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作者：Kaul, Sunil; Cole, Nelson B.; Bandola-Simon, Joanna; Lu, Ying; Tondini, Elena; Walseng, Even; Roche, Paul A.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); AstraZeneca
摘要：MHC class II glycoproteins (MHC-II) bind peptides derived from exogenous antigens and dendritic cells (DCs) present these peptide MHC-II (pMHC-II) complexes to antigen-specific CD4 T cells during immune responses. The turnover of surface pMHC-II on antigen-presenting cells (APCs) is controlled by ubiquitin-mediated degradation of pMHC-II by the E3 ubiquitin ligase March-I. To study March-I protein expression, we have generated a mouse in which a V5 epitope-tag was knocked-in to the endogenous ...
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作者：Gustavson, Daniel E.; Borriello, Giulia A.; Karhadkar, Mohini A.; Rhee, Soo Hyun; Corley, Robin P.; Rhea, Sally-Ann; DiLalla, Lisabeth F.; Wadsworth, Sally J.; Friedman, Naomi P.; Reynolds, Chandra A.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; Southern Illinois University System; Southern Illinois University
摘要：Measures of general cognitive ability (GCA) are highly stable from adolescence onward, particularly at the level of genetic influences. In contrast, measurement of GCA in early life (before 3 y old) is less reliable and less is known about the stability of GCA across this period, including its relation to adult GCA. Using data from the Colorado Longitudinal Twin study (N = 1,098), we examined the stability of GCA measures across 5 time-points (years 1 to 2, 3, 7, 16, and 29), including how an ...
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作者：Chen, Wenqiang; Liu, Xiangyu; Munoz, Vitor Rosetto; Kahn, C. Ronald
作者单位：Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical School; Harvard University; Harvard Medical School; Steno Diabetes Center; Universidade Estadual de Campinas
摘要：Insulin receptors are present on cells throughout the body, including the brain. Dysregulation of insulin signaling in neurons and astrocytes has been implicated in altered mood, cognition, and the pathogenesis of Alzheimer's disease (AD). To define the role of insulin signaling in microglia, the primary phagocytes in the brain critical for maintenance and damage repair, we created mice with an inducible microglia-specific insulin receptor knockout (MG-IRKO). RiboTag profiling of microglial mR...
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作者：Townrow, Luke A.; Krupenye, Christopher
作者单位：Johns Hopkins University
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作者：Fueller, David; Sasko, Benjamin; Ritter, Oliver
作者单位：St. Marien Hospital; Ruhr University Bochum
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作者：Fan, Chengcheng; Keeffe, Jennifer R.; Malecek, Kathryn E.; Cohen, Alexander A.; West Jr, Anthony P.; Baharani, Viren A.; Rorick, Annie, V; Gao, Han; Gnanapragasam, Priyanthi N. P.; Rho, Semi; Alvarez, Jaasiel; Segovia, Luisa N.; Hatziioannou, Theodora; Bieniasz, Paul D.; Bjorkman, Pamela J.
作者单位：California Institute of Technology; Rockefeller University; Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Broad immune responses are needed to mitigate viral evolution and escape. To induce antibodies against conserved receptor-binding domain (RBD) regions of SARS-like betacoronavirus (sarbecovirus) spike proteins that recognize SARS-CoV-2 variants of concern and zoonotic sarbecoviruses, we developed mosaic-8b RBD nanoparticles presenting eight sarbecovirus RBDs arranged randomly on a 60-mer nanoparticle. Mosaic-8b immunizations protected animals from challenges from viruses whose RBDs were matche...
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作者：Gozashti, Landen; Nakamoto, Anne; Russell, Shelbi; Corbett-Detig, Russell
作者单位：Harvard University; Harvard University; Harvard University; Howard Hughes Medical Institute; Harvard Medical School; University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz
摘要：Since the discovery of spliceosomal introns in eukaryotic genomes, the proximate molecular and evolutionary processes that generate new introns have remained a critical mystery. Specialized transposable elements (TEs), introners, are thought to be one of the major drivers of intron gain in diverse eukaryotes. However, the molecular mechanism(s) and evolutionary processes driving introner propagation within and between lineages remain elusive. Here, we analyze 8,716 genomes, revealing 1,093 int...
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作者：Tatsukawa, Tsuyoshi; Teramae, Jun-nosuke
作者单位：Kyoto University
摘要：A recent study has suggested that the stimulus responses of cortical neural populations follow a critical power law. More precisely, the power spectrum of the covariance matrix of neural responses follows a power law with an exponent indicating that the neural manifold lies on the edge of differentiability. This criticality is hypothesized to balance expressivity and robustness in neural encoding, as population responses on a nondifferential fractal manifold are thought to be overly sensitive ...
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作者：Sheneman, Lucas; Balogun, Sulaimon; Johnson, Jill L.; Harrison, Maria J.; Vasdekis, Andreas E.
作者单位：University of Idaho; University of Idaho; University of Idaho; Cornell University; Boyce Thompson Institute for Plant Research; United States Department of Energy (DOE); Pacific Northwest National Laboratory
摘要：Enhancing the reliability and reproducibility of optical microscopy by reducing specimen irradiance continues to be an important biotechnology target. As irradiance levels are reduced, however, the particle nature of light is heightened, giving rise to Poisson noise, or photon sparsity that restricts only a few (0.5%) image pixels to comprise a photon. Photon sparsity can be addressed by collecting approximately 200 photons per pixel; this, however, requires long acquisitions and, as such, sub...
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作者：Tauzin, Tibor
作者单位：University of Vienna; University of Vienna
