2025

最新文章

• Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms AI翻译
  作者：Hestehave, Sara; Florea, Roxana; Singleton, Samuel; Fedorec, Alex J. H.; Caxaria, Sara; Morgan, Oakley B.; Kopp, Katharina Tatjana; Brown, Laurence A.; Heymann, Tim; Sikandar, Shafaq; Hausch, Felix; Peirson, Stuart N.; Geranton, Sandrine M.
  作者单位：University of London; University College London; University of Dundee; University of London; Queen Mary University London; University of Munich; University of Oxford; Technical University of Darmstadt; Technical University of Darmstadt; University of Oxford; University of Copenhagen
  摘要：Chronic pain affects 20 to 30% of the population and imposes a significant socioeconomic burden as it is often accompanied by substantial emotional comorbidities such as anxiety and depression. Yet, the mechanisms underlying the interactions between the sensory and emotional aspects of chronic pain remain poorly understood. Here, we investigated the role of FKBP51, a regulator of the stress response, in mediating both sensory and emotional symptoms of chronic pain. Inhibition of FKBP51, via ge...
• Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation AI翻译
  作者：Mohyee, Raana A.; Elliott, Blake L.; Pike, Madeline R.; Smith, Emma; Kring, Ann M.; Olson, Ingrid R.; Breen, Elizabeth C.; Cohn, Barbara A.; Cirillo, Piera M.; Krigbaum, Nickilou Y.; Olino, Thomas M.; D'Esposito, Mark; Cogan, Ashby B.; Patwardhan, Bhakti P.; Ellman, Lauren M.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Public Health Institute
  摘要：In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the effects of prenatal maternal inflammation (PNMI) on offspring hippocampal microstructure in humans remain unclear. Here, we examined the relationship between exposure to PNMI and neurite density in the hippocampus and its subfields among offspring during late middle age. Participants included 72 ...
• Can neuromorphic computing help reduce AI's high energy cost? AI翻译
  作者：Ornes, Stephen
• Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo- EM AI翻译
  作者：Li, Zhuowen; Bharambe, Nikhil; Lande, Kashmiri Manishrao; Feddersen, Bjarne; Balakrishna, Asha Manikkoth; Biggin, Philip C.; Sahu, Giriraj; Basak, Sandip
  作者单位：Nanyang Technological University; Indian Institute of Science (IISC) - Bangalore; University of Oxford; Nanyang Technological University
  摘要：Pentameric ligand- gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Although the high- resolution structures of these channels have been elucidated, capturing their dynamic conformational transitions remains challenging due to the transient nature of intermediate states. In this study, we investigated a prokaryotic proton- gated pLGIC, GLIC. In our cryo- EM data at pH 4.0, we identified and segregated asymmetric parti...
• A megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor's appointment (vol 118, e2101165118, 2021) AI翻译
  作者：Milkman, Katherine L.; Patel, Mitesh S.; Gandhi, Linnea; Graci, Heather N.; Gromet, Dena M.; Ho, Hung; Kay, Joseph S.; Lee, Timothy W.; Akinola, Modupe; Beshears, John; Bogard, Jonathan E.; Buttenheim, Alison; Chabris, Christopher F.; Chapman, Gretchen B.; Choi, James J.; Dai, Hengchen; Fox, Craig R.; Goren, Amir; Hilchey, Matthew D.; Hmurovic, Jillian; John, Leslie K.; Karlan, Dean; Kim, Melanie; Laibson, David; Lamberton, Cait; Madrian, Brigitte C.; Meyer, Michelle N.; Modanu, Maria; Nam, Jimin; Rogers, Todd; Rondina, Renante; Saccardo, Silvia; Shermohammed, Maheen; Soman, Dilip; Sparks, Jehan; Warren, Caleb; Weber, Megan; Berman, Ron; Evans, Chalanda N.; Snider, Christopher K.; Tsukayama, Eli; Van den Bulte, Christophe; Volpp, Kevin G.; Duckworth, Angela L.
• Intracellular pH regulates ubiquitin- mediated degradation of the MAP kinase ERK3 AI翻译
  作者：Tesniere, Chloe; Boudghene-Stambouli, Fadia; Severin, Marc; Poet, Mallorie; Voisin, Laure; Ponniah, Muthulakshmi; Pascariu, Mirela; Bonneil, Eric; Trempef, Jean-Francois; Thibault, Pierre; Counillon, Laurent; Pedersen, Stine Falsig; Meloche, Sylvain
  作者单位：Universite de Montreal; Universite de Montreal; Universite de Montreal; University of Copenhagen; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; McGill University; McGill University; Universite de Montreal
  摘要：Intracellular pH (pHi) influences diverse cellular processes, including cell proliferation, metabolism, and migration, and is linked to metabolic diseases and cancer. Protonation alters protein charge and conformation, modulating different aspects of protein function. How pHi fluctuations are sensed by signaling proteins and translated into cellular responses remains incompletely understood. Here, we reveal that pHi plays a key role in regulating the stability of the mitogen-activated protein ...
• Descattering and image restoration with a transformer-based neural network in deep tissue imaging AI翻译
  作者：Xu, Xiangcong; Zhang, Renlong; Luo, Chenggui; Zhang, Chi; Li, Yanping; Lin, Danying; Yu, Bin; Liu, Liwei; Weng, Xiaoyu; Wang, Yiping; Kong, Lingjie; Li, Jia; Qu, Junle
  作者单位：Shenzhen University; Tsinghua University
  摘要：Imaging biological structures deep inside tissues is crucial but challenging due to common light scattering. This study proposes a multiattention network that directly maps degraded scattering two-photon excitation fluorescence (TPEF) images to high-quality scattering-free images, thereby computationally extending the imaging depth for TPEF without requiring complex optical additions. The model relies solely on simulated data rather than well-registered real data pairs, and is trained to desca...
• Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation AI翻译
  作者：Losi, Gabriele; Vignoli, Beatrice; Granata, Rocco; Lia, Annamaria; Zonta, Micaela; Sansevero, Gabriele; Pischedda, Francesca; Chiavegato, Angela; Santi, Spartaco; Zentilin, Lorena; Berardi, Nicoletta; Ratto, Gian Michele; Carmignoto, Giorgio; Canossa, Marco
  作者单位：Consiglio Nazionale delle Ricerche (CNR); University of Padua; University of Trento; University of Trento; Scuola Normale Superiore di Pisa; University of Padua; Consiglio Nazionale delle Ricerche (CNR); Istituto di Neuroscienze (IN-CNR); Consiglio Nazionale delle Ricerche (CNR); IRCCS Istituto Ortopedico Rizzoli; International Center for Genetic Engineering & Biotechnology (ICGEB); University of Florence; Consiglio Nazionale delle Ricerche (CNR); Istituto di Biofisica (IBF-CNR); Consiglio Nazionale delle Ricerche (CNR); Istituto Nanoscienze (NANO-CNR); European Academy of Bozen-Bolzano
  摘要：In the absence of explicit neuronal inputs, the glial cell astrocytes exhibit recurring intracellular Ca2+ fluctuations, primarily localized at thin processes, known as Ca2+ microdomains (MDs). Although spontaneous Ca2+ MDs are present throughout the brain, their putative role is unknown. Here, we question whether, owing to their recurring signaling mode, spontaneous Ca2+ MDs contribute to slowly evolving phenomena in the brain, such as memory consolidation. We demonstrate that, in the perirhi...
• Phylogenomics redefines the evolutionary history of mosquitoes AI翻译
  作者：Pierce, Mac P.; Worthington, Brian M.; Han, Shaolin; Ni, Xue-Bing; Liao, Yunshi; Shum, Marcus H.; Guan, Yi; Holmes, Edward C.; Lam, Tommy T.
  作者单位：University of Hong Kong; Shanghai Jiao Tong University; University of Sydney
  摘要：Mosquitoes have a substantial impact on human and animal health, but their deeper evolutionary relationships have been difficult to resolve. We inferred a time-calibrated phylogenetic history of mosquitoes using conserved genome-wide markers from representatives of major lineages. Our analyses revealed that codon bias and positive selection in subfamily Anophelinae contributed to a substantial level of branch attraction bias between Anophelinae and outgroup taxa, which in our view has misled p...
• Invariant HVC size in female canaries singing under testosterone: Unlocking function through neural differentiation, not growth AI翻译
  作者：Ma, Shouwen; Frankl-Vilches, Carolina; Gahr, Manfred
  摘要：Testosterone administration to nonsinging adult female canaries induces song, making this a model for behavioral plasticity and its underlying neural mechanisms in vertebrates. The song control nucleus HVC is traditionally believed to undergo a substantial size change when transitioning from a nonfunctional to a functional (song-producing) state. Using 2-photon in vivo imaging, we tracked the spatial distribution and anatomical properties of HVC neurons over several weeks of testosterone-induc...