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作者：Bonamassa, Ivan; Rath, Balazs; Posfai, Marton; Abert, Miklos; Keliger, Daniel; Szegedy, Balazs; Kertesz, Janos; Lovasz, Laszlo; Barabasi, Albert-Laszlo
作者单位：Budapest University of Technology & Economics; Northeastern University
摘要：We explore the impact of excluded volume interactions on the local assembly of linear physical networks, where nodes are spheres and links are rigid cylinders with varying length. To focus on the effect of elongated links, we introduce a minimal 3D model that helps us zoom into confined regions of these networks whose distant parts are sequentially connected by the random deposition of physical links with a very large aspect ratio. We show that the nonequilibrium kinetics at which these elonga...
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作者：Dong, Hao; Siddiquie, Reshma Y.; Xiao, Xuemei; Andrews, Michael; Bergman, Brian; Hui, Chung-Yuen; Jagota, Anand
作者单位：Lehigh University; Lehigh University; Cornell University; Michelin
摘要：Lubricated contacts in soft materials are important in various engineering systems and natural settings. Three major lubrication regimes are boundary (BL), mixed (ML), and elastohydrodynamic (EHL) lubrication, where the contact region is dry, partially wetted, or fully wetted, respectively. The transition between these regimes is insufficiently understood, especially for soft contacts, which impedes desired control of lubricated sliding friction. Here, we report on the role of solid wettabilit...
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作者：Richardson, Reese A. K.; Hong, Spencer S.; Byrne, Jennifer A.; Stoeger, Thomas; Amaral, Luis A. Nunes
作者单位：Northwestern University; Northwestern University; Northwestern University; University of Sydney; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University
摘要：Science is characterized by collaboration and cooperation, but also by uncertainty, competition, and inequality. While there has always been some concern that these pressures may compel some to defect from the scientific research ethos-i.e., fail to make genuine contributions to the production of knowledge or to the training of an expert workforce-the focus has largely been on the actions of lone individuals. Recently, however, reports of coordinated scientific fraud activities have increased....
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作者：Avaria-Llautureo, Jorge; Puschel, Thomas A.; Meade, Andrew; Baker, Joanna; Nicholson, Samuel L.; Venditti, Chris
作者单位：University of Reading; University of Oxford; Max Planck Society; Open University - UK
摘要：One of the most influential hypotheses about primate evolution postulates that their origin, radiation, and major dispersals were associated with exceptionally warm conditions in tropical forests at northern latitudes (henceforth the warm tropical foresthypothesis). However, this notion has proven difficult to test given the overall uncertainty about both geographic locations and paleoclimates of ancestral species. By the resolution of both challenges, we reveal that early primates dispersed a...
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作者：Kim, Jinyoung; Shirriff, Ashley; Cornwell, Jordan N.; Mutis, Maria Paula Quintero; Delis, Ereni; Wang, Sophia; Rootman, Daniel B.; Clites, Tyler R.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：The eyelid performs critical functions to protect the eye and preserve functional vision. These functions are driven by contraction of the orbicularis oculi (OO), which is a unique skeletal muscle with a circular geometry and diffuse innervation. It is thought that this distributed innervation may allow for differential segmental activation and contraction, but it is not currently understood how sequenced activation patterns relate to differential muscle contraction, nor how segmental contract...
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作者：Tillman, Nola Taylor
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作者：Huang, Aobo; Zhang, Jinming; Liu, Zhendong; Schoen, Vanessa; Verma, Deepanjali; Zheng, Haiyan; Pedmale, Ullas, V; Dong, Juan
作者单位：Rutgers University System; Rutgers University New Brunswick; Texas A&M University System; Texas A&M University College Station; Cold Spring Harbor Laboratory; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick
摘要：The formation of a body axis is one of the fundamental steps in developmental patterning in multicellular organisms. Ectopic expression of the stomatal protein BASL (BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE) reveals a proximal-distal cell polarity field in the leaf and an apical-basal field in the hypocotyl and root of Arabidopsis. This provides a framework for uncovering molecular components of body-axis cell polarity in higher plants. In this study, we developed a proximity labeling-bas...
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作者：Ravindran, Sandeep
摘要：Chris Greene grew up with an early interest in science. During his undergraduate studies at the University of Nebraska in Lincoln, he realized he wanted to focus on theoretical atomic, molecular, and optical (AMO) physics. With help from influential mentors such as his PhD advisor Ugo Fano, Greene went on to have a long and distinguished career as a theorist working in AMO physics and chemical physics. Over his career, he helped develop theories of few-body systems, particularly in ultracold g...
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作者：Vera, Axel O.; Truex, Nicholas L.; Sreekanth, Vedagopuram; Pentelute, Bradley L.; Choudhary, Amit; Raines, Ronald T.
作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of South Carolina System; University of South Carolina Columbia
摘要：Precise control over the dosage of Cas9-based technologies is essential because off-target effects, mosaicism, chromosomal aberrations, immunogenicity, and genotoxicity can arise with prolonged Cas9 activity. Type II anti-CRISPR proteins (Acrs) inhibit and control Cas9 but are generally impermeable to the cell membrane due to their size and anionic charge. Moreover, existing Acr delivery methods are long-lived and operate within hours (e.g., viral and nonviral vectors) or require external devi...
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作者：Hsu, Cheng Chih; Chamblee, Michelle; Ye, Chengjin; Shamseldin, Mohamed M.; Yoo, Sung J.; Li, Pei; Zhang, Yuexiu; Liu, Yajie; Hall, Jesse M.; Xu, Jiayu; Miao, Hanson; Thongpan, Ilada; Mahesh, K. C.; Liang, Xueya; Yount, Jacob S.; Peeples, Mark E.; Boyaka, Prosper N.; Dubey, Purnima; Martinez-Sobrido, Luis; Liu, Shan-Lu; Li, Jianrong
作者单位：University System of Ohio; Ohio State University; Texas Biomedical Research Institute; University System of Ohio; Ohio State University; Egyptian Knowledge Bank (EKB); Helwan University; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
摘要：The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monovalent SARS-CoV-2 vaccine expressing the six-proline-stabilized prefusion spike proteins (preS-6P) of Omicron XBB.1.5 based on the attenuated mumps virus (MuV) Jeryl Lynn (JL1) vaccine strain. We also developed an intranasal trivalent vaccine expressing the preS...
