28期

最新文章

• Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut AI翻译
  作者：Donald, Katherine; Serapio-Palacios, Antonio; Bozorgmehr, Tahereh; Ma, Mandi; Garcia, Ma Andrea Isabelle; Petersen, Charisse; Mandhane, Piushkumar; Subbarao, Padmaja; Moraes, Theo J.; Simons, Elinor; Turvey, Stuart; Azad, Meghan B.; Finlay, B. Brett
  作者单位：University of British Columbia; University of British Columbia; University of California System; University of California Davis; University of British Columbia; BC Children's Hospital; University of Alberta; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; McMaster University; University of Manitoba; University of Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba (CHRIM); University of Manitoba; University of British Columbia
  摘要：The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerous breastmilk components to gut microbiota and immune maturation remain unclear. Secretory IgA (SIgA), the most abundant antibody in human milk, is a key modulator of gut microbiota composition. We have shown previously that mouse milk SIgA protects against asthma by limiting segmented filamentous ...
• Structure-based discovery of positive allosteric modulators of the A1 adenosine receptor AI翻译
  作者：Nguyen, Anh T. N.; Panel, Nicolas; Vo, Duc Duy; Thai, Bui San; Chia, Ling Yeong; Lu, Cam Sinh; Hellyer, Shane D.; Langiu, Monica; Jorg, Manuela; Gregory, Karen J.; Kihlberg, Jan; White, Paul J.; Scammells, Peter J.; Christopoulos, Arthur; Carlsson, Jens; May, Lauren T.
  作者单位：Monash University; Uppsala University; Uppsala University; Monash University; Monash University
  摘要：Allosteric modulation of G protein-coupled receptors (GPCRs) is an exciting strategy for developing new therapeutic agents, and it has several advantages over more commonly used orthosteric drugs. Recently determined GPCR structures have revealed allosteric pockets facing the lipid bilayer, enabling rational drug design. Here, we develop a virtual screening strategy to discover ligands of extrahelical binding pockets and apply this approach to the adenosine A1 receptor (A1R). The A1R is a high...
• Acyl-CoA-binding protein as a driver of pathological aging AI翻译
  作者：Montegut, Lea; Lambertucci, Flavia; Moledo-Nodar, Lucas; Fiuza-Luces, Carmen; Rodriguez-Lopez, Carlos; Serra-Rexach, Jose Antonio; Lachkar, Sylvie; Motino, Omar; Abdellatif, Mahmoud; Durand, Sylvere; Aprahamian, Fanny; Carbonnier, Vincent; Le Corre, Delphine; Richard, Sophie Mouillet-; Chen, Hui; Sauvat, Allan; Dong, Yanbing; Li, Sijing; Rong, Yan; Pietrocola, Federico; Puig, Pierre Laurent-; Lopez-Otin, Carlos; Martins, Isabelle; Barcena, Clea; Lucia, Alejandro; Kroemer, Guido
  作者单位：Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut Universitaire de France; Sorbonne Universite; UNICANCER; Gustave Roussy; University of Oviedo; Instituto de Salud Carlos III; General University Gregorio Maranon Hospital; Complutense University of Madrid; Universidad de Valladolid; Medical University of Graz; Institut Universitaire de France; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Karolinska Institutet; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; Universidad Antonio de Nebrija; European University of Madrid; Icahn School of Medicine at Mount Sinai
  摘要：The tissue hormone acyl coenzyme A-binding protein (ACBP, encoded by the gene diazepam-binding inhibitor, DBI) has been implicated in various facets of pathological aging. Here, we show that ACBP plasma concentrations are elevated in (close-to-)centenarians (mean +/- SD age 99.5 +/- 4.5 y) commensurate with their health deterioration, correlating with a reduced glomerular filtration rate and a surge in senescence-associated cytokines. ACBP neutralization by means of a monoclonal antibody (mAb)...
• SARS- CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells AI翻译
  作者：Yang, Bo; Hu, Ao; Wang, Tiantian; Chen, Xiaolin; Ma, Caina; Yang, Xinyue; Deng, Kai
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
  摘要：Virus-induced excessive inflammatory response is a key contributor to pathology in respiratory viral infections. However, the underlying mechanisms by which viral infection provokes intense inflammatory reaction and how sustained inflammation leads to tissue damage are not fully understood. Using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as an example, our research demonstrates that SARS-CoV-2 infection can induce PANoptosis in bystander cells, contributing to the ...
• Orientation fields predict human perception of 3D shape from shading AI翻译
  作者：Aubuchon, Celine; Vergne, Romain; Cholewiak, Steven A.; Kunsberg, Benjamin; Holtmann-Rice, Daniel; Zucker, Steven W.; Fleming, Roland W.
  作者单位：Justus Liebig University Giessen; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Alphabet Inc.; Google Incorporated; Yale University; Amazon.com; Alphabet Inc.; Google Incorporated
  摘要：How the brain recovers the three- dimensional structure of surfaces and objects from 2D retinal images remains mysterious. Shading patterns provide one of the most powerful-yet least understood-visual depth cues. Most theories assume the brain infers surface normals from luminance values. However, this seems unlikely as visual neurons are broadly insensitive to luminance. To identify alternative cues, we measured responses of model orientation- selective cell populations to images of shaded ob...
• Chlorophyll trends are negative for lakes but positive for estuarine-coastal waters AI翻译
  作者：Cloern, James E.; Jassby, Alan D.
  作者单位：United States Department of the Interior; United States Geological Survey; University of California System; University of California Davis
  摘要：Nutrient (nitrogen and phosphorus) pollution is an environmental problem of global concern because overenrichment of water bodies increases phytoplankton biomass and ecosystem metabolism, depletes oxygen in bottom waters, and increases the frequency and intensity of harmful algal blooms. These responses to nutrient pollution have motivated policies to reduce anthropogenic nutrient inputs. However, these policies have not been universally implemented and their success at reducing phytoplankton ...
• EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants AI翻译
  作者：Takeuchi, Marie; Matsunaga, Mami; Kita, Tomoko; Nishimura, Koji; Tona, Yosuke; Omori, Koichi; Katsuno, Tatsuya; Nakagawa, Takayuki
  作者单位：Kyoto University; Kyoto University
  摘要：The mammalian cochlea loses its ability to regenerate hair cells (HCs) after birth. In contrast, in the avian auditory epithelium, the basilar papilla (BP), supporting cells (SCs) retain the capability for HC regeneration throughout life. Our previous study using single-cell RNA sequencing indicated a stepwise fate conversion of SCs to HCs via a precursor state, in which endothelin receptor type B2 (EDNRB2) exhibited specifically high expression during HC regeneration in chick BP. This study a...
• Inherent instability leads to high costs of hovering in near-neutrally buoyant fishes AI翻译
  作者：Disanto, Valentina; Qi, Xuewei; Berio, Fidji; Albi, Angela; Akanyeti, Otar
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; Stockholm University; University of Konstanz; Max Planck Society; University of Konstanz; University of Konstanz; Aberystwyth University
  摘要：Hovering, the ability to maintain a stationary position in fluid, is essential for many fish species during prey capture, habitat exploration, and mating. While traditionally assumed to be energetically inexpensive for fishes with a swim bladder, the metabolic costs and morphological factors influencing postural stability during hovering remain poorly understood. Hovering requires fishes to counteract small instabilities in position and orientation, often through continuous adjustments using t...
• Temperature-invariant crystal-glass heat conduction: From meteorites to refractories AI翻译
  作者：Simoncelli, Michele; Fournier, Daniele; Marangolo, Massimiliano; Balan, Etienne; Beneut, Keevin; Baptiste, Benoit; Doisneau, Beatrice; Marzari, Nicola; Mauri, Francesco
  作者单位：University of Cambridge; Columbia University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Sorbonne Universite; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Sapienza University Rome
  摘要：The thermal conductivities of crystals and glasses vary strongly and with opposite trends upon heating, decreasing in crystals and increasing in glasses. Here, we show that the dominant conduction mechanisms of crystals (particle-like propagation) and glasses (wave-like tunneling) can compensate in materials with crystalline bond order and nearly glassy bond geometry, yielding a hybrid crystal-glass conductivity that is constant from the quantum to the classical regime (i.e., from below to abo...
• Reply to Dablander et al.: Identifying interventions that change intentions lays a valuable foundation for behavior change AI翻译
  作者：Sinclair, Alyssa H.; Cosme, Danielle; Lydic, Kirsten; Reinero, Diego A.; Mann, Michael E.; Falk, Emily B.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania