32期

最新文章

• A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratoderma AI翻译
  作者：Jiang, Xingyuan; Mortlock, Ryland D.; Pironon, Nathalie; Zhou, Jing; Hu, Ronghua; Liu, William; Acosta, Agustina; Shwayder, Tor A.; Hovnanian, Alain; Lifton, Richard P.; Choate, Keith A.
  作者单位：Yale University; Yale University; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Henry Ford Health System; Henry Ford Hospital; Rockefeller University; Yale University
  摘要：Genetic investigation in Mendelian skin disorders featuring generalized or localized skin scaling and redness, known as the ichthyoses, has revealed novel pathways relevant to epidermal integrity, barrier function, and desquamation. Here, we show that a recurrent de novo missense variant in EMP2 (epithelial membrane protein 2), which encodes a cell surface tetraspan protein in the growth- arrest specific 3 (GAS3)/peripheral myelin protein 22 (PMP22) family, is associated with a Mendelian skin ...
• A common denominator: PTSD, rapid eye movements, and fear extinction AI翻译
  作者：Uzoigwe, Chika Edward
• Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation AI翻译
  作者：Aslam, Sadaf; Sanchez-Aparicio, Maria T.; Siempelkamp, Braden D.; Dornan, Gillian L.; Tsolakos, Nikos; Burke, John E.; Hale, Benjamin G.; Sastre, Adolfo Garcia; Ayllon, Juan
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Universidad de Burgos; University of Victoria; University of Zurich; University of British Columbia; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being the main viral interferon antagonist. However, there are several interactions whose biological relevance remains obscure, such as the ability of NS1 to bind and activate class IA phosphoinositide 3-kinases (PI3Ks). PI3Ks are highly regulated lipid kinases that act as critical nodes in multiple cell...
• The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions AI翻译
  作者：Hudina, Esther; Schott-Verdugo, Stephan; Junglas, Benedikt; Kutzner, Mirka; Ritter, Ilona; Hellmann, Nadja; Schneider, Dirk; Gohlke, Holger; Sachse, Carsten
  作者单位：Helmholtz Association; Research Center Julich; Heinrich Heine University Dusseldorf; Helmholtz Association; Research Center Julich; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Heinrich Heine University Dusseldorf
  摘要：The phage shock protein A (PspA), a bacterial member of the endosomal sorting complexes required for transport (ESCRT)-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix alpha 0 of PspA (and other ESCRT-III members) has been suggested to act as a membrane anchor; the detailed mechanism, however, of how it binds to membranes and eventually triggers membrane fusion and/or fission events remains unclear. By solving a total of 15 cryoelectr...
• RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection AI翻译
  作者：Lari, Azra; Shah, Sahil B.; Mao, Xiaowen; Sanghrajka, Priyanka; Karijolich, John; Lareau, Liana F.; Glaunsinger, Britt A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Vanderbilt University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute
  摘要：The accumulation of RNA Polymerase III (Pol III) transcribed short interspersed nuclear element (SINE) retrotransposon RNA is a hallmark of various cellular stressors, including DNA virus infection. However, the molecular mechanisms driving the induction of these normally repressed loci are largely undefined. Here, we reveal that in addition to Pol III transcriptional induction, gammaherpesvirus infection stimulates mRNA-like 3 ' end processing of SINE RNAs that leads to their stabilization. W...
• Striatal and cerebellar interactions during reward-based motor performance AI翻译
  作者：Lee, Joonhee Leo; Casamento-Moran, Agostina; Bastian, Amy J.; Cullen, Kathleen E.; Chib, Vikram S.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Kennedy Krieger Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University
  摘要：Goal-directed motor performance relies on the brain's ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral for processing performance outcomes, yet their functional interactions remain underexplored. We scanned participants' brains with functional magnetic imaging (fMRI) while they performed a skilled motor task for monetary rewards, where outcomes depended on their motor performance and probabilistic...
• 20E-induced Kr-h1 expression facilitates developmental transitions depending on chromosome accessibility of BR-C enhancers AI翻译
  作者：Long, Shihui; Qiu, Yongyu; Lin, Tong; Huang, Shumin; Zhang, Wenhao; Liu, Suning; Tian, Ling; Palli, Subba R.; Li, Sheng; Li, Kang
  作者单位：South China Normal University; Huaihua University; Guangdong Laboratory for Lingnan Modern Agriculture; University of Kentucky; South China Normal University
  摘要：Transcription factors and histone modification-mediated chromatin accessibility coordinately regulate spatiotemporal expression of genes that control growth and development. It is well documented that juvenile hormone-activated Kr-h1 antagonizes 20-hydroxyecdysone (20E)-induced expression of the pupal specifier BR-C to sustain larval status in holometabolous insects. Here, we revealed that during the larval-prepupal transition in Drosophila melanogaster, the 20E-activated Kr-h1-BR-C axis is a ...
• 撤稿声明: Microtubule- associated protein 1 light chain 3 alpha (LC3)- associated phagocytosis is required for the efficient clearance of dead cells AI翻译
  作者：Martinez, Jennifer; Almendinger, Johann; Oberst, Andrew; Ness, Rachel; Dillon, Christopher P.; Fitzgerald, Patrick; Hengartner, Michael O.; Green, Douglas R.
• Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell-cell encounters AI翻译
  作者：Zbinden, Matti; Huisman, Jana S.; Blitvic, Natasha; Stocker, Roman; Slomka, Jonasz
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Massachusetts Institute of Technology (MIT); University of London; Queen Mary University London
  摘要：Conjugation accelerates bacterial evolution by enabling bacteria to acquire genes horizontally from their neighbors. Plasmid donors must physically encounter and connect with recipients to allow plasmid transfer, and different environments are characterized by vastly different encounter rates between cells, based on mechanisms ranging from simple diffusion to fluid flow. However, how the environment affects the conjugation rate by setting the encounter rate has been largely neglected, mostly b...
• Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect AI翻译
  作者：Dent, Matthew R.; DeMartino, Anthony W.; Xu, Qinzi; Chen, Xiukai; Gandhi, Alay; Hwang, Hyon S.; Bocian, Kaitlin A.; Correnti, Jacob E.; Abdelghany, Youmna; Alipour, Elmira; Ucer, K. Burak; Baker, Stephen R.; Kandada, Ajay Ram Srimath; Bulbul, Angka; Kim-Shapiro, Daniel B.; Rose, Jason J.; Tejero, Jesus; Gladwin, Mark T.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Maryland; University of Maryland Baltimore; Wake Forest University; Wake Forest University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Carbon monoxide (CO) poisoning causes 50,000 to 100,000 emergency department visits and similar to 1,500 deaths in the United States annually. Current treatments are limited to supplemental and/or hyperbaric oxygen to accelerate CO elimination. Even with oxygen therapy, nearly half of CO poisoning survivors suffer long-term cardiac and neurocognitive deficits related to slow CO clearance, highlighting a need for point of care antidotal therapies. Given the natural interaction between CO and fe...