting glucosylceramides (GlcCer), which are func-tionally important glycosphingolipids (GSL) present in fungal membranes, represents a promising strategy for the development of antifungal drugs. GlcCer are associated with the antifungal activity of certain plant and insect defensins. The 44- residue ETD151 peptide, optimized from butterfly defensins, is active against s...
• In the shadow of antibiotics AI翻译
  作者：Rasouly, Aviram; Nudler, Evgeny
  作者单位：New York University; New York University; Howard Hughes Medical Institute
• The MutRS quorum-sensing system controls lantibiotic mutacinproduction in the human pathogenStreptococcus mutans AI翻译
  作者：Wyllie, Ryan M.; Jensen, Paul A.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Microbes use quorum-sensing systems to respond to ecological and environmentalchanges. In the oral microbiome, the pathogenic bacteriumStreptococcus mutansusesquorum-sensing to control the production of bacteriocins. These antimicrobial peptideskill off ecological competitors and allowS. mutansto dominate the microenvironmentof dental plaques and form dental caries. One class of bacteriocins produced byS. mutans, the lantibiotic mutacins, are particularly effective at killing due to theirbroad...
• Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling AI翻译
  作者：Avstrikova, Mariia; Rodriguez, Paula Milan; Burke, Sean M.; Hibbs, Ryan E.; Changeux, Jean-Pierre; Cecchini, Marco
  作者单位：Universites de Strasbourg Etablissements Associes; Centre National de la Recherche Scientifique (CNRS); Universite de Strasbourg; CNRS - Institute of Chemistry (INC); University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego; Universite PSL; Universite Paris Cite; Pasteur Network; College de France; Institut Pasteur Paris
  摘要：The alpha 7 nicotinic acetylcholine receptor is a pentameric ligand- gated ion channel that plays an important role in neuronal signaling throughout the nervous system. Its implication in neurological disorders and inflammation has spurred the development of numerous compounds that enhance channel activation. However, the therapeutic potential of these compounds has been limited by the characteristically fast desensitization of the alpha 7 receptor. Using recent high- resolution structures fro...
• Deliberation during online bargaining reveals strategic information AI翻译
  作者：Cotet, Miruna; Zhao, Wenjia Joyce; Krajbich, Ian
  作者单位：University System of Ohio; Ohio State University; University of Warwick; University of California System; University of California Los Angeles; University System of Ohio; Ohio State University
  摘要：A standard assumption in game theory is that decision- makers have preplanned strategies telling them what actions to take for every contingency. In contrast, nonstrategic decisions often involve an on- the- spot comparison process, with longer response times (RT) for choices between more similarly appealing options. If strategic decisions also exhibit these patterns, then RT might betray private information and alter game theory predictions. Here, we examined bargaining behavior to determine ...
• CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk AI翻译
  作者：Nguyen, Lien; Ajredini, Ramadan; Guo, Shu; Romano, Lisa E. L.; Tomas, Rodrigo F.; Bell, Logan R.; Ranum, Paul T.; Zu, Tao; Coronel, Monica Banez; Kelley, Chase P.; Redding-Ochoa, Javier; Nizamis, Evangelos; Melloni, Alexandra; Connors, Theresa R.; Gaona, Angelica; Thangaraju, Kiruphagaran; Pletnikova, Olga; Clark, H. Brent; Davidson, Beverly L.; Yachnis, Anthony T.; Golde, Todd E.; Lou, Xiangyang; Wang, Eric T.; Renton, Alan E.; Goate, Alison; Valdmanis, Paul N.; Prokop, Stefan; Troncoso, Juan C.; Hyman, Bradley T.; Ranum, Laura P. W.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Johns Hopkins University; Johns Hopkins Medicine; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Minnesota System; University of Minnesota Twin Cities; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：Alzheimer's disease (AD) affects more than 10% of the population >= 65 y of age, but the underlying biological risks of most AD cases are unclear. We show anti-poly-glycine-arginine (a-polyGR) positive aggregates frequently accumulate in sporadic AD autopsy brains (45/80 cases). We hypothesize that these aggregates are caused by one or more polyGR-encoding repeat expansion mutations. We developed a CRISPR/deactivated-Cas9 enrichment strategy to identify candidate GR-encoding repeat expansion m...
• Fast Interpretable Greedy-Tree Sums AI翻译
  作者：Tan, Yan Shuo; Singh, Chandan; Nasseri, Keyan; Agarwal, Abhineet; Duncan, James; Ronen, Omer; Epland, Matthew; Kornblith, Aaron; Yu, Bin
  作者单位：National University of Singapore; University of California System; University of California Berkeley; Microsoft; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, practitioners often use highly interpretable decision tree models, but these suffer from inductive bias against additive structure. To overcome this bias, we propose Fast Interpretable Greedy-Tree Sums (FIGS), which generalizes the Classification and Regression Trees (CART) algorithm to simultaneously ...
• Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis AI翻译
  作者：Dai, Yimei; Jiang, Yunyun; Cao, Canran; Xu, Yongtai; Lai, Siting; Zhu, Wenchao; Gao, Meng; Li, Feifei; He, Sicong; Xu, Jin
  作者单位：South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology; Southern University of Science & Technology
  摘要：Hemolysis induces tissue damage by releasing cellular contents into the plasma. It is widely accepted that hemolysis- derived toxic molecules are cleared by macrophages or metabolized in hepatocytes. In zebrafish, we found that scavenger endothelial cells (SECs), a specialized endothelium with remarkable endocytosis capability, engulf both macromolecular hemoglobin (Hb) and small molecular unconjugated bilirubin (UCB), two primary toxic byproducts of hemolysis. These engulfment processes are m...