21期

最新文章

• HCK regulates NLRP12-mediated PANoptosis AI翻译
  作者：Nadendla, Eswar Kumar; Alluri, Priyanshu; Sundaram, Balamurugan; Kumar, Sivakumar Prasanth; Chadchan, Sangappa B.; Sarkar, Roman; Kanneganti, Thirumala - Devi
  作者单位：St Jude Children's Research Hospital
  摘要：NOD-like receptors (NLRs) are a highly conserved family of cytosolic pattern recognition receptors that drive innate immune responses against pathogens, pathogen-associated molecular patterns, damage-associated molecular patterns, and homeostatic disruptions. Within the NLR family, NLRP12 was recently identified as a key regulator of PANoptosis, which is an innate immune, lytic cell death pathway initiated by innate immune sensors and driven by caspases and RIPKs through PANoptosome complexes....
• The white lupin CCR1 receptor- like kinase controls systemic Autoregulation of Cluster Root and Nodule Development AI翻译
  作者：Marques, Laurence; Divol, Fanchon; Boultif, Alexandra; Garcia, Fanny; Soriano, Alexandre; Maurines- Carboneill, Clea; Fernandez, Virginia; Verstraeten, Inge; Pidon, Helene; Izquierdo, Esther; Hufnagel, Barbara; Peret, Benjamin
  作者单位：Ghent University; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut Agro; INRAE
  摘要：Root development is tightly regulated in plants to optimize nutrient acquisition and interactions with soil microorganisms. In legumes, the Autoregulation of Nodulation (AoN) pathway systemically controls the proliferation of root nodules, which are energy-intensive organs. Mutations affecting the AoN pathway result in a hypernodulation phenotype accompanied by altered root development. However, it remains unclear whether this modification of root development is also systemic and coordinated w...
• Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments (vol 121, e2404555121, 2024) AI翻译
  作者：Garaizar, Adiran; Diaz-Oviedo, David; Zablowsky, Nina; Rissanen, Sami; Kobberling, Johannes; Sun, Jiawei; Steiger, Christoph; Steigemann, Patrick; Mann, Florian A.; Meier, Katharina
• Induction of the ISR by AB5 subtilase cytotoxin drives type- I IFN expression in pDCs via STING activation AI翻译
  作者：Barros, Daniela; Ferreira, Beatriz H.; Garcia-Gonzalez, Paulina; Carbone, Francesco; Luka, Marine; Leite-Pinheiro, Fatima; Machado, Mariana D.; Nikolaou, Theopisti; Pilotti, Angelo; Goguet, Eliot; Antas, Paulo; Mendes, Andreia; Zhang, Lichen; Cresci, Marina; Galliot, Lou; Gigan, Julien P.; Reverendo, Marisa; Su, Bing; Narita, Miwako; Paton, Adrienne W.; Paton, James C.; Rocchi, Stephane; Rieux-Laucat, Frederic; Arguello, Rafael J.; Nal, Beatrice; Liang, Yinming; Menager, Mickael; Gatti, Evelina; Almeida, Catarina R.; Pierre, Philippe
  作者单位：Universidade de Aveiro; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Universidade de Aveiro; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Henan Medical University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Niigata University; University of Adelaide; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a proinflammatory response across distinct cell subsets. Notably, SubAB selectively induces type-I interferon (IFN) expression in plasmacytoid dendritic cells, acting synergistically with Toll-like receptor 7 stimulation. The induction of type-I IFN in response to SubAB relies on stimulator of interferon genes (STING) acti...
• Where do fish go and why? For many species, nobody knows AI翻译
  作者：McDermott, Amy
• Arteries are finely tuned thermosensors regulating myogenic tone and blood flow AI翻译
  作者：Phan, Thieu X.; Sahibzada, Niaz; Freichel, Marc; Miyares, Rosa L.; Ahern, Gerard P.
  作者单位：Georgetown University; Vinh University; Ruprecht Karls University Heidelberg
  摘要：In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure. Here, we reveal that tissue temperature, combined with intraluminal pressure, critically determines myogenic tone. Heating steeply activates tone in skeletal muscle, gut, brain, and skin arteries with temperature coefficients (Q(10)) of similar to 11 to 20. Each of these tissues has a distinct r...
• Flamingos use their L-shaped beak and morphing feet to induce vortical traps for prey capture AI翻译
  作者：Jimenez, Victor M. Ortega -; Yee, Tien; Rohilla, Pankaj; Seleb, Benjamin; Belair, Jake; Bhamla, Saad
  作者单位：University of California System; University of California Berkeley; University of Maine System; University of Maine Orono; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Kennesaw State University; University System of Georgia; Georgia Institute of Technology
  摘要：Flamingos feature one of the most sophisticated filter-feeding systems among birds, characterized by upside-down feeding, comb-like lamellae, and a piston-like tongue. However, the hydrodynamic functions of their L-shaped chattering beak, S-curved neck, and distinct behaviors such as stomping and feeding against the flow remain a mystery. Combining live flamingo experiments with live brine shrimp and passive particles, bioinspired physical models, and 3D CFD simulations, we show that flamingos...
• The evolution of thermal performance curves in response to rising temperatures across the model genus yeast AI翻译
  作者：Molinet, Jennifer; Stelkens, Rike
  作者单位：Stockholm University
  摘要：The maintenance of biodiversity crucially depends on the evolutionary potential of populations to adapt to environmental change. Accelerating climate change and extreme temperature events urge us to better understand and forecast evolutionary responses. Here, we harnessed the power of experimental evolution with the microbial model system yeast (Saccharomyces spp.) to measure the evolutionary potential of populations to adapt to future warming, in real- time and across the entire phylogenetic ...
• Autophagy- mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection AI翻译
  作者：Yu, Jingyou; Zheng, Yi-Min; Sheridan, Megan A.; Li, Pei; Ezashi, Toshihiko; Roberts, R. Michael; Liu, Shan-Lu
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; State Key Laboratory of Respiratory Disease; Guangzhou Medical University; Guangzhou Laboratory; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Zika virus (ZIKV) infection can lead to a variety of clinical outcomes, including severe congenital abnormalities. The phosphatidylserine receptors AXL and TIM-1 are recognized as critical entry factors for ZIKV in vitro. However, it remains unclear whether and how ZIKV regulates these receptors during infection. In this study, we investigated AXL and TIM-1 expression in human lung adenocarcinoma epithelial A549 cells, glioblastoma U87 cells, and embryonic stem cell-derived trophoblasts follow...
• Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer AI翻译
  作者：Wang, Hong; Huang, Jie; Zhang, Zhenhua; An, Yana; Sun, Huizi; Chen, Jianghe; Feng, Weineng; Duan, Hao; Mou, Yonggao; Wang, Yuanxiang; Liu, Peiqing; Zhou, Huihao; Chen, Hong - Wu; Zhang, Jian; Lu, Xiaoyun; Wang, Junjian
  作者单位：Sun Yat Sen University; Guangdong Academy of Medical Sciences & Guangdong General Hospital; Southern Medical University - China; Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; University of California System; University of California Davis; Sun Yat Sen University; Jinan University
  摘要：Small-cell lung cancer (SCLC) is the most lethal type of lung cancer, characterized by rapid evolution from chemosensitivity to chemoresistance and limited treatment options. However, the mechanisms underlying this evolution remain poorly understood. Here, we show that Retinoid X receptor gamma (RXR gamma) is uniquely overexpressed in chemo-resistant SCLC tumors, and that RXR gamma serves as an essential factor driving chemoresistance in SCLC. RXR gamma forms phase-separated droplets with LSD1...