23期

最新文章

• Multiple cortical systems influence a single vibrissa muscle AI翻译
  作者：Maharjan, Aman; Guest, Jason M.; Rathelot, Jean- Alban; Osorio, Fiorella M. Gomez; Strick, Peter L.; Oberlaender, Marcel
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Vrije Universiteit Amsterdam; Max Planck Society; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital
  摘要：What is the neural substrate that enables the cerebral cortex to control a single mystacial vibrissa and orchestrate its movement? To answer this question, we injected rabies virus into the intrinsic muscle that protracts the rat C3 vibrissa and used retrograde transneuronal transport to identify the cortical neurons that influence the muscle. A surprisingly diverse set of cortical areas is the origin of disynaptic control over the motoneurons that influence the C3 protractor. More than two th...
• The highly conserved intron of tyrosine tRNA is critical for m1A58 modification and controls the integrated stress response AI翻译
  作者：Stuart, Catherine J.; Hurtig, Jennifer E.; Tzadikario, Talia; Thomas, Niki K.; Jain, Miten; van Hoof, Ambro
  作者单位：University of Texas System; University of Texas Health Science Center Houston; Northeastern University
  摘要：tRNA introns are a universally conserved feature of eukaryotic genomes, but the reason for their conservation has remained obscure. We have previously shown that a defect in the essential tRNA splicing endonuclease of yeast results in transcriptome remodeling, resembling that of the integrated stress response (ISR). In this study, we show that ISR activation in this mutant requires the canonical ISR components, including the collided ribosome sensor Gcn1. We further show that splicing of tyros...
• High- throughput metabolic engineering of Yarrowia lipolytica through gene expression tuning AI翻译
  作者：Jiang, Wei; Wang, Shengbao; Ahlheit, Daniel; Fumagalli, Tommaso; Yang, Zhijie; Ramanathan, Shreemaya; Jiang, Xinglin; Weber, Tilmann; Dahlin, Jonathan; Borodina, Irina
  作者单位：Technical University of Denmark; Aalborg University; University of Milano-Bicocca
  摘要：The challenge of accurately predicting which genetic alternations lead to the desired phenotype necessitates high-throughput metabolic engineering approaches where numerous hypotheses can be tested simultaneously. We describe the CRISPR-Cas9-based method TUNEYALI that enables high-throughput tuning of gene expression in the common industrial yeast Yarrowia lipolytica. The method is based on replacing the promoters of the target genes with native Y. lipolytica promoters of varying strengths or ...
• Shared disbelief and shared belief: Belief and disbelief as drivers of interpersonal neural synchronization during narrative processing AI翻译
  作者：Braun, Gabriel; Yeshurun, Yaara; Shetreet, Einat
  作者单位：Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv University
  摘要：Despite living in an era where the mere concept of truth is increasingly contested, the cognitive processes underlying the processing of information we believe or disbelieve remain largely unexplored. In this fMRI study, we investigated how belief modulates narrative processing through belief context-the initial information indicating the speaker's credibility-and actual belief-the truth value ultimately assigned by the listener. Across two experiments, participants listened to narratives prec...
• Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy AI翻译
  作者：Cao, Lideng; Li, Zaiye; Song, Dian; Xia, Xin; Zhang, Gaowei; Wang, Hang; Zhao, Hang
  作者单位：Sichuan University; Chinese Academy of Medical Sciences - Peking Union Medical College; Sichuan University; Sichuan University
  摘要：The dense extracellular matrix (ECM) of stroma-rich solid tumors acts as a significant barrier to effective chemotherapy by hindering drug penetration. In this study, a supra-molecular hydrogel was successfully developed, enabling the codelivery and sequential release of hydrophilic and lipophilic drugs designed to target the ECM. The hydrogel is easy to prepare, has self-healing properties and excellent biocompatibility. Upon administration, the hydrogel first releases pirfenidone to inhibit ...
• Deciphering decomposition pathways of high explosives with cryogenic X-ray Raman spectroscopy AI翻译
  作者：Mellone, Oscar A. Paredes; Nielsen, Michael H.; Babicz Jr, Jeffrey Thomas; Vinson, John; Willey, Trevor M.; Sokaras, Dimosthenis
  作者单位：United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; National Institute of Standards & Technology (NIST) - USA
  摘要：We employed cryogenic X-ray Raman spectroscopy to investigate the early-stage decomposition of the high explosive molecule hexanitrohexaazaisowurtzitane (CL-20). By systematically varying the radiation dose under cryogenic conditions, we induced the decomposition of the molecule using ionizing radiation and observed the evolution of spectral features at the carbon, nitrogen, and oxygen K edges. Through extensive first-principles calculations, we identified key intermediates in the early stages...
• Study design and the sampling of deleterious rare variants in biobank-scale datasets AI翻译
  作者：Steiner, Margaret C.; Rice, Daniel P.; Biddanda, Arjun; Ianni-Ravn, Mariadaria K.; Porras, Christian; Novembre, John
  作者单位：University of Chicago; Massachusetts Institute of Technology (MIT); Johns Hopkins University; Icahn School of Medicine at Mount Sinai; University of Chicago
  摘要：One key component of study design in population genetics is the geographic breadth of a sample (i.e., how broad a region across which individuals are sampled). How the geographic breadth of a sample impacts observations of rare, deleterious variants is unclear, even though such variants are of particular interest for biomedical and evolutionary applications. Here, in order to gain insight into the effects of sample design on ascertained genetic variants, we formulate a stochastic model of disp...
• Early dynamics of chromatin decompaction drive nuclear stiffening AI翻译
  作者：Ivanovska, Irena L.
  作者单位：University of Pennsylvania
• Suborbital- and millennial- scale monsoon variability during Pleistocene interglacials AI翻译
  作者：Sun, Youbin; Wang, Ting; Yin, Qiuzhen; Clemens, Steven C.; Liu, Xingxing; Ai, Li; Wu, Zhipeng; Qiang, Xiaoke; Wang, Xulong; Chang, Hong; Song, Yougui; Vogel, Hendrik; Dodson, John; Berger, Andre; An, Zhisheng
  作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Hubei Engineering University; Universite Catholique Louvain; Brown University; University of Bern; University of Bern; University of New South Wales Sydney; Laoshan Laboratory
  摘要：Observational and modeling results show that the frequency and amplitude of extreme climatic events have increased significantly in the context of global warming. However, whether abrupt climate changes intensified during past warm periods remains poorly constrained due to the lack of high- resolution geological records. Here, we report a 512- m predominantly lacustrine sedimentary record from the Weihe Basin (North China), revealing that lake levels fluctuated significantly on suborbital (hal...
• Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen AI翻译
  作者：Zhang, Yibei; Xiao, Gang; Ding, Haoyuan; Zou, Qian; Gu, Dan; Wen, Jiachen; Pei, Yonggang; Guo, Rongxian; Wang, Qiyao; Zhou, Xiaohui
  作者单位：Southern University of Science & Technology; East China University of Science and Technology; Yangzhou University; Shenyang Pharmaceutical University; Henan University of Science & Technology
  摘要：Two-component system (TCS) histidine kinases enable bacterial pathogens to sense environmental signals and regulate adaptive responses during infection. The EnvZ/ OmpR TCS, known for its role in osmolarity/pH-dependent regulation of outer membrane porins across bacterial species, is also a central virulence regulator. However, the environmental cues that activate EnvZ/OmpR to trigger pathogenicity have remained unclear, limiting our understanding of host-pathogen interactions. Here, we demonst...