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作者：Hui, Chenggong; de Vries, Reinier; Kopec, Wojciech; de Groot, Bert L.
作者单位：University of London; Queen Mary University London
摘要：Potassium (K+) channels are widely distributed in many types of organisms. They combine high efficiency (similar to 100 pS) and K+/Na+ selectivity by a conserved selectivity filter (SF). Molecular Dynamics (MD) simulations can provide detailed, atomistic mechanisms of this sophisticated ion permeation. However, currently there are clear inconsistencies between computational predictions and experimental results. First, the ion occupancy of the SF in simulations is lower than expected (similar t...
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作者：Luk, Tsz-Yat; Yim, Lok-Yan; Zhou, Runhong; Mo, Yufei; Huang, Huarong; Zhao, Meiqing; Dai, Jie; Lau, Thomas Tsz-Kan; Huang, Xiner; Lui, Grace Chung-Yan; Yuen, Kwok-Yung; Chan, Jasper Fuk-Woo; Cheng, Alfred Sze-Lok; Chen, Zhiwei; Chu, Hin
作者单位：University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; University of Hong Kong
摘要：A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The Shock & Kill strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs, followed by elimination of infected cells. However, current LRAs are insufficient in fully reactivating the latent reservoirs. Therefore, investigation on novel HIV-1 latency regulators will be crucial to the success of HIV-1 cure research. Here, we...
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作者：Eggertsen, Taylor G.; Travers, Joshua G.; Hardy, Elizabeth J.; Wolf, Matthew J.; Mckinsey, Timothy A.; Saucerman, Jeffrey J.
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作者：Lu, Hongliang; Zhu, Meixin; Lu, Chao; Feng, Shuo; Wang, Xuesong; Wang, Yinhai; Yang, Hai
作者单位：Hong Kong University of Science & Technology (Guangzhou); Hong Kong University of Science & Technology; Southeast University - China; Beijing Institute of Technology; Tsinghua University; Tongji University; University of Washington; University of Washington Seattle
摘要：Autonomous vehicles (AVs) will soon cruise our roads as a global undertaking. Beyond completing driving tasks, AVs are expected to incorporate ethical considerations into their operation. However, a critical challenge remains. When multiple road users are involved, their impacts on AV ethical decision-making are distinct yet interrelated. Current AVs lack social sensitivity in ethical decisions, failing to enable both differentiated consideration of road users and a holistic view of their coll...
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作者：Nguyen, Rita H.; Newton, Michelle; Kratofil, Rachel M.; Scott, Brittney N. V.; Castanheira, Fernanda; Kim, Jung- seok; Ginhoux, Florent; Jung, Steffen; Kubes, Paul
作者单位：University of Calgary; Weizmann Institute of Science; Chinese Academy of Sciences; Shanghai Jiao Tong University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); UNICANCER; Gustave Roussy
摘要：Concussions can cause debilitating symptoms despite no evidence of structural changes on diagnostic imaging. The cellular events occurring in the brain parenchyma following concussion, especially repetitive concussion, are not well elucidated. We developed a concussion model to induce a confined area of injury without causing frank hemorrhage. Using intravital microscopy, we observe activation of the vasculature that supported neutrophil rolling and platelet adhesion but no overt cellular recr...
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作者：Wang, Xiao; Tsien, Sophia J.; Jin, Min; Goldberg, Michael E.; Zhang, Mingsha; Qian, Ning
作者单位：Beijing Normal University; Columbia University; Columbia University; Columbia University; Columbia University; Columbia University; Columbia University
摘要：We perceive a stable, continuous world despite drastic changes of retinal images across saccades. However, while persistent objects in daily life appear stable across saccades, stimuli flashed around saccades can be grossly mislocalized. We address this puzzle with our recently proposed circuit model for perisaccadic receptive-field (RF) remapping in the lateral interparietal area (LIP) and frontal eye fields (FEF). The model uses center-excitation/surround-inhibition connections to store a re...
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作者：Gravendyck, Julia; Riding, James B.; Coimbra, Rute; Heimhofer, Ulrich
作者单位：Leibniz University Hannover; University of Bonn; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Universidade de Aveiro
摘要：New evidence on the timing of early angiosperm evolution is presented through the discovery of four well-dated tricolpate pollen grains from the Early Cretaceous midlatitudes. Recovered from nearshore marine sediments in the Lusitanian Basin of Portugal, these fossils significantly expand the pre-Aptian tricolpate pollen record and document a greater number of pre-Aptian tricolpate grains in the midlatitudes than previously recognized. The fossil evidence was obtained through the innovative ap...
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作者：Ford, Jonathan J.; Aberturas, Javier Santos -; Hems, Edward S.; Sallmen, Joseph W.; Bogeholz, Lena A. K.; Polturak, Guy; Osbourn, Anne; Wright, Joseph A.; V. Rodnina, Marina; Vereecke, Danny; Francis, Isolde M.; Truman, Andrew W.
作者单位：Hebrew University of Jerusalem; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of East Anglia; HOWEST University of Applied Sciences; California State University System; California State University Bakersfield
摘要：The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confers their metalloproteinase inhibitory activity. Actinonin is the most potent natural inhibitor of peptide deformylase (PDF) and exerts antimicrobial and herbicidal bioactivity by disrupting protein synthesis. Here, we used a genomics-led approach to identify candidate biosynthetic gene clusters (BGCs) hypothesized to produce HPS-containing natural p...
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作者：Xie, Wanlin; Sun, Weidi; Li, Qin; Dang, Yang; Ma, Lele; Liu, Yuan; Zhang, Hui; Qu, Fengli; Tan, Weihong
作者单位：Tianjin University; Zhejiang Cancer Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
摘要：Cell-membrane proteins are critical mediators of signal transduction, playing essential roles in disease occurrence and progression. The emerging LYTACs (Lysosome-targeting chimeras) technology combines drug-targeting strategies with lysosomal degradation, providing a novel approach to drug development and offering new possibilities for disease therapy. However, the clinical applicability of current LYTAC degraders is limited by the variable expression of lysosome-targeting receptors (LTRs) in...
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作者：Wu, Xin-Rui; Yang, Liu; Wu, Bang-Sheng; Cheng, Wei; Yu, Jin-Tai
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
