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作者：Aumann, Roswitha A.; Gouvi, Georgia; Gregoriou, Maria - Eleni; Rehling, Tanja; Sollazzo, Germano; Bourtzis, Kostas; Schetelig, Marc F.
作者单位：Imperial College London; Justus Liebig University Giessen; Justus Liebig University Giessen; International Atomic Energy Agency; University of Patras
摘要：The Sterile Insect Technique (SIT) is a species-specific and environmentally friendly method for effectively controlling pest insect populations based on releasing reared, sterile insects into infested areas. Sex sorting in rearing facilities, enabling male-only releases, is necessary to ensure SIT programs are efficient, cost-effective and, in case of mosquito control, also safe. This can be greatly facilitated by genetic sexing strains (GSS), exhibiting sex-specific phenotypic markers. Howev...
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作者：Crawford, Conor J.; Tomlinson, Charles W. E.; Gunawan, Christian; Chen, Zongjia; Byrne, Dominic P.; Darby, Cosette; Conti, Martina L. G.; Larson, Tony; Luis, Ana S.; Elli, Stefano; Yates, Edwin A.; Bolam, David N.; van der Post, Sjoerd; Williams, Spencer J.; Cartmell, Alan
作者单位：Max Planck Society; University of York - UK; University of York - UK; University of York - UK; University of Melbourne; University of Melbourne; University of Liverpool; Newcastle University - UK; University of Gothenburg; SciLifeLab; University of Gothenburg
摘要：Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease (IBD) in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, and they are elevated in human IBD and correlate with disease severity.Selective inhibitors of carbohydrate sulfatases could function as sulfatase-selective drugs, allowing precise control of sulfatase activity while preserving these otherwise beneficial bacteria. Arylsulfamates ar...
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作者：Mason, Nigel John
作者单位：University of Kent
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作者：Pang, Damian K. F.; Pang, Severin K. Y.; Broeker, Marianne D.; Hibble, Alix
作者单位：University of Oxford; University of St Andrews
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作者：Pelech, Petr; Navarro, Paula P.; Vettiger, Andrea; Chao, Luke H.; Allolio, Christoph
作者单位：Charles University Prague; University of Lausanne; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：In order to proliferate, bacteria must remodel their cell wall at the division site. The division process is driven by the enzymatic activity of peptidoglycan synthases and hydrolases around the constricting Z-ring. We introduce a morphoelastic model that correctly reproduces the shape of the division site during the constriction and septation phases of Escherichia coli. In the model, mechanical stress directs the transformation of the bacterial wall. The two constants associated with growth a...
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作者：Pecorari, Rosalba; Mancini, Mara; Smirnov, Artem; Corleone, Giacomo; Novelli, Flavia; Lena, Anna Maria; Canonico, Mariacristina Franzese; Montanaro, Manuela; Cappello, Angela; Sacconi, Andrea; Misso, Gabriella; Falco, Michela; Tammaro, Chiara; Ciccosanti, Fabiola; Piacentini, Mauro; Scimeca, Manuel; Caraglia, Michele; Blandino, Giovanni; Mauriello, Alessandro; Fanciulli, Maurizio; Melino, Gerry; Candi, Eleonora
作者单位：IRCCS Istituto Dermopatico dell'Immacolata (IDI); University of Rome Tor Vergata; University of Hawaii System; Cancer Research Center of Hawaii; Universita della Campania Vanvitelli
摘要：Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive malignancy. While significant advances have been made in the management of low-grade cancer, treatment of advanced HNSCC remains challenging. Here, we used a proteomic approach to find binding partners of the oncogene p63, the most frequently amplified transcription factor in HNSCC. We identified a zinc finger protein, ZNF148, which is coexpressed and physically binds p63 in carcinoma cells. Genome occupancy analyses iden...
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作者：Gao, Qiao; Dai, Yi-Fei; Zhao, Yu-Lian; Li, Xue; An, Hao-Min; King-Jones, Kirst; Wang, Jia-Lu; Wang, Xiao-Ping; Liu, Wen
作者单位：Huazhong Agricultural University; University of Alberta
摘要：To adapt to seasonal changes, many animals, particularly insects, enter a dormancy-like condition known as diapause, which is primarily accomplished by sensing photoperiodic signals. The circadian clock, which is driven by positive regulators Clock (CLK) and Cycle (CYC), and negative regulators Period and Timeless, is thought to mediate this response. However, it remains unclear whether diapause induction involves a canonical rhythmic mechanism or occurs independently of their traditional role...
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作者：Palumbos, Sierra D.; Popolow, Jacob; Goldsmith, Juliet; Holzbaur, Erika L. F.
作者单位：University of Pennsylvania; Pennsylvania Medicine
摘要：Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and aggregated proteins. However, the late onset of diseases suggests that compensatory quality control mechanisms may be engaged to delay these deleterious effects. Neurons expressing common familial Parkinson's disease-associated mutations in the leucine-rich repeat kinase 2 (LRRK2) exhibit defective autophagy. Here, we demonstrate that both primary murine n...
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作者：Soni, Sourabh; Yildiz, Soner; Allen, Emma Kaitlynn; Petersen, Hans; Peeples, Mark; El Zahed, Sara; Rosas, Lorena; Anang, Vandana; Antonescu, Laura; Nho, Richard Seonghun; Mora, Ana Lucia; Horowitz, Jeffrey Craig; Rojas, Mauricio; Medina, Rafael Andres; Thomas, Paul Glyndwr; Garcia-Sastre, Adolfo; Tesfaigzi, Yohannes; Mebratu, Yohannes Afework
作者单位：University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; St Jude Children's Research Hospital; Lovelace Respiratory Research Institute; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; Center for Vaccines & Immunity; Emory University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, and influenza-infected human cohort. In airway epithelial cells (AECs), BIK deficiency impaired viral replication, while BIK restoration enhanced it. Conversely, airway-specific BIK overexpression in mice increased viral load, inflammation, and mortality, whe...
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作者：Yang, Ying; Ma, Yuanqing; Tilley, Richard D.; Gooding, J. Justin
作者单位：University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; European Molecular Biology Laboratory (EMBL); University of New South Wales Sydney
摘要：In superresolution optical fluctuation imaging (SOFI), molecules spaced closer than the diffraction limit can be separated through spatial and temporal correlation analysis of the fluorescence intensity fluctuations. The resolution and speed of SOFI imaging greatly depend on the characteristics of these fluorescence fluctuations. Fluorophores with stochastic and rapid fluorescence fluctuations are favorable for improving SOFI imaging resolution and speed, especially in high-order cumulant anal...
