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作者：Ishida, Toshiaki; Zhang, Yingying; Zhu, Hongbo; Fudano, Shoko; Peng, Yu; Seto, Yoshiya; Mashiguchi, Kiyoshi; Liu, Jiyun; He, Zuhua; Zhang, Shubiao; Yamaguchi, Shinjiro
作者单位：Kyoto University; Tohoku University; Shanghai Academy of Agricultural Sciences; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Fujian Agriculture & Forestry University; Guangdong Ocean University; Meiji University
摘要：Bioactive gibberellins (GAs) are a class of plant hormones that regulate various aspects of plant growth and development, and several key GA deactivation enzymes have been identified. In rice, non- 13- hydroxylated GAs have been shown to be deactivated via 160x,17- epoxidation by a cytochrome P450 monooxygenase, ELONGATED UPPERMOST INTERNODE the product of EUI from bioactive GA4, has shown weak bioactivity on rice seedlings, how 160x,17- epoxyGAs are further deactivated remains elusive. Here, ...
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作者：Avila, Bryant; Augusto, Pedro; Hashemi, Alireza; Phillips, David; Gili, Tommaso; Zimmer, Manuel; Makse, Hernan A.
作者单位：City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System; City College of New York (CUNY); University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; City University of New York (CUNY) System; Memorial Sloan Kettering Cancer Center; University of New Mexico; City University of New York (CUNY) System
摘要：Understanding the dynamical behavior of complex systems from their underlying network architectures is a long-standing question in complexity theory. Therefore, many metrics have been devised to extract network features like motifs, centrality, and modularity measures. It has previously been proposed that network symmetries are of particular importance since they are expected to underlie the synchronization of a system's units, which is ubiquitously observed in nervous system activity patterns...
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作者：Noack, Christopher; Jenderny, Sebastian; Giez, Christoph; Merza, Ornina; Hofacker, Lisa-Marie; Repnik, Urska; Bramkamp, Marc; Ochs, Karlheinz; Wittlieb, Joerg; Bosch, Thomas C. G.
作者单位：University of Kiel; Ruhr University Bochum; Francis Crick Institute; University of Kiel; University of Kiel; University of Kiel
摘要：Understanding how neural populations emerge to give rise to behavior is a major goal in neuroscience. Here, we explore the self-assembly of neural circuits in Hydra, an organism with a simple nervous system but no centralized information processing, to enhance the understanding of nervous system evolution. We define self-assembly as spontaneous organization of neurons into functional circuits without requiring a prespecified structural template. In this context, the N4 neuronal circuit, which ...
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作者：Pearson, Talima; Furstenau, Tara; Wood, Colin; Rigas, Vanessa; Drake, Kylie; Sahl, Jason; Maltinsky, Sara; Currie, Bart J.; Mayo, Mark; Hall, Carina; Keim, Paul; Fofanov, Viacheslav
作者单位：Northern Arizona University; Northern Arizona University; Charles Darwin University; Menzies School of Health Research; Royal Darwin Hospital; Royal Darwin Hospital
摘要：Genomic diversity in pathogen populations is foundational for evolution and adaptation. Understanding population- level diversity is also essential for tracking sources and revealing detailed pathways of transmission and spread. For bacteria, culturing, isolating, and sequencing the large number of individual colonies required to adequately sample diversity can be prohibitively time- consuming and expensive. While sequencing directly from a mixed population will show variants among reads, they...
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作者：Han, Jie; Wang, Shuideng; Zheng, Zhiqiang; Chen, Donglei; Zhang, Wenqi; Qu, Zhi; Cheng, Mingxing; Yao, Yiqing; Sitti, Metin; Dong, Lixin
作者单位：Xi'an Jiaotong University; Max Planck Society; City University of Hong Kong; Koc University
摘要：Soft magnetic miniature devices are crucial for applications in minimally invasive medicine, soft electronics, and robotics. While substantial progress has been made, current magnetic programming techniques are inherently tied to template-based and sequential fabrication processes. These processes limit scalability, precision, and programmability. Here, we present a template-free, integrative strategy that leverages interlayer stress-induced 3D shape morphing in xerogel-PDMS bilayer materials ...
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作者：Hoehne, Mila Y.; Milani, Wiebke; Ramlow, Kirsten; Bogdan, Sven
作者单位：Philipps University Marburg
摘要：Collective cell migration is a key driver of tissue morphogenesis and cancer invasion. Here, we identified the tumor suppressor Ras association domain-containing protein 8 (RASSF8) as a WAVE interactor required for border cell migration. RASSF8 colocalizes with F-actin and cell adhesion molecules at border cell-border cell contacts. Loss of RASSF8 function results in border cell cohesion defects, a phenotype associated with changes in the localization of the Echinoid (Ed) and Coracle (Cora). C...
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作者：Yin, Yaling; Gao, Di; Wang, Yali; Wang, Zhi-Hao; Wang, Xin; Ye, Jinwang; Wu, Dongqin; Fang, Lin; Pi, Guilin; Yang, Ying; Wang, Xiao-Chuan; Lu, Chengbiao; Ye, Keqiang; Wang, Jian-Zhi
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作者：Krauss, Florian; Baggenstos, Daniel; Schmitt, Jochen; Tuzson, Bela; Menking, James A.; Machler, Lars; Silva, Lucas; Grimmer, Markus; Capron, Emilie; Stocker, Thomas F.; Bauska, Thomas K.; Fischer, Hubertus
作者单位：University of Bern; University of Bern; Australian Antarctic Division; University of Tasmania; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA); Commonwealth Scientific & Industrial Research Organisation (CSIRO); INRAE; Communaute Universite Grenoble Alpes; Institut de Recherche pour le Developpement (IRD); Universite Grenoble Alpes (UGA); UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey
摘要：Using high-precision ice core measurements of CO2, S13C-CO2, CH4, and N2O, this study provides carbon isotope constraints on a sizeable, centennial-scale CO2 jump at the onset of Marine Isotope Stage 9 (MIS 9). The very end of the Heinrich stadial (HS) characterizing Termination IV (T-IV, ca. 343 to 333 ka ago) shows a 250-y-long jump in greenhouse gas concentrations, followed by a 1.3 ka gradual decline back to the initial concentration. During this so-called overshoot, CO2 and CH4 reach thei...
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作者：Wang, Zhen; Zhang, Xiaofan; Zhou, Can; Cao, Xiaofeng
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The start of seed germination is a major decision point in plant life cycle, which relies on seed stored mRNA. However, the underlying translational mechanism remains less illustrated. Here, we demonstrate that inhibiting translation using translation inhibitors and ribosome-defective mutants delays germination inArabidopsis. Through comprehensive transcriptome deep sequencing (RNA-seq) and polysome profiling analyses, we elucidated the dynamic interplay of regulation at the transcriptional an...
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作者：Gelastopoulos, Alexandros; Sage, Lucas; van de Rijt, Arnout
作者单位：University of Southern Denmark; Pompeu Fabra University; Barcelona School of Economics; Communaute d'universites et etablissements de Toulouse (Comue); Universite Toulouse 1 Capitole; European University Institute; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze e Tecnologie della Cognizione (ISTC-CNR)
摘要：Inequality in outcomes may emerge through a reinforcement process in which stochastic variation in values is determined by prior values but may also originate in preexisting differences in unobserved factors. A common approach toward differentiating between these origins in longitudinal data is to attribute systematic differences between units-differences in means or differences proportional to a time-varying group average-to unobserved heterogeneity. We show that any longitudinal data with sy...
