21期

最新文章

• CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation AI翻译
  作者：Kaul, Sunil; Cole, Nelson B.; Bandola-Simon, Joanna; Lu, Ying; Tondini, Elena; Walseng, Even; Roche, Paul A.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); AstraZeneca
  摘要：MHC class II glycoproteins (MHC-II) bind peptides derived from exogenous antigens and dendritic cells (DCs) present these peptide MHC-II (pMHC-II) complexes to antigen-specific CD4 T cells during immune responses. The turnover of surface pMHC-II on antigen-presenting cells (APCs) is controlled by ubiquitin-mediated degradation of pMHC-II by the E3 ubiquitin ligase March-I. To study March-I protein expression, we have generated a mouse in which a V5 epitope-tag was knocked-in to the endogenous ...
• Stability of general cognitive ability from infancy to adulthood: A combined twin and genomic investigation AI翻译
  作者：Gustavson, Daniel E.; Borriello, Giulia A.; Karhadkar, Mohini A.; Rhee, Soo Hyun; Corley, Robin P.; Rhea, Sally-Ann; DiLalla, Lisabeth F.; Wadsworth, Sally J.; Friedman, Naomi P.; Reynolds, Chandra A.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; Southern Illinois University System; Southern Illinois University
  摘要：Measures of general cognitive ability (GCA) are highly stable from adolescence onward, particularly at the level of genetic influences. In contrast, measurement of GCA in early life (before 3 y old) is less reliable and less is known about the stability of GCA across this period, including its relation to adult GCA. Using data from the Colorado Longitudinal Twin study (N = 1,098), we examined the stability of GCA measures across 5 time-points (years 1 to 2, 3, 7, 16, and 29), including how an ...
• Loss of insulin signaling in microglia impairs cellular uptake of Aβ and neuroinflammatory response exacerbating AD- like neuropathology AI翻译
  作者：Chen, Wenqiang; Liu, Xiangyu; Munoz, Vitor Rosetto; Kahn, C. Ronald
  作者单位：Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical School; Harvard University; Harvard Medical School; Steno Diabetes Center; Universidade Estadual de Campinas
  摘要：Insulin receptors are present on cells throughout the body, including the brain. Dysregulation of insulin signaling in neurons and astrocytes has been implicated in altered mood, cognition, and the pathogenesis of Alzheimer's disease (AD). To define the role of insulin signaling in microglia, the primary phagocytes in the brain critical for maintenance and damage repair, we created mice with an inducible microglia-specific insulin receptor knockout (MG-IRKO). RiboTag profiling of microglial mR...
• Reply to Tauzin: How to implement novelty in theory of mind tasks AI翻译
  作者：Townrow, Luke A.; Krupenye, Christopher
  作者单位：Johns Hopkins University
• Genetic associations with socioeconomic status are limited in explaining the socioeconomic health gradient AI翻译
  作者：Fueller, David; Sasko, Benjamin; Ritter, Oliver
  作者单位：St. Marien Hospital; Ruhr University Bochum