-
作者：Rahal, Rima - Maria; Spuntrup, Frederik Schulze
作者单位：Max Planck Society; Vienna University of Economics & Business
摘要：Whether and to what degree culture modifies cognition has been an area of research often limited by possibilities to gather relevant data across societies. In this project, we leverage webcam- based eye- tracking to study cultural variations of cognitive processes underlying in- group favoritism. Participants (n = 1850, k = 20) are assigned to an in- group based on a color perception task, complete a group reinforcement stage, and then make decisions to allocate points between themselves and r...
-
作者：Reny, Tyler T.; Roman, Marcel F.; Newman, Benjamin J.; Sears, David O.
作者单位：Claremont Colleges; Claremont Graduate University; Harvard University; University of California System; University of California Riverside; University of California System; University of California Riverside; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：One longstanding explanation for bias and excessive force in policing is selection-the assertion that those who select to work in law enforcement are more likely to hold far-right, intolerant, and antiegalitarian, views than the public. While intuitive and widely believed, the evidence in support of the selection hypothesis is surprisingly thin. We offer a vital contribution to the literature by exploring selection at one of its earliest phases: late adolescents entering college and the career...
-
作者：Brill, Julia; Clarke, Blaise; Hong, Ingie; Huganir, Richard L.
-
作者：Snead, Wilton T.; Skillicorn, Mary K.; Shrinivas, Krishna; Gladfelter, Amy S.
作者单位：Northwestern University; Feinberg School of Medicine; Duke University; Northwestern University; Northwestern University
摘要：Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. A major challenge lies in dissecting the multicomponent logic that relates biomolecular features to emergent condensate organization. Nuclear paraspeckles are paradigmatic examples of multidomain condensates, comprising core and shell layers with distinct compositions that are scaffolded by the ln...
-
作者：Ge, Qian; Zhang, Jinming; Huo, Qing; Yu, Jing; Zheng, Qiaohua; Qian, Zhaoqiang; Wei, Chunling; Jiang, Tongtong; Liu, Yihui; Liu, Zhiqiang; Ren, Wei; Sun, Zongpeng; Jia, Zhengping; Han, Jing
作者单位：Shaanxi Normal University; Air Force Medical University; Shaanxi Normal University; University of Toronto; Hospital for Sick Children (SickKids)
摘要：Memory generalization allows an organism to adapt to new conditions, but overgeneralization of fear or traumatic experiences can be detrimental to survival and contributes to the development of various mental disorders. However, the cellular and molecular mechanisms underlying fear memory generalization, especially in the hippocampus, remain largely unknown. In this study, utilizing a well-established mouse model of fear memory generalization, we investigated the role of endocannabinoids (eCBs...
-
作者：Roos, Christopher I.; Kaib, J. Mark; Laluk, Nicholas C.; Adams, Melinda M.; Guiterman, Christopher H.; Baisan, Christopher H.; Morino, Kiyomi; Swetnam, Thomas W.
作者单位：Southern Methodist University; United States Department of the Interior; US Fish & Wildlife Service; University of Arizona; University of California System; University of California Berkeley; University of Kansas; University of Kansas; University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA
摘要：Identifying the influence of low-density Indigenous populations in paleofire records has been methodologically challenging. In the Southwest United States, well-replicated fire histories suggest that abundant lightning and suitable climate conditions drove frequent low-severity wildfires in dry pine forests independent of human activities even as ethnography provided hints that highly mobile indigenous populations used fire in myriad land use contexts. Here, we leverage published and unpublish...
-
作者：Stein, Johannes; Ericsson, Maria; Nofal, Michel; Magni, Lorenzo; Aufmkolk, Sarah; Mcmillan, Ryan B.; Breimann, Laura; Herlihy, Conor P.; Lee, S. Dean; Willemin, Andrea; Wohlmann, Jens; Arguedas-Jimenez, Laura; Yin, Peng; Pombo, Ana; Church, George M.; Wu, Chao-ting
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Humboldt University of Berlin; University of Oslo
摘要：DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) enables nanoscale imaging with virtually unlimited multiplexing and molecular counting. Here, we address challenges, such as variable imaging performance and target accessibility, that can limit its broader applicability. Specifically, we enhance its capacity for robust single-protein imaging and molecular counting by optimizing the integration of total internal reflection fluorescence microscopy with physical sectioning, ...
-
作者：Hornick, Emma L.; Oxley, Kyp; Wieting, Nathaniel; Treco, Emma; Hostager, Bruce S.; Bishop, Gail A.
作者单位：University of Iowa; University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System
摘要：TNF receptor-associated factor 3 (TRAF3) is a signaling adaptor protein that is ubiquitously expressed but has highly distinct cell type-specific functions. TRAF3 plays critical roles in restraint of B lymphocyte activation, differentiation, and homeostatic survival. Consistent with such roles, loss-of-function mutations in TRAF3 have long been found in various human B cell malignancies. Mice lacking TRAF3 specifically in B cells have autoimmune manifestations, lymphadenopathy, and increased i...
-
作者：Miller, Shannon L.; Green, Katelyn M.; Crone, Bradley; Switzenberg, Jessica A.; Tank, Elizabeth M. H.; Krans, Amy; Jansen-West, Karen; Wieland, Clare M.; Ji, Eric W.; Petrucelli, Leonard; Barmada, Sami J.; Boyle, Alan P.; Todd, Peter K.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Mayo Clinic; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Despite its intronic location, this repeat avidly supports synthesis of pathogenic dipeptide repeat (DPR) proteins via repeat-associated non-AUG (RAN) translation. However, the template RNA species that undergoes RAN translation endogenously remains unclear. Using long-read based 5 ' RNA ligase-mediated rapid amplification of cD...
-
作者：Hoffmann, Celine; Filali, Liza; Wurzer, Hannah; Fernandes, Diogo Pereira; Mgrditchian, Takouhie; Huang, Wanxin; Moreau, Flora; Krecke, Max; Thomas, Clement
作者单位：Luxembourg Institute of Health; Luxembourg Institute of Health; University of Luxembourg; Eberhard Karls University of Tubingen
摘要：Natural killer (NK) cells engage target cells via the immunological synapse (IS), where inhibitory and activating signals determine whether NK cell cytotoxicity is suppressed or activated. We previously reported that cancer cells can rapidly remodel their actin cytoskeleton upon NK cell engagement, leading to F-actin accumulation at the synapse. Here, we show that this process inhibits NK cell activation as indicated by impaired MTOC and lytic granule polarization. Exploring the underlying mec...
