2025

最新文章

• High- resolution national radon maps based on massive indoor measurements in the United States AI翻译
  作者：Li, Longxiang; Coull, Brent A.; Vieira, Carolina L. Zilli; Koutrakis, Petros
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Emory University; Rollins School Public Health; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Radon, a common radioactive indoor air pollutant, is the second leading cause of lung cancer in the United States. Knowledge about its distribution is essential for risk assessment and designing efficient protective regulations. However, the three current radon maps for the United States are unable to provide the up- to- date, high- resolution, and time- varying radon concentrations. Tens of millions of radon measurements have been conducted as parts of property inspections in the past two dec...
• Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts AI翻译
  作者：Lin, Long; Shen, Danyu; Shao, Xiaolong; Yang, Yicheng; Li, Li; Zhong, Caihong; Jiang, Jiandong; Wang, Mengcen; Qian, Guoliang
  作者单位：Nanjing Agricultural University; Chinese Academy of Sciences; Wuhan Botanical Garden, CAS; Nanjing Agricultural University; Zhejiang University; Zhejiang University
  摘要：Bacterial-fungal interaction (BFI) has significant implications for the health of host plants. While the diffusible antibiotic metabolite- mediated competition in BFI has been extensively characterized, the impact of intercellular contact remains largely elusive. Here, we demonstrate that the intercellular contact is a prevalent mode of interaction between beneficial soil bacteria and pathogenic filamentous fungi. By generating antibiotics- deficient mutants in two common soil bacteria, Lysoba...
• Discrepancies between subjective and objective sleep assessments revealed by in- home electroencephalography during real- world sleep AI翻译
  作者：Masaki, Minori; Tsumoto, Saki; Tani, Akihiro; Tominaga, Morie; Seol, Jaehoon; Chiba, Shigeru; Miyanishi, Kazuya; Nishida, Kei; Kawana, Fusae; Amemiya, Takashi; Hiei, Tetsuro; Kanbayashi, Takashi; Yanagisawa, Masashi
  作者单位：University of Tsukuba; University of Tsukuba; University of Tsukuba; National Center for Geriatrics & Gerontology; Tokyo Metropolitan Institute of Gerontology
  摘要：Sleep insufficiency and sleep disorders pose serious health challenges. This study aimed to determine the potential discrepancy between subjective and objective sleep assessments, including the latter made by physicians, by analyzing a 421- participant dataset in Japan comprising multiple nights of in- home sleep electroencephalogram (EEG) data and questionnaire responses on sleep habits or subjective experiences. We employed logistic regression models to examine which subjective and objective...
• Burrow collapse is not the only explanation for rapid, noncatastrophic preservation of 3D dinosaurs AI翻译
  作者：Wetherell, Meaghan M. Emery-
  作者单位：University of Arizona
• Hidden domain boundary dynamics toward crystalline perfection AI翻译
  作者：Mangu, Anudeep; Stoica, Vladimir A.; Zheng, Hao; Yang, Tiannan; Zhang, Maohua; Wang, Huaiyu (Hugo); Zu, Rui; Nguyen, Quynh L.; Song, Sanghoon; Das, Sujit; Meisenheimer, Peter; Donoway, Elizabeth; Chollet, Matthieu; Sun, Yanwen; Turner, Joshua J.; Freeland, John W.; Wen, Haidan; Martin, Lane W.; Chen, Long-Qing; Gopalan, Venkatraman; Zhu, Diling; Cao, Yue; Lindenberg, Aaron M.
  作者单位：Stanford University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Indian Institute of Science (IISC) - Bangalore; University of California System; University of California Berkeley; Rice University; Rice University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory
  摘要：A central paradigm of nonequilibrium physics concerns the dynamics of heterogeneity and disorder, impacting processes ranging from the behavior of glasses to the emergent functionality of active matter. Understanding these complex mesoscopic systems requires probing the microscopic trajectories associated with irreversible processes, the role of fluctuations and entropy growth, and the timescales on which nonequilibrium responses are ultimately maintained. Approaches that illuminate these proc...
• Moisture- driven carbonation kinetics for ultrafast CO2 mineralization AI翻译
  作者：Gao, Yining; Tao, Yong; Li, Gen; Shen, Peiliang; Pellenq, Roland J. M.; Poon, Chi Sun
  作者单位：Hong Kong Polytechnic University; Hong Kong Polytechnic University; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Ecole nationale superieure de chimie de Montpellier; Universite de Montpellier
  摘要：CO2 mineralization, a process where CO2 reacts with minerals to form stable carbonates, presents a sustainable approach for CO2 sequestration and mitigation of global warming. While the crucial role of water in regulating CO2 mineralization efficiency is widely acknowledged, a comprehensive understanding of the underlying mechanisms remains elusive. This study employs a combined experimental and atomistic simulation approach to elucidate the intricate mechanisms governing moisture- driven carb...
• Complex tissue regeneration in Lophuromys reveals a phylogenetic signal for enhanced regenerative in rodents AI翻译
  作者：Riddell, Brennan; Mcdonough, Molly; Ferguson, Adam; Kimani, John M.; Gawriluk, Thomas R.; Peng, Chi; Kiama, Stephen G.; Ezenwa, Vanessa O.; Seifert, Ashley W.
  作者单位：University of Kentucky; Chicago State University; Field Museum of Natural History (Chicago); University of Nairobi; University of Kentucky; Yale University
  摘要：Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling...
• Salmonella infection accelerates postnatal maturation of the intestinal epithelium AI翻译
  作者：Schloesser, Stefan; Ullrich, Anna-Lena; Modares, Nastaran Fazel; Schmitz, Matthias A.; Schoeneich, Johannes; Zhang, Kaiyi; Richter, Isabel; Robrahn, Laura; Schraven, Sarah; Nagai, James S.; Haange, Sven-Bastiaan; Jennings, Susan A. V.; Clavel, Thomas; Rolle-Kampczyk, Ulrike; Kiessling, Fabian; Costa, Ivan G.; Muncan, Vanesa; Repnik, Urska; von Bergen, Martin; Dupont, Aline; Hornef, Mathias W.
  作者单位：RWTH Aachen University; RWTH Aachen University Hospital; Hannover Medical School; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen University; RWTH Aachen University Hospital; University of Kiel; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
  摘要：Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Salmonella Typhimurium results in accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue. Using conditional Myd88- deficient mice, we identify the c...
• Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration AI翻译
  作者：Builhe, Beryl Laplace-; Tejedor, Gautier; De La Cruz, Jholy; Barthelaix, Audrey; Marmigere, Frederic; Sapede, Dora; Bahraoui, Sarah; Diouloufet, Lucie; Venteo, Stephanie; Collignon, Jerome; Jorgensen, Christian; Djouad, Farida
  作者单位：Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); CHU Lyon; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; CHU de Montpellier
  摘要：Unlike regeneration-competent species, mammals lack epimorphic regeneration capacity, except for the most distal part of their digits. Here, we show that E10.5 mouse embryos can initiate regeneration of their forelimb bud (FB), but this capacity is lost by E12.5. Using comparative transcriptomics and in vivo lineage tracing approaches in the mouse embryo, we were able to identify a population of neural crest-derived cells (NCdCs) reexpressing early NC lineage molecular markers, Wnt1 and Foxd3,...
• Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition AI翻译
  作者：Collura, Joseph L.; Lei, Kuan Cheok; Chandra, Mitalee; Kervarrec, Thibault; Park, Hyun Jung; Dalkoohi, Mazdak; Becker, Jurgen C.; Chang, Yuan; Moore, Patrick S.; Shuda, Masahiro
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pittsburgh Medical Center; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Universite de Tours; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Merkel cell polyomavirus (MCV) T antigen functions as an oncoprotein that drives the transformation of Merkel cell carcinoma (MCC) cells by activating transcription factors involved in cell proliferation. The viral T antigen promoter requires the activity of the cellular coactivator CREB-binding protein (CBP)/p300 for its expression. Inhibition of CBP/p300 with two distinct small-molecule inhibitors suppresses T antigen expression, leading to cell cycle arrest and upregulation of the cell cycl...