30期

最新文章

• Electroreception in treehoppers: How extreme morphologies can increase electrical sensitivity AI翻译
  作者：England, Sam J.; Palmer, Ryan A.; O'Reilly, Liam J.; Chenchiah, Isaac, V; Robert, Daniel
  作者单位：University of West England; University of Bristol; Leibniz Institut fur Evolutions und Biodiversitatsforschung; University of Bristol; University of Bristol
  摘要：The link between form and function of an organism's morphology is usually apparent or intuitive. However, some clades of organisms show remarkable diversity in their form, often exhibiting extreme morphologies, but with no obvious functional explanation. Treehoppers (Membracidae) are a family of insects that exemplify this, displaying an astounding morphological diversity, resulting in a plethora of extreme forms. The function of these morphological extremities and the reasons for their evolut...
• Optimal kinetics for catalytic cycles from a single path-sampling simulation AI翻译
  作者：Bolhuis, Peter G.
  作者单位：University of Amsterdam
  摘要：A catalyst's efficiency for accelerating a reaction rate is determined by its molecular structure and interactions with the substrate. While one can predict kinetics for a particular molecular model, tuning the (potentially many) model parameters to reach a desired or optimal kinetics for a catalytic cycle is usually considered computationally prohibitively expensive, especially in solvated systems. Here, we show for a simple model representing a minimal catalytic cycle that such optimization ...
• Stress- induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy AI翻译
  作者：Lee, Amy S.
  作者单位：University of Southern California; University of Southern California
  摘要：Since their discoveries in the 1960s as a family of proteins produced by cells in response to stress, molecular chaperones are increasingly recognized as major regulators of cellular homeostasis in health and disease. Among the heat shock protein 70 family, the 78-kDa glucose-regulated protein (GRP78), also referred to as BiP and encoded by the HSPA5 gene, contains a signal peptide targeting it into the endoplasmic reticulum (ER). Through its interaction with the transmembrane ER stress sensor...
• Mechanistic insights into the iron-sulfur cluster- dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2 AI翻译
  作者：Liu, Haobo; Shen, Liqiang; Gong, Xinyu; Zhou, Xindi; Huang, Yichao; Zhou, Yuqian; Guo, Zhenpeng; Guo, Hanbo; Wang, Shichao; Pan, Lifeng
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：NCOA4, a dedicated autophagy receptor for mediating selective autophagy of ferritin (ferritinophagy), plays a vital role in maintaining cellular iron homeostasis. The cellular abundance of NCOA4 is regulated by the E3 ligase HERC2 that can specifically tar- get NCOA4 for proteasomal degradation under iron-- replete conditions. However, the detailed molecular mechanism governing the iron-- dependent recognition of NCOA4 by HERC2 remains elusive. Here, using multidisciplinary approaches, we syst...
• Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers AI翻译
  作者：Zhang, Yaling; Huang, Jian- Guo; Wang, Minhuang; Wang, Wenjin; Yang, Feiyu; Deslauriers, Annie; Fonti, Patrick; Liang, Eryuan; Maekinen, Harri; Oberhuber, Walter; Rathgeber, Cyrille B. K.; Tognetti, Roberto; Treml, Vaclav; Yang, Bao; Zhai, Lihong; Antonucci, Serena; Butto, Valentina; Camarero, J. Julio; Campelo, Filipe; Cufar, Katarina; De Luis, Martin; Fajstavr, Marek; Giovannelli, Alessio; Gricar, Jozica; Gruber, Andreas; Gryc, Vladimir; Gueney, Aylin; Jyske, Tuula; Kaspar, Jakub; King, Gregory; Krause, Cornelia; Lemay, Audrey; Lombard, Fabio; Castillo, Edurne Martinez del; Morin, Hubert; Nabais, Cristina; Noejd, Pekka; Peters, Richard L.; Prislan, Peter; Saracinoa, Antonio; V. Shishovbb, Vladimir; Vavrciks, Hanus; Vieirac, Joana; Zengd, Qiao; Rossi, Sergio
  作者单位：Chinese Academy of Sciences; South China Botanical Garden, CAS; Zhejiang University; Guangdong Academy of Sciences; Institute of Eco-environmental & Soil Sciences, Guangdong Academy of Sciences; University of Quebec; University of Quebec Chicoutimi; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Tibetan Plateau Research, CAS; Center for Excellence in Tibetan Plateau Earth Sciences (CETES), CAS; Natural Resources Institute Finland (Luke); University of Innsbruck; Universite de Lorraine; AgroParisTech; Free University of Bozen-Bolzano; Charles University Prague; Nanjing University; University of Molise; University of Quebec; University Quebec Abitibi-Temiscamingue; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); Universidade de Coimbra; University of Ljubljana; Johannes Gutenberg University of Mainz; Mendel University in Brno; Slovenian Forestry Institute; Izmir Katip Celebi University; University of Alberta; Universita Mediterranea di Reggio Calabria; Technical University of Munich; University of Naples Federico II; Siberian Federal University; Guangdong Academy of Sciences; Guangzhou Institute of Geography, Guangdong Academy of Sciences
  摘要：Controlled experiments suggest that the seasonal build-up of nitrogen (N) limitation constrains the responses of forest autumn phenology to elevated temperatures. Therefore, rising soil N is expected to increase the delaying effects of elevated temperature on the end of the season, i.e., leaf senescence. However, the interactive effects of temperature, soil N, and aridity on xylem autumn phenology remain unknown. We conducted a wide spatial analysis from 75 conifer sites in the Northern Hemisp...
• The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge AI翻译
  作者：Rockenbach, Johnny A. Z.; Nader, Guilherme P. F.; Antoku, Susumu; Gundersen, Gregg G.
  作者单位：Columbia University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
  摘要：The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occurs is unclear. Here, we sought to identify the kinesin motor protein(s) that is involved in recycling endocytosed integrin back to the plasma membrane. We show that the kinesin- 2 heterodimer, KIF3AC, and the Rab11 adaptor protein Rab coupling protein (RCP) are required for FA reformation after th...
• Mapping the development of neural structures supporting literacy AI翻译
  作者：Roy, Ethan
  作者单位：Stanford University
• Cdc42 defect reveals insights into microvilli organization and function in T cell immunity AI翻译
  作者：Soh, Won-Chang; Park, Sang-Moo; Park, Jeong-Su; Karabulut, Hatice; Kang, Hee-Tae; Kang, Sun-Kyoung; Kim, Min-Sang; Park, Jihwan; Lee, Sunjae; Kim, Hye-Ran; Jun, Chang-Duk
  作者单位：Gwangju Institute of Science & Technology (GIST); Gwangju Institute of Science & Technology (GIST); National Cancer Center - Korea (NCC)
  摘要：Microvilli on T cells differ from those on epithelial cells, exhibiting filopodia-like characteristics that facilitate the clustering of molecules essential for sensing and cell migration. Recently, they have also been recognized as the structures from which T cell immunological synaptosomes (TIS) are released. In this study, we examined a key determinant of microvilli organization during T cell development and explored the functional roles of these structures, particularly in relation to T ce...
• Differential representations of spatial location by aperiodic and alpha oscillatory activity in working memory AI翻译
  作者：Bender, Andrew; Zhao, Chong; Vogel, Edward; Awh, Edward; Voytek, Bradley
  作者单位：University of California System; University of California San Diego; University of Chicago; University of Chicago; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Decades of research have shown working memory (WM) relies on sustained prefrontal cortical activity and visual extrastriate activity, particularly in the alpha (8 to 12 Hz) frequency range. This alpha activity tracks the spatial location of WM items, even when spatial position is task-irrelevant and no stimulus is currently being presented. Traditional analyses of putative oscillations using bandpass filters, however, conflate oscillations with nonoscillatory aperiodic activity. Here, we reana...
• Kinetic pathways of solid-solid phase transitions dictated by short-range interactions AI翻译
  作者：Pan, Hillary; Dshemuchadse, Julia
  作者单位：Cornell University
  摘要：Structural phase transformations allow us to design materials from the ground up. Predicting the structural transformation of crystals during solid-solid phase transitions, however, is challenging, as the transition can proceed through multiple pathways that are difficult to probe experimentally. Using minimal computational models, we show that distinct kinetic pathways between body-centered cubic (bcc) and face-centered cubic (fcc) crystal structures can be encoded into a system by specific p...