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作者：Vlcek, Jakub; Hamala, Tuomas; Cobo, Cristina Vives; Curran, Emma; Sramkova, Gabriela; Slotte, Tanja; Schmickl, Roswitha; Yant, Levi; Kolar, Filip
作者单位：Charles University Prague; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Natural Resources Institute Finland (Luke); University of Nottingham; Stockholm University; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; Swedish University of Agricultural Sciences
摘要：Genetic variation underpins evolutionary change, but mutation accumulation increases genetic load. Various factors affect the extent of load, such as population size and breeding system, but other important determinants remain unexplored. In particular, wholegenome duplication (WGD)-a pervasive macromutation occurring broadly across Eukaryotes-remains poorly understood in terms of its impact on neutral and selective processes within populations. Using iterative forward simulations and empirica...
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作者：Cui, Wenping; Fendley, Jemma M.; Srikant, Sriram; Shraiman, Boris I.
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Massachusetts Institute of Technology (MIT)
摘要：Bacteria and phages have been in an ongoing arms race for billions of years. To resist phages bacteria have evolved numerous defense systems, which nevertheless are still overcome by counterdefense mechanisms of specific phages. These defense/ counterdefense systems are a major element of microbial genetic diversity and have been demonstrated to propagate between strains by horizontal gene transfer (HGT). It has been proposed that the totality of defense systems found in microbial communities ...
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作者：Riaz, Muhammad Rizwan; Marquez, Ivan Sosa; Lindgren, Hanna; Levin, Garrett; Doyle, Rebecca; Romero, Mario Ceron; Paoli, Julia C.; Drnevich, Jenny; Fields, Christopher J.; Geddes, Barney A.; Marshall-Colon, Amy; Heath, Katy D.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; North Dakota State University Fargo; McMaster University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Plant-microbe symbioses such as the legume-rhizobium mutualism are vital in the web of ecological relationships within both natural and managed ecosystems, influencing primary productivity, crop yield, and ecosystem services. The outcome of these interactions for plant hosts varies quantitatively and can range from highly beneficial to even detrimental depending on natural genetic variation in microbial symbionts. Here, we take a systems genetics approach, harnessing the genetic diversity pres...
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作者：Chen, Panpan; Geng, Haoyuan; Ma, Bangzhen; Zhang, Yaqi; Zhu, Zihan; Li, Min; Chen, Shiping; Wang, Xiao; Sun, Chenglong
作者单位：Qilu University of Technology; Qilu University of Technology; Shandong First Medical University & Shandong Academy of Medical Sciences
摘要：Metabolic crosstalk among diverse cellular populations contributes to shaping a competitive and symbiotic tumor microenvironment (TME) to influence cancer progression and immune responses, highlighting vulnerabilities that can be exploited for cancer therapy. Using a spatial multiomics platform to study the cell- specific metabolic spectrum in hepatocellular carcinoma (HCC), we map the metabolic interactions between different cells in the HCC TME and identify a unique tumor- immune- cancer- as...
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作者：Fusco, Claudia M.; Staab, Anja; Bourke, Ashley M.; Tushev, Georgi; Desch, Kristina; Lins, Erico Moreto; Ciirdaeva, Elena; Dieck, Susanne tom; Kaltenschnee, Nina; Heckel, Alexander; Langer, Julian D.; Schuman, Erin M.
作者单位：Max Planck Society; Goethe University Frankfurt
摘要：Neurons rely on spatial and temporal control of protein synthesis to respond rapidly and locally to external stimuli, a process facilitated by the dynamic localization and modification of ribosomes. While previous research has shown that neuronal activity can regulate ribosome localization and modify translation rates, little is known about ribosomal assembly within neuronal processes. Here, we investigated the potential for local ribosome maturation in rat neurons using proteomics, RNA sequen...
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作者：Nair, Sreeja, V; Jaimon, Ebsy; Adhikari, Ayan; Nikoloff, Jonas; Pfeffer, Suzanne R.
作者单位：Stanford University
摘要：Parkinson's disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinson's disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks Hedgehog signaling and reduces synthesis of neuroprotective GDNF and NRTN, which normally support dopamine neurons vulnera...
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作者：Shao, Tianyu; Ma, Jiahao; Tan, Xinshui; Shan, Hongcheng; Xu, Dan; Zhang, Kexin; Zheng, Sanduo; Wang, Fengchao
作者单位：Peking University; National Institute of Biological Sciences, Beijing; Tsinghua University; Chinese Institute for Brain Research, Beijing
摘要：The acrosome is a crucial organelle essential for sperm function and male fertility. During acrosome biogenesis, numerous proacrosomal vesicles (PAVs) are transported to the concave region of the nuclear membrane and fuse to form the acrosome. However, the mechanisms governing the fusion of PAVs to form the acrosome remain poorly understood. Here, we identify endosome-lysosome associated apoptosis and autophagy regulator 1 (ELAPOR1), a conserved protein, as a key factor in PAVs fusion during a...
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作者：Yeh, Kenneth B.; Bahnfleth, William P.; Bradforda, Elaine; Cardona, Carol; Coleman, Kristen K.; Hudson, Peter J.; Dadonaite, Bernadeta; Hutchins, Rebecca J.; Maresso, Anthony; Macintyre, C. Raina; Scotch, Matthew
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Minnesota System; University of Minnesota Twin Cities; University System of Maryland; University of Maryland College Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University System of Georgia; Georgia Institute of Technology; Baylor College of Medicine; University of New South Wales Sydney; Kirby Institute; Arizona State University; Arizona State University-Downtown Phoenix
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作者：Kong, Sungsik; Solis-Lemus, Claudia; Tiley, George P.
作者单位：University of Wisconsin System; University of Wisconsin Madison; Brown University; University of Wisconsin System; University of Wisconsin Madison
摘要：Reticulate evolution has long been recognized as a key mechanism that contributes to genetic and trait diversity. With the widespread availability of genomic data, investigating historical reticulate evolution across taxa has gained significant attention, driven by the rapid development of statistical methods for detecting nontreelike patterns. Phylogenetic networks provide a biologically intuitive approach to depicting evolutionary processes such as hybrid speciation and introgressive hybridi...
