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作者：Kang, Sukjae J.; Liu, Shijia; Kim, Jong-Hyun; Kim, Dong-Il; Oh, Tae Gyu; Peng, Jiahang; Ye, Mao; Lee, Kuo-Fen; Evans, Ronald M.; Goulding, Martyn; Han, Sung
作者单位：Salk Institute; Salk Institute; Salk Institute; Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Harvard University; Howard Hughes Medical Institute; Harvard Medical School; Institute for Basic Science - Korea (IBS); University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of California System; University of California San Diego
摘要：Pain is both a sensory and emotional experience caused by various harmful stimuli. While numerous studies have explored peripheral and central pain mechanisms, the specific neural circuits linking the spinal cord to the brain remain poorly defined. In this study, we demonstrate the involvement of calcitonin gene- related peptide (CGRP)- positive neurons in the parvicellular part of the subparafascicular nucleus (SPFp) in pain. Tracing dorsal horn. Increased calcium activity was observed in CGR...
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作者：Lang, Jaclyn; Wake, Preston
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Michigan State University
摘要：Let N and p be prime numbers with p >= 5 such that p || (N + 1). In a previous paper, we showed that there is a cuspform f of weight 2 and level t0(N2) whose -th pound Fourier coefficient is congruent to pound + 1 modulo a prime above p for all primes pound. In this paper, we prove that this form f is unique up to Galois conjugacy, and the extension of Zp generated by the coefficients of f is exactly Zp[zeta p + 1-1]. We also prove similar results when a higher power of p divides N + 1.
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作者：Basavaraj, Chinmai; Reimann, Martin; Barnard, Kobus; Nadel, Lynn
作者单位：University of Arizona; University of Arizona; University of Arizona
摘要：This research investigates the neurophysiological mechanisms of experiential versus monetary choices under risk. While ventral striatum and insula activity are instrumental in predicting monetary choices, we find that hippocampal activity plays a key role in predicting experiential choices, which we theorize is due to its role in retrieving autobiographical memories. This neurophysiological differentiation clarifies observed variations in risk preferences between experiential and monetary pros...
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作者：Eckey, Martha; Li, Peng; Morrison, Braxton; Bergquist, Jonas; Davis, Ronald W.; Xiao, Wenzhong
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Uppsala University; Stanford Medicine; Stanford University
摘要：Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are persistent multisystem illnesses affecting many patients. With no known effective FDA-approved treatments for either condition, patient-reported outcomes of treatments may prove helpful in identifying management strategies that can improve patient care and generate new avenues for research. Here, we present the results of an ME/CFS and long COVID treatment survey with responses from 3,925 patients. We assess the exp...
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作者：Horwitz, Elad; Dubash, Taronish D.; Szabolcs, Annamaria; Wittner, Ben S.; Kreuzer, Johannes; Morris, Robert; Bardia, Aditya; Chirn, Brian; Wiley, Devon; Che, Dante; Russell, Hunter C.; Lopez, Xcanda Ixchel Herrera; Fox, Douglas B.; Antmen, Ezgi; Burr, Risa; Ting, David T.; Haas, Wilhelm; Sade-Feldman, Moshe; Maheswaran, Shyamala; Haber, Daniel A.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：The mitotic inhibitor docetaxel (DTX) is often used to treat endocrine-refractory metastatic breast cancer, but initial responses are mitigated as patients develop disease progression. Using a cohort of ex vivo cultured circulating tumor cells (CTCs) from patients with heavily pretreated breast cancer (n=18), we find distinct patterns of response to DTX, which are intrinsic and independent of past clinical treatment with taxanes. In some CTC cultures, treatment with a single dose of DTX result...
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作者：Beerendonk, Lola; Mejias, Jorge F.; Nuiten, Stijn A.; de Gee, Jan Willem; Zantvoord, Jasper B.; Fahrenfort, Johannes J.; van Gaal, Simon
作者单位：University of Amsterdam; University of Amsterdam; University of Amsterdam; University of Basel; University of Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
摘要：Performance typically peaks at moderate arousal levels, consistent with the Yerkes-Dodson law, as confirmed by recent human and mouse pupillometry studies. Arousal states are influenced by neuromodulators like catecholamines (noradrenaline and dopamine) and acetylcholine. To investigate their contributions to this law, we pharmacologically enhanced arousal while measuring human decision-making and spontaneous arousal fluctuations via pupil size. The catecholaminergic agent atomoxetine increase...
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作者：Meng, Lin; Feng, Jifan; Guo, Tingwei; Zhang, Mingyi; Cha, Sa; Chen, Peng; Ziaei, Heliya; Harouni, Aaron; Ho, Thach - Vu; Chai, Yang
作者单位：University of Southern California; Jilin University
摘要：Mechanical forces are ubiquitous and essential during vertebrate development, yet how these forces are translated into biochemical signals and regulate development during postnatal organogenesis remains poorly understood. While early embryogenesis relies on cell-autonomous mechanotransduction, the role of sensory innervation-abundant in postnatal stages-has been overlooked. Here, using the postnatal mouse molar development model, a system experiencing sustained mechanical forces and extensive ...
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作者：Zhu, Luke; Beichman, Annabel; Harris, Kelley
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作者：Dablander, Fabian; Lange, Florian; Brick, Cameron; Aron, Adam R.
作者单位：University of Amsterdam; University of Amsterdam; KU Leuven; University of Amsterdam; University of California System; University of California San Diego
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作者：Lord, Edana; Feinauer, Isabelle S.; Soares, Andre E. R.; Lagerholm, Vendela K.; Naesvall, Karin; Ersmark, Erik; Olsen, Remi- Andre; Prost, Stefan; Kuzmina, Elena A.; Smirnov, Nickolay G.; Stewart, John R.; V. Knul, Monika; Noiret, Pierre; Germonpre, Mietje; Ehrich, Dorothee; Pokrovsky, Ivan; Fedorov, Vadim B.; V. Goropashnaya, Anna; Dalen, Love; Diez-del-Molino, David
作者单位：Swedish Museum of Natural History; Stockholm University; Swedish Museum of Natural History; Uppsala University; Stockholm University; Wellcome Trust Sanger Institute; Stockholm University; University of Vienna; South African National Biodiversity Institute; Russian Academy of Sciences; Institute of Plant & Animal Ecology of the Russian Academy of Sciences; Bournemouth University; University of Winchester; University of Liege; Royal Belgian Institute of Natural Sciences; UiT The Arctic University of Tromso; Max Planck Society; University of Alaska System; University of Alaska Fairbanks
摘要：The Norwegian lemming (Lemmus lemmus) is a small rodent distributed across the Fennoscandian mountain tundra and the Kola Peninsula. The Norwegian lemming likely evolved during the Late Pleistocene and inhabited Fennoscandia shortly prior to the Last Glacial Maximum. However, the exact timing and origins of the species, and its phylogenetic position relative to the closely related Siberian lemming (Lemmus sibiricus) remain disputed. Moreover, the presence of ancient or contemporary gene flow b...
