21期

最新文章

• Population size interacts with reproductive longevity to shape the germline mutation rate AI翻译
  作者：Zhu, Luke; Beichman, Annabel; Harris, Kelley
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center
  摘要：Mutation rates vary across the tree of life by many orders of magnitude, with fewer mutations occurring each generation in species that reproduce quickly and maintain large effective population sizes. A compelling explanation is that large effective population sizes facilitate selection against weakly deleterious mutator alleles such as variants that modulate cell division or interfere with the molecular efficacy of DNA repair. However, while the fidelity of a single cell division largely dete...
• Mechanisms of photoreceptor protection upon targeting the Nrl-Nr2e3 pathway AI翻译
  作者：Murphy, Daniel P.; V. Kolesnikov, Alexander; Montana, Cynthia L.; Khaja, Zaid M.; Liu, Yu; Kefalov, Vladimir J.; Corbo, Joseph C.
  作者单位：Washington University (WUSTL); University of California System; University of California Irvine; Washington University (WUSTL); Saint Louis University; University of California System; University of California Irvine
  摘要：Acute knockout of the rod photoreceptor transcription factor Nrl delays retinal degeneration in multiple mouse models of blindness, but the downstream transcriptomic changes that mediate these therapeutic effects are unknown. Here, we show that acute Nrl knockout causes upregulation of a subset of cone genes in rods as well as downregulation of rod genes, including the rod-specific transcriptional repressor Nr2e3. We hypothesized that Nr2e3 downregulation might mediate some of the therapeutic ...
• Pattern formation along signaling gradients driven by active droplet behavior of cell swarms AI翻译
  作者：Ford, Hugh Z.; Celora, Giulia L.; Westbrook, Elizabeth R.; Dalwadi, Mohit P.; Walker, Benjamin J.; Baumann, Hella; Weijer, Cornelis J.; Pearce, Philip; Chubb, Jonathan R.
  作者单位：University of London; University College London; University of London; University College London; University of London; University College London; University of Bath; University of Dundee
  摘要：Gradients of extracellular signals organize cells in tissues. Although there are several models for how gradients can pattern cell behavior, it is not clear how cells react to gradients when the population is undergoing 3D morphogenesis, in which cell-cell and cell-signal interactions are continually changing. Dictyostelium cells follow gradients of their nutritional source to feed and maintain their undifferentiated state. Using lightsheet imaging to simultaneously monitor signaling, single-c...
• Nonenzymatic RNA copying with a potentially primordial genetic alphabet AI翻译
  作者：Fang, Ziyuan; Jia, Xiwen; Xing, Yanfeng; Szostak, Jack W.
  作者单位：Howard Hughes Medical Institute; University of Chicago; Harvard University; University of Chicago
  摘要：Nonenzymatic RNA copying is thought to have been responsible for the replication of genetic information during the origin of life. However, chemical copying with the and disfavors the incorporation of A and especially U because of the stronger G:C vs. A:U base pair and the weaker stacking interactions of U. Recent advances in prebiotic chemistry suggest that the 2- thiopyrimidines were precursors to the canonical pyrimidines, raising the possibility that they may have played an important early...
• β- Amyloid peptides enhance α- synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease (vol 98, pg 12245, 2001) AI翻译
  作者：Masliah, Eliezer; Rockenstein, Edward; Veinbergs, Isaac; Sagara, Yutaka; Mallory, Margaret; Hashimoto, Makoto; Mucke, Lennart
• Expert navigators deploy rational complexity-based decision precaching for large- scale real- world planning (vol 122, e2407814122, 2025) AI翻译
  作者：Velasco, Pablo Fernandez; Griesbauer, Eva-Maria; Brunec, Iva K.; Morley, Jeremy; Manley, Ed; McNamee, Daniel C.; Spiers, Hugo J.
• A model of d- wave superconductivity, antiferromagnetism, and charge order on the square lattice (vol 120, e2302701120, 2023) AI翻译
  作者：Christos, Maine; Luo, Zhu - Xi; Shackleton, Henry; Zhang, Ya - Hui; Scheurer, Mathias S.; Sachdev, Subir
• Immune perturbation by the ileal microbiota in multiple sclerosis AI翻译
  作者：Jensen, Lise Tarp; Fugger, Lars
  作者单位：Aarhus University; University of Oxford; University of Oxford
• Forecasting range shifts of dioecious plants under climate change AI翻译
  作者：Moutouama, Jacob K.; Compagnoni, Aldo; Miller, Tom E. X.
  作者单位：Rice University; Martin Luther University Halle Wittenberg; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
  摘要：Global climate change has triggered an urgent need for predicting the reorganization of Earth's biodiversity. For dioecious species (those with separate sexes), it is unclear how commonly unique climate sensitivities of females and males could influence projections for species-level responses to climate change. We developed demographic models of range limitation, parameterized from geographically distributed common garden experiments, with females and males of a dioecious grass species (Poa ar...
• Near-zero photon bioimaging by fusing deep learning and ultralow-light microscopy AI翻译
  作者：Sheneman, Lucas; Balogun, Sulaimon; Johnson, Jill L.; Harrison, Maria J.; Vasdekis, Andreas E.
  作者单位：University of Idaho; University of Idaho; University of Idaho; Cornell University; Boyce Thompson Institute for Plant Research; United States Department of Energy (DOE); Pacific Northwest National Laboratory
  摘要：Enhancing the reliability and reproducibility of optical microscopy by reducing specimen irradiance continues to be an important biotechnology target. As irradiance levels are reduced, however, the particle nature of light is heightened, giving rise to Poisson noise, or photon sparsity that restricts only a few (0.5%) image pixels to comprise a photon. Photon sparsity can be addressed by collecting approximately 200 photons per pixel; this, however, requires long acquisitions and, as such, sub...