12期

最新文章

• ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase AI翻译
  作者：Kumari, Anni; Larsen, Sanne W. R.; Bondesen, Signe; Qian, Yuewei; Tian, Hao D.; Walker, Sydney G.; Davies, Brandon S. J.; Remaley, Alan T.; Young, Stephen G.; Konrad, Robert J.; Jorgensen, Thomas J. D.; Ploug, Michael
  作者单位：Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; University of Copenhagen; University of Southern Denmark; Eli Lilly; Lilly Research Laboratories; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Iowa; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA
  摘要：Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by the angiopoietin-like proteins (ANGPTL3, ANGPTL4, ANGPTL8), which control the delivery of TRL-derived lipid nutrients to tissues in a temporal and spatial fashion. This regulation of LPL mediates the partitioning of lipid delivery to adipose tissue and striated muscle according to nutritional status. A complex between ANGPT...
• Agriculture's impact on water-energy balance varies across climates AI翻译
  作者：Zaerpour, Masoud; Hatami, Shadi; Papalexiou, Simon Michael; Pietroniro, Alain; Nazemi, Ali
  作者单位：University of Calgary; Universidade de Sao Paulo; Czech University of Life Sciences Prague; Concordia University - Canada
  摘要：Agriculture is a cornerstone of global food production, accounting for a substantial portion of water withdrawals worldwide. As the world's population grows, so does the demand for water in agriculture, leading to alterations in regional water-energy balances. We present an approach to identify the influence of agriculture on the water-energy balance using empirical data. We explore the departure from the Budyko curve for catchments with agricultural expansion and their associations with chang...
• Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells AI翻译
  作者：Chen, Li- Jing; Li, Julie Yi- Shuan; Nguyen, Phu; Norwich, Gerard; Wang, Yingxiao; Teng, Dayu; Shiu, Yan- Ting; Shyy, John Y. J.; Chien, Shu
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of Southern California; Utah System of Higher Education; University of Utah; US Department of Veterans Affairs; Utah System of Higher Education; Veterans Health Administration (VHA); University of Utah; Utah System of Higher Education; University of Utah; University of California System; University of California San Diego
  摘要：Endothelial cells (ECs) are constantly exposed to hemodynamic forces, which play a crucial role in regulating EC functions. Pulsatile laminar shear stress (PS), representing atheroprotective flow, maintains the anti-inflammation and homeostatic phenotype of ECs, but the comprehensive mechanism underlying the PS-repression of inflammatory genes remains to be determined. In this study, we investigated the role of chromatin organization in mediating the effects of PS on inflammatory gene expressi...
• Reinforcement learning-based adaptive strategies for climate change adaptation: An application for coastal flood risk management AI翻译
  作者：Feng, Kairui; Lin, Ning; Kopp, Robert E.; Xian, Siyuan; Oppenheimer, Michael
  作者单位：Tongji University; Princeton University; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Princeton University; Princeton University; Princeton University
  摘要：Conventional computational models of climate adaptation frameworks inadequately consider decision-makers' capacity to learn, update, and improve decisions. Here, we investigate the potential of reinforcement learning (RL), a machine learning technique that efficaciously acquires knowledge from the environment and systematically optimizes dynamic decisions, in modeling and informing adaptive climate decision-making. We consider coastal flood risk mitigations for Manhattan, New York City, USA (N...
• The Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and yield in rice AI翻译
  作者：Huang, Luojiang; Fang, Na; Zhang, Limin; Xu, Ran; Zhang, Baolan; Duan, Penggen; Li, Guansong; Luo, Yuehua; Li, Yunhai
  作者单位：Hainan University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Genetics & Developmental Biology, CAS; Inner Mongolia University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Seed size is one of the important yield traits, and size control is also a fundamental developmental question. The knowledge about the genetic and molecular mechanisms that govern seed size is crucial for improving crop yield. Here, we report that the Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and weight in rice. Loss of function of OsMED23 or OsJMJ703 causes narrow and light grains, while overexpression ...
• Hardware-optimal quantum algorithms AI翻译
  作者：Muroya, Stefanie; Chatterjee, Krishnendu; Henzinger, Thomas A.
  作者单位：Institute of Science & Technology - Austria
  摘要：Quantum hardware is inherently fragile and noisy. We find that the accuracy of traditional quantum error correction algorithms can be improved depending on the hardware. Given different hardware specifications, we automatically synthesize hardware-optimal algorithms for parity correction, qubit resetting, and GHZ (Greenberger-Horne-Zeilinger) state preparation. Using stochastic techniques from computer science, our method presents a computational tool to compute exact accuracy guarantees and s...
• Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission AI翻译
  作者：Pang, Xiaoyun; Zhang, Yan; Park, Kunyou; Liao, Zhenyu; Li, Jian; Xu, Jiashu; Hong, Minh-Triet; Yin, Guoliang; Zhang, Tongming; Wang, Yaoyu; Egelman, Edward H.; Fan, Jun; Hsu, Victor W.; Park, Seung-Yeol; Sun, Fei
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Pohang University of Science & Technology (POSTECH); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; City University of Hong Kong; City University of Hong Kong; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Virginia (UVA) Health System; University of Virginia; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS
  摘要：ADP- Ribosylation Factor (ARF) small GTPases have been found to act in vesicle fission through a direct ability to tubulate membrane. We have pursued cryoelectron microscopy (EM) to reveal at 3.9 & Aring; resolution how ARF6 assembles into a protein lattice on tubulated membrane. Molecular dynamics simulation studies confirm and extend the cryo- EM findings. The ARF6 lattice exhibits features that are distinct from those formed by other membrane- bending proteins. We identify protein contacts ...
• A splendid molecular factory: De-and reconstruction of the mammalian respiratory chain AI翻译
  作者：Rimle, Lukas; Phillips, Ben P.; Barra, Isabela M. Codo Costa; Arnold, Noelle; Hennebert, Charlie; Meier, Thomas; von Ballmoos, Christoph
  作者单位：University of Bern; Imperial College London; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Mitochondrial respiratory complexes I to IV and the F1Fo-ATP synthase (complex V) are large protein assemblies producing the universal cellular energy currency adenosine triphosphate (ATP). Individual complexes have been extensively studied in vitro, but functional co-reconstitution of several mammalian complexes into proteoliposomes, in particular, the combination of a primary pump with the ATP synthase, is less well understood. Here, we present a generic and scalable strategy to purify mamma...
• Polymorphic transposable elements contribute to variation in recombination landscapes AI翻译
  作者：Huang, Yuheng; Gao, Zita Y.; Ly, Kayla; Lin, Leila; Lambooij, Jan Paul; King, Elizabeth G.; Janssen, Aniek; Wei, Kevin H. -C.; Lee, Yuh Chwen G.
  作者单位：University of California System; University of California Irvine; Utrecht University; Utrecht University Medical Center; University of Missouri System; University of Missouri Columbia; University of British Columbia
  摘要：Meiotic recombination is a prominent force shaping genome evolution, and understanding why recombination rates vary within and between species has remained a central, though challenging, question. Variation in recombination is widely thought to influence the efficacy of selection in purging transposable elements (TEs), prevalent selfish genetic elements, leading to widely observed negative correlations between TE abundance and recombination rates across taxa. However, accumulating evidence sug...
• Coarse-graining bacterial diffusion in disordered media to surface states AI翻译
  作者：Mattingly, Henry H.
  作者单位：Simons Foundation; Flatiron Institute
  摘要：Bacterial motility in spatially structured environments impacts a variety of natural and engineering processes. Constructing models to predict, control, and design bacterial motility for these processes remains challenging because bacteria and active swimmers have complex interactions with surfaces and because the precise environment geometry is unknown. Here, we present a method for deriving bacterial diffusion coefficients in disordered media in terms of cell and environmental parameters. Th...