30期

最新文章

• Tensor-based quantum phase difference estimation for large-scale demonstration AI翻译
  作者：Kanno, Shu; Sugisaki, Kenji; Nakamura, Hajime; Yamauchi, Hiroshi; Sakuma, Rei; Kobayashi, Takao; Gao, Qi; Yamamoto, Naoki
  作者单位：Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Keio University; Keio University; Keio University; SoftBank Corporation; JSR Corporation; Keio University
  摘要：We develop an energy calculation algorithm leveraging quantum phase difference estimation (QPDE) scheme and a tensor-network-based unitary compression method in the preparation of superposition states and time-evolution gates. Alongside its efficient implementation, this algorithm reduces depolarization noise affections exponentially. We demonstrated energy gap calculations for one-dimensional Hubbard models on IBM superconducting devices using circuits up to 32-system (plus oneancilla) qubits...
• Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+T cell pools across the human lifespan AI翻译
  作者：Menon, Tejas; McQuilten, Hayley A.; Samir, Jerome; Nguyen, Thi H. O.; Lim, Ratana; Kaur, Jasveen; Rizzetto, Simone; Eltahla, Auda; Thomas, Paul G.; Lappas, Martha; Rossjohn, Jamie; Gras, Stephanie; Crowe, Jane; Flanagan, Katie L.; Luciani, Fabio; Doherty, Peter C.; van de Sandt, Carolien E.; Kedzierska, Katherine
  作者单位：University of Melbourne; Peter Doherty Institute; University of New South Wales Sydney; University of Melbourne; University of Tasmania; University of Tasmania; St Jude Children's Research Hospital; Monash University; Monash University; Cardiff University; La Trobe University; Royal Melbourne Institute of Technology (RMIT); Launceston General Hospital; Clifford Craig Foundation
  摘要：Central memory CD8+T cells (Tcm) represent the prominent memory T cell subset in human blood, yet the persistence of T cell receptor (TCR) clonotypic and transcriptional features of epitope-specific Tcm pools across the human lifespan remains unknown. We analyzed Tcm CD8+ T cells specific for HLA-A*02:01-M158-66 (A2/M158; a prominent influenza epitope) in newborns, children, adults, and older adults directly ex vivo. Our data provide evidence that epitope-specific Tcm CD8+ pools dominate influ...
• Implementation science aims to improve healthcare by validating effective interventions AI翻译
  作者：Carey, John
• Exploring the social life of urban spaces through AI AI翻译
  作者：Salazar-Miranda, Arianna; Fan, Zhuangyuan; Baick, Michael; Hampton, Keith N.; Duarte, Fabio; Loo, Becky P. Y.; Glaeser, Edward; Ratti, Carlo
  作者单位：Yale University; University of Hong Kong; Michigan State University; Massachusetts Institute of Technology (MIT); Harvard University; Polytechnic University of Milan
  摘要：We analyze changes in pedestrian behavior over a 30-y period in four urban public spaces located in New York, Boston, and Philadelphia. Building on William Whyte's observational work, which involved manual video analysis of pedestrian behaviors, we employ computer vision and deep learning techniques to examine video footage from 1979-80 and 2008-10. Our analysis measures changes in walking speed, lingering behavior, group sizes, and group formation. We find that the average walking speed has i...
• Mechanistic modeling or machine learning for detecting variants of concern: Why not both? AI翻译
  作者：Wilke, Claus O.; Vieira, Luiz C.
  作者单位：University of Texas System; University of Texas Austin
• Spatiotemporal decoupling of floristic endemism in response to Qinghai-Tibet Plateau uplift AI翻译
  作者：Yang, Bao; Wang, Xuelian
  作者单位：Nanjing University; Chinese Academy of Sciences; Northwest Institute of Eco-Environment & Resources, CAS
• Supporting Information for Seigneur et al., Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs (vol 115, pg E10235, 2018) AI翻译
  作者：Seigneur, Erica; Polepalli, Jai S.; Sudhof, Thomas C.
• Seed dispersal disruption limits tropical forest regrowth AI翻译
  作者：Fricke, Evan C.; Cook-Patton, Susan C.; Harvey, Charles F.; Terrer, Cesar
  作者单位：Massachusetts Institute of Technology (MIT); Nature Conservancy
  摘要：Identifying linkages between biodiversity loss and climate change is required for understanding the scope of these interconnected challenges and developing approaches to address them. One crucial yet underexplored aspect is the influence of seed-dispersing animals on forest carbon storage. Here, we show that 81% of tropical trees rely on animals for seed dispersal and that disruption of this process, due to declines in animal diversity and movement, significantly hampers the carbon accumulatio...
• Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice AI翻译
  作者：Coskun, Reyan; Chang, ZeNan L.; Rodriguez, Athziri Marcial; Liu, Haoxin; Cheng, Jiye; Alippe, Yael; Diamond, Michael S.; Gordon, Jeffrey I.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Environmental causes of intrauterine growth restriction (IUGR) remain poorly characterized. Here, we compare germ-free (GF) and conventionally raised (CONV-R) mice to assess the effects of the gut microbiota on placental/fetal development at embryonic day (E)11.5 (end of placentation) and E17.5 (near term). Pregnancy-and microbiota-associated changes in gene expression occur along the gut, including those related to angiogenesis, while bacterial composition and fermentation activity remain sta...
• SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus AI翻译
  作者：Huang, Yunyun; Zhu, Yue; Zhu, Yueyan; Jiang, Yan; Xie, Yunli
  作者单位：Fudan University; Fudan University; Fudan University
  摘要：Embryonic neural progenitors give rise to adult neural stem cells (aNSCs), which share transcriptomic similarities with astrocytes while sustaining neurogenesis in the adult brain. How embryonic neural progenitors transit into aNSCs while preventing astrocyte fate to maintain the aNSC pool remains unclear. Here, we found that the Setdb1- mediated metabolic state is essential for the transition from embryonic neural progenitors to aNSCs. Loss of the histone methyltransferase SETDB1 during denta...