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最新文章

• How and why funders support engaged research (vol 112, e2400931121, 2024) AI翻译
  作者：Bednarek, Angela T.; Miyamoto, Ben; Corbett, Kristin; Hudson, Charlotte; Scarrow, Gayle; Brass, Maeghan; DuMont, Kim; Holmes, Bev; Supplee, Lauren; McLean, Robert; Bhatia, Jaspal; Chappell, Shamira; Velez, Maggie Gorman; Kolavalli, Chhaya
  作者单位：University of Michigan; National Oceanic Atmospheric Admin (NOAA) - USA; University of Michigan System; University of Michigan
• Age-dependent cytokine surge in blood precedes cancer diagnosis AI翻译
  作者：Chen, Guangbo; Mohsin, Azam; Zheng, Hong; Rosenberg -Hasson, Yael; Padilla, Cindy; Sarin, Kavita Y.; Dekker, Cornelia L.; Grant, Philip; Maecker, Holden T.; Lu, Ying; Furman, David; Orr, Shai; Khatri, Purvesh; Davis, Mark M.
  作者单位：Medical College of Wisconsin; Medical College of Wisconsin; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Stanford University; Stanford University; Stanford Medicine; Buck Institute for Research on Aging; Stanford University; Stanford Medicine; University of Southern California; Technion Israel Institute of Technology; Rappaport Faculty of Medicine
  摘要：Aging is associated with increased variability and dysregulation of the immune system. We performed a system-level analysis of serum cytokines in a longitudinal cohort of 133 healthy individuals over 9 y. We found that cancer incidence is a major contributor to increased cytokine abundance variability. Circulating cytokines increase up to 4 y before a cancer diagnosis in subjects with age over 80 y. We also analyzed cytokine expression in 10 types of early-stage cancers from The Cancer Genome ...
• Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis AI翻译
  作者：Zhang, Wei; Li, Wenming; Du, Jun; Yang, Chen; Yu, Lei; Yang, Peng; Zhang, Haifeng; Wu, Zebin; Ge, Gaoran; Yang, Huilin; Geng, Dechun
  作者单位：Soochow University - China; Yangzhou University; Shanghai Jiao Tong University
  摘要：Redox imbalance contributes to aberrant osteoclastogenesis and osteoporotic bone loss. In this study, we observed lower Forkhead box protein O3 (FoxO3), a transcription factor associated with cellular oxidative stress, enhanced osteoclastogenesis in osteoporosis (OP). Single-cell RNA sequencing (scRNA-seq) analysis on the human femoral head indicated that FoxO3 is widely expressed in macrophages. Furthermore, Lysm-Cre;FoxO3f/f OVX mice showed increased reactive oxygen species (ROS), enhanced o...
• Deficiency in platelet 12-lipoxygenase exacerbates inflammation and disease severity during SARS-CoV-2 infection AI翻译
  作者：Andrade, Ana Claudia dos S. P.; Lacasse, Emile; Dubuc, Isabelle; Gudimard, Leslie; Gravel, Annie; Puhm, Florian; Campolina-Silva, Gabriel; Queiroz-Junior, Celso; Allaeys, Isabelle; Prunier, Julien; Wallen, Oumaima Azeggouar; Dumais, Elizabeth; Belleannee, Clemence; Droit, Arnaud; Flamand, Nicolas; Boilard, Eric; Flamand, Louis
  作者单位：Laval University; Laval University; Universidade Federal de Minas Gerais; Laval University; Laval University; Laval University Hospital; Laval University; Laval University; Laval University
  摘要：Platelets, known for maintaining blood balance, also participate in antimicrobial defense. Upon severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, platelets become hyperactivated, releasing molecules such as cytokines, granule contents, and bioactive lipids. The key effector biolipids produced by platelets include 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-hydroxyeicosatrienoic acid (12-HETrE), produced by 12-lipoxygenase (12-LOX), and prostaglandins and thromboxane, ...
• Hair cell apoptosis and deafness in Tmc1 mutations AI翻译
  作者：Beurg, Maryline; Konrad, Dakota Elle; Fettiplace, Robert
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Transmembrane channel-like protein 1 (TMC1), a pore-forming component of the mechano-electrical transducer (MET) channel in cochlear outer hair cells, is subject to numerous mutations causing deafness and hair cell death. We studied mice harboring semidominant mutations Tmc1 p.T416K, p.M412K, and p.D569N, which all display functional MET channels at postnatal day (P)6 but become deaf by P21. Early signs of concomitant hair cell apoptosis were assayed in neonatal Tmc1 mutants by labeling with C...
• Nonpathological inflammation drives the development of an avian flight adaptation (vol 120, e2219757120, 2023) AI翻译
  作者：Rashid, Dana J.; Sheheen, Joseph R.; Huey, Tori; Surya, Kevin; Sanders, Jackson B.; Horner, John R.; Voyich, Jovanka; Chapman, Susan C.
• Absence of water clusters in visible light interactions with the air-water interface AI翻译
  作者：Ahmed, Musahid; Lu, Wenchao
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
• Flycodes enable simultaneous preclinical analysis for dozens of antibodies in single cassette-dosed mice AI翻译
  作者：Walter, Justin D.; Beffinger, Michal; Egloff, Pascal; Zimmermann, Iwan; Hurlimann, Lea M.; Ackle, Fabian; Seifert, Matthias; Kobold, Sebastian; vom Berg, Johannes; Seeger, Markus A.
  作者单位：University of Zurich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：Protein therapeutics such as antibodies require in- depth in vivo characterization during development and consequently account for a large proportion of laboratory animal consumption in the pharmaceutical industry. Currently, antibody candidates are exhaustively tested one- by- one in animal models to determine pharmacokinetic and pharmacodynamic (PK/PD) profiles. The simultaneous analysis of antibody mixtures in single animals, called cassette- dosing, could in principle overcome this bottlen...
• Machine learning active-nematic hydrodynamics (vol 118, e2016708118, 2021) AI翻译
  作者：Colen, Jonathan; Han, Ming; Zhang, Rui; Redford, Steven A.; Lemma, Linnea M.; Morgan, Link; Ruijgrok, Paul, V; Adkins, Raymond; Bryant, Zev; Dogic, Zvonimir; Gardel, Margaret L.; de Pablo, Juan J.; Vitelli, Vincenzo
• Cryo- EM structures reveal the acetylation process of piccolo NuA4 AI翻译
  作者：Wang, Lin; Zhang, Haonan; Jia, Qi; Li, Wenyan; Yang, Chenguang; Ma, Lijuan; Li, Ming; Lu, Ying; Zhu, Hongtao; Zhu, Ping
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation the histones H2A, H2A.Z, and H4, thereby affecting gene transcription. However, the acetylation process of NuA4, such as how NuA4 acetylates H4 and H2A.Z differently, remains largely elusive. Here, using cryoelectron microscopy (cryo-EM) single particle analysis, we present seven cryo-EM structures of piccolo NuA4 (pNuA4) in complex with wild-type H2A.Z or H2A.Z-mutant-containing nucleosomes in the absence ...