21期

最新文章

• The cortical critical power law balances energy and information in an optimal fashion AI翻译
  作者：Tatsukawa, Tsuyoshi; Teramae, Jun-nosuke
  作者单位：Kyoto University
  摘要：A recent study has suggested that the stimulus responses of cortical neural populations follow a critical power law. More precisely, the power spectrum of the covariance matrix of neural responses follows a power law with an exponent indicating that the neural manifold lies on the edge of differentiability. This criticality is hypothesized to balance expressivity and robustness in neural encoding, as population responses on a nondifferential fractal manifold are thought to be overly sensitive ...
• Physical activity stimulates clock neurons of the day-active rodent Arvicanthis ansorgei AI翻译
  作者：Caputo, Rosanna; Schoonderwoerd, Robin A.; Ramkisoensing, Ashna; Janse, Jan A. M.; van Diepen, Hester C.; Raison, Sylvie; Pevet, Paul; Sage-Ciocca, Dominique; Deboer, Tom; Challet, Etienne; Meijer, Johanna H.
  作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
  摘要：Our biological clock, located in the suprachiasmatic nucleus (SCN), controls behavioral activity rhythms by producing circadian rhythms in SCN electrical activity. Behavioral studies in humans suggest that the clock is sensitive not only to light but also to physical activity. Here, we examined the effect of physical activity on the brain's clock in the diurnal rodent, Arvicanthis ansorgei. We found that the electrical activity of SCN neurons in vitro is high during the day and low during the ...
• Multiparametric functional characterization of individual lipid nanoparticles using surface- sensitive light- scattering microscopy AI翻译
  作者：Sjoeberg, Mattias; Olsen, Erik; Mapar, Mokhtar; Parkkila, Petteri; Niederkofler, Simon; Mohammadi, Sara; Jing, Yujia; Emilsson, Gustav; Lindfors, Lennart; Agnarsson, Bjorn; Hook, Fredrik
  作者单位：Chalmers University of Technology; AstraZeneca
  摘要：The most efficient lipid nanoparticles (LNPs) for gene therapeutics rely on specific lipids that protect the oligonucleotide cargo and aid cellular uptake and subsequent endosomal escape. Yet, the efficacy of current state-of-the-art LNP formulations remains low, a few percent at best. A deeper understanding of how LNP cargo, lipid composition, stoichiometry, size, structure, and pH-induced conformational changes influence their efficiency is therefore necessary for improved design. Given the ...
• Engineering spin coherence in core-shell diamond nanocrystals AI翻译
  作者：Zvi, Uri; Candido, Denis R.; Weiss, Adam M.; Jones, Aidan R.; Chen, Lingjie; Golovina, Iryna; Yu, Xiaofei; Wang, Stella; Talapin, Dmitri V.; Flatte, Michael E.; Esser, Aaron P.; Maurer, Peter C.
  作者单位：University of Chicago; University of Iowa; University of Chicago; University of Chicago; University of Pennsylvania; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; Eindhoven University of Technology
  摘要：Fluorescent diamond nanocrystals can host spin qubit sensors capable of probing the physical properties of biological systems with nanoscale spatial resolution. Sub-100 nm diamond nanosensors can readily be delivered into intact cells and even living organisms. However, applications beyond current proof-of-principle experiments require a substantial increase in sensitivity, which is limited by surface induced charge instability and electron-spin dephasing. In this work, we utilize engineered c...
• Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin AI翻译
  作者：Beccari, Melinda S.; Arnold-Garcia, Olatz; Baughn, Michael W.; Artates, Jonathan W.; McAlonis-Downes, Melissa; Lim, Jaisen; Leyva-Cazares, Dulce Fernanda; Rubio-Lara, Hugo Isaac; Ramirez-Rodriguez, Andrea; Bernal-Buenrostro, Carol N.; Murgia-Bay, Brian; Rangel, Carolina K.; Kim, Dong Hyun; Melamed, Ze'ev; Lutz, Cathleen M.; Lagier-Tourenne, Clotilde; Corbett, Kevin D.; Lopez-Erauskin, Jone; Cleveland, Don W.
  作者单位：University of California System; University of California San Diego; Instituto de Investigacion Sanitaria Biogipuzkoa; CIBERNED; Universidad Autonoma de Baja California; Hebrew University of Jerusalem; Jackson Laboratory; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); University of California System; University of California San Diego; Pfizer; Pfizer USA
  摘要：Stathmin-2 (also known as SCG10) is encoded by the STMN2 gene, whose mRNA is one of the most abundantly expressed in human motor neurons. In almost all instances of ALS and other TDP-43 proteinopathies, stathmin-2 encoding mRNAs are cryptically spliced and polyadenylated in motor neurons, a pathogenic consequence of nuclear loss of function of the RNA binding protein TDP-43. While stathmin-2 has been shown to enhance regeneration after axonal injury to axons of cultured motor neurons, here, we...
• Physical exercise activates a PVN-NAc oxytocin circuit to relieve stress- induced depressive- like behaviors AI翻译
  作者：Xia, Jie; Zou, Yong; Cui, Yuqing; Zhang, Sen; Huo, Konglin; Liu, Wenbin; Huang, Zhuochun; Zhang, Qiang; Qi, Zhengtang; Liu, Weina
  作者单位：Shanghai Jiao Tong University; East China Normal University; East China Normal University; East China Normal University; East China Normal University
  摘要：Physical exercise is known to reduce depression, but the underlying brain mechanisms remain unclear. Based on a chronic restraint stress model in mice, we showed that 4-wk treadmill exercise profoundly maintained normal neural activity in the nucleus accumbens (NAc), in association with the prevention of depressive-like behaviors. Microarray analysis conducted in the NAc revealed that the oxytocin (OT) receptor displayed the most significant differential expression, implying a crucial involvem...
• Environmental resistome-guided development of resistance-tolerant antibiotics AI翻译
  作者：Peek, James; Bhattacharjee, Abir; Burian, Jan; Hsieh, David Chun- Cheng; Hernandez, Yozen; Ternei, Melinda; Panfil, Cecilia; Brady, Sean F.
  作者单位：Rockefeller University; Rockefeller University
  摘要：Failure to anticipate new forms of antibiotic resistance has led to resistance developing rapidly to virtually all antibiotics that have entered clinical use. Many of the most problematic types of resistance originated in the environment, where ancient arms races between antibiotic-producing microbes and their competitors have created vast arsenals of antibiotics and resistance. Seizing on the knowledge that resistance in nature is frequently a harbinger of future clinical resistance, we propo...
• Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans AI翻译
  作者：Yadav, Vikas; Averette, Anna Floyd; Upadhya, Rajendra; Heitman, Joseph
  作者单位：Duke University
  摘要：Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is a heterodimer consisting of a catalytic A subunit and a regulatory B subunit. Through downstream effectors, calcineurin signaling drives myriad responses in different organisms. In the fungal pathogenic Cryptococcus species complex that infects humans, calcineurin governs thermotolerance and is es...
• Learning to estimate sample-specific transcriptional networks for 7,000 tumors AI翻译
  作者：Ellington, Caleb N.; Lengerich, Benjamin J.; Watkins, Thomas B. K.; Yang, Jiekun; Adduri, Abhinav K.; Mahbub, Sazan; Xiao, Hanxi; Kellis, Manolis; Xing, Eric P.
  作者单位：Carnegie Mellon University; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; University College London; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Mohamed bin Zayed University of Artificial Intelligence MBZUAI
  摘要：Cancers are shaped by somatic mutations, microenvironment, and patient background, each altering gene expression and regulation in complex ways, resulting in heterogeneous cellular states and dynamics. Inferring gene regulatory networks (GRNs) from expression data can help characterize this regulation-driven heterogeneity, but network inference requires many statistical samples, limiting GRNs to cluster-level analyses that ignore intracluster heterogeneity. We propose to move beyond coarse ana...
• Activation dynamics of ubiquitin-specific protease 7 AI翻译
  作者：Valles, Gabrielle J.; Korchak, Emilie J.; Buehre, Dane H. Geddes -; Jaiswal, Nancy; Korzhnev, Dmitry M.; Bezsonova, Irina
  作者单位：University of Connecticut; Indiana University System; Indiana University Bloomington
  摘要：Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that plays a crucial role in cellular processes, including the maintenance of genome stability and regulation of antiviral and immune responses. Its dysfunction is linked to various cancers and neurodevelopmental disorders such as Hao-Fountain syndrome. Unlike other USP-family enzymes, the triad of catalytic residues in USP7 adopts an inactive conformation and undergoes rearrangement into the active state upon substrate binding....