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作者：Vidal, Mayra C.; Liu, Cong; Wang, Shengpei; Segraves, Kari A.
作者单位：University of Massachusetts System; University of Massachusetts Boston; Harvard University; Syracuse University; National Science Foundation (NSF)
摘要：Coevolution is a ubiquitous driver of diversification in both mutualistic and antagonistic interactions between species. In mutualisms, coevolution can result in trait complementarity between partners that facilitates their persistence. Despite its importance, most of what we know about coevolution in mutualism comes from obligate interactions, whereas we know comparatively little about facultative interactions, arguably the most common type of mutualism. To evaluate coevolutionary dynamics in...
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作者：Mandelboim, Ofer; Porgador, Angel
作者单位：Hebrew University of Jerusalem; Ben-Gurion University of the Negev
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作者：Banuelos, Allison; Baez, Michelle; Zhang, Allison; Yilmaz, Leyla; Kasberg, William; Volk, Regan; Georgeos, Nardin; Sedova, Elle Koren -; Le, Uyen; Burden, Andrew T.; Marjon, Kristopher D.; Schwartz, Jennifer Lippincott -; Zaro, Balyn W.; Weissman, Irving L.
作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; University of California System; University of California San Francisco; Stanford University
摘要：Calreticulin (CALR) is primarily an endoplasmic reticulum chaperone protein that also plays a key role in facilitating programmed cell removal (PrCR) by acting as an eat-me signal for macrophages, directing their recognition and engulfment of dying, diseased, or unwanted cells. Recent findings have demonstrated that macrophages can transfer their own CALR onto exposed asialoglycans on target cells, marking them for PrCR. Despite the critical role CALR plays in this process, the molecular mecha...
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作者：Martis, Stephen; Schwab, David J.; Grandpre, Trevor
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Princeton University; City University of New York (CUNY) System; Princeton University; Princeton University
摘要：In large, natural ecosystems, many (>= 1) phenotypically relevant mutants can emerge over the characteristic turnover time of the population. When this is the case, there can be `eco-evolutionary feedback' between the dynamical processes that underlie mutation, selection and ecology. We show that, owing to such feedback, the precise details of the mutational process can have a qualitative impact on the long-term behavior of an eco-evolutionary system, in contrast to the classical population ge...
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作者：Kelso, Lauren E.; Dobolyi, David G.; Grabman, Jesse H.; Dodson, Chad S.
作者单位：University of Virginia; University of Colorado System; University of Colorado Boulder; New Mexico State University
摘要：Mistaken eyewitness identification is one of the leading causes of false convictions. Improving law enforcement's ability to identify correct identifications could have profound implications for criminal justice. Across two experiments, we show that AI-assistance can improve people's ability to distinguish between accurate and inaccurate eyewitness lineup identifications. Participants (Experiment 1: N = 1,092, Experiment 2: N = 1,809) saw an eyewitness's lineup identification, accompanied by t...
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作者：Castelnovo, Claudio
作者单位：University of Cambridge
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作者：Chen, Qingyi; An, Sanqi; Wang, Chuanlong; Zhou, Yanshuang; Liu, Xingguo; Ren, Wenkai
作者单位：Guangxi Medical University; South China Agricultural University; Guangxi Medical University; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Guangzhou Medical University; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Guangzhou Medical University
摘要：Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. Traditionally, phase separation directly regulates cell functions by driving RNA, proteins, or other molecules to concentrate into lipid droplets. Recent studies show that phase separation regulates cell functions and diseases through the regulation of subcellular organelles, particularly mitochondria. In fact, phase separation is involved in various mitochondrial activities incl...
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作者：Paries, Michael; Hobecker, Karen; Luelmo, Sofia Hernandez; Binci, Filippo; Guercio, Angelica; Uslaender, Annika; Cardoso, Catarina; Si, Yang; Wankner, Lotta; Bashyal, Sagar; Troycke, Philip; Brueckner, Franziska; Pimprikar, Priya; Shabek, Nitzan; Gutjahr, Caroline
作者单位：Technical University of Munich; Max Planck Society; University of California System; University of California Davis; University of Munich; University of Padua; University of Freiburg; University of California System; University of California San Diego; Salk Institute
摘要：During arbuscular mycorrhiza (AM) symbiosis AM fungi form tree-shaped structures called arbuscules in root cortex cells of host plants. Arbuscules and their host cells are central for reciprocal nutrient exchange between the symbionts. REQUIRED FOR ARBUSCULAR MYCORRHIZATION1 (RAM1) encodes a GRAS protein crucial for transcriptionally regulating plant genes needed for arbuscule development and nutrient exchange. Similar to other GRAS proteins, RAM1 likely does not bind to DNA and how RAM1 activ...
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作者：Gunter, Christopher C.; Treadwell, Danielle D.; Resende Jr, Marcio F. R.; Whitaker, Vance M.; Balmant, Kelly M.; Shelnutt, Karla P.; Borum, Peggy R.; Andrade, Juan E.; Goodrich-Schneider, Renee; Bernier, Angelina, V; Donahoo, William T.; Jaffee, Michael S.; Angle, J. Scott; Hanson, Andrew D.
作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：It is clear that the escalating epidemic of insulin resistance and type 2 diabetes has reached a crisis level in the United States, that overweight and obesity are drivers, and that diets and the food system have major roles. It is also clear that nutrition and medical research point to increased healthful fruit and vegetable intake as a key part of any strategy to manage the crisis. But although increasing healthful intake entails both expanding production of fruits and vegetables and improvi...
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作者：Copos, Calina; Sun, Yao-Hui; Zhu, Kan; Zhang, Yan; Reid, Brian; Draper, Bruce; Lin, Francis; Yue, Haicen; Bernadskaya, Yelena; Zhao, Min; Mogilner, Alex
作者单位：Northeastern University; Northeastern University; University of California System; University of California Davis; University of California System; University of California Davis; Hangzhou Normal University; University of California System; University of California Davis; University of Manitoba; University of Vermont; New York University; New York University
摘要：Motile cells migrate directionally in the electric field (EF) in a process known as galvanotaxis, an important phenomenon in wound healing and development. We previously reported that individual fish keratocyte cells migrate to the cathode in EFs, that inhibition of PI3 kinase (PI3K) reverses single cells to the anode, and that large cohesive groups of either unperturbed or PI3K-inhibited cells migrate to the cathode. Here, we report that small uninhibited cell groups move to the cathode, whil...
