2025

最新文章

• Wholesale flat subduction of the Indian slab and northward mantle convective flow: Plateau growth and driving force of the India-Asia collision AI翻译
  作者：Ma, Jincheng; Song, Xiaodong; Bunge, Hans-Peter; Fichtner, Andreas; Tian, You
  作者单位：Peking University; University of Munich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Jilin University
  摘要：The tectonic evolution of the Tibetan Plateau has been influenced by continental collision and postcollisional convergence of Indian and Eurasian plates, both of which have undoubtedly imposed their imprints on the lithosphere and upper-mantle structures beneath the collision zone. However, the mode by which the Indian Plate has subducted beneath Tibet, and its driving forces, have been highly uncertain. Here, we present seismic evidence from a full-waveform tomographic model that reveals flat...
• Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance AI翻译
  作者：Zhang, Boyao; Orning, Pontus; Lehman, Jesse W.; Dinis, Alexandre; Torres-Ulloa, Leslie; Elling, Roland; Kelliher, Michelle A.; Bertin, John; Proulx, Megan K.; Goguen, Jon D.; Ryan, Liv; Kandasamy, Richard K.; Espevik, Terje; Pai, Athma A.; Fitzgerald, Katherine A.; Lien, Egil
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Norwegian University of Science & Technology (NTNU); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Freiburg; University of Freiburg; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; GlaxoSmithKline; Glaxosmithkline USA; Sanofi-Aventis; Sanofi USA; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Mayo Clinic; Norwegian University of Science & Technology (NTNU); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor- interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis, and inflammation. Here, we found a pivotal role of Raver1 as an essential regulator of Ripk1 pre-mRNA splicing, expression, and functionality and the subsequent caspase-8- dependent inflammatory cell death. We show that Raver1 influences mRNA diversity ...
• Contextual neural dynamics during time perception in the primate ventral premotor cortex AI翻译
  作者：Diaz, Hector; Bayones, Lucas; Alvarez, Manuel; Andrade-Ortega, Bernardo; Valero, Sebastian; Zainos, Antonio; Romo, Ranulfo; Rossi-Pool, Roman
  作者单位：Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico
  摘要：Understanding how time perception adapts to cognitive demands remains a significant challenge. In some contexts, the brain encodes time categorically (as long or short), while in others, it encodes precise time intervals on a continuous scale. Although the ventral premotor cortex (VPC) is known for its role in complex temporal processes, such as speech, its specific involvement in time estimation remains underexplored. In this study, we investigated how the VPC processes temporal information d...
• A 5,000-fold increase in the HAT reactivity of a nonheme FeIV=O complex simply by replacing two pyridines of the pentadentate N4Py ligand with pyrazoles AI翻译
  作者：Pal, Nabhendu; Xiong, Jin; Jahja, Mehmet; Mahri, Sami; Young Jr, Victor G.; Guo, Yisong; Swart, Marcel; Que Jr, Lawrence
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Carnegie Mellon University; Universitat de Girona; Universitat de Girona; ICREA
  摘要：A pentadentate [N5] ligand (N2Py2Pz) based on the classic N4Py (N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) framework has been synthesized by replacing the two pyridylmethyl arms with corresponding (N-methyl)pyrazolylmethyl units to form [N-bis(1-methyl-2-pyrazolyl)methyl-N-(bis-2-pyridylmethyl)amine] (L1). The oxidation of the iron(II) precursor (N2Py2Pz)Fe-II(OTf)(2) (1) with ((BuSO2)-Bu-t)C6H4IO at 298 K leads to the formation of the [Fe-IV(O)(N2Py2Pz)](2+) intermediate (2) with a...
• Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis AI翻译
  作者：Quach, Diana; Sharp, Marc; Ahmed, Sara; Ames, Lauren; Bhagwat, Amala; Deshpande, Aditi; Parish, Tanya; Pogliano, Joe; Sugie, Joseph
  作者单位：Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of California System; University of California San Diego
  摘要：Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health threat, affecting an estimated 10.6 million people in 2022. The emergence of multidrug resistant and extensively drug resistant strains necessitates the development of novel and effective drugs. Accelerating the determination of mechanisms of action (MOAs) for these drugs is crucial for advancing TB treatment. This study introduces MycoBCP, a unique adaptation of bacterial cytological profiling (BCP) t...
• Electric transportation and electroreception in hummingbird flower mites AI翻译
  作者：Garcia-Rebeco, Carlos; Dierick, Diego; Manser, Konstantine
  作者单位：University of Connecticut; University of Bristol
  摘要：Electric fields in terrestrial environments are used by caterpillars to detect their predators, as foraging cues by pollinators, and facilitate ballooning by spiders. This study shows that electric fields facilitate transportation and detection of hummingbirds in a guild of tropical phoretic mites. Hummingbird flower mites feed on nectar and pollen and complete their life cycle inside flowers. Mites colonize new flowers by hitching rides on hummingbird beaks. Flower mites emerge from hummingbi...
• Future scientific innovation requires the transformative power of philanthropy (vol 121, e2420276121, 2024) AI翻译
  作者：Nestor, Michael W.; Cordova, France; Pines, Darryll; Merfeld, Danielle; Griffiths, Jennifer; McNutt, Marcia
• The importance of IP6 for ADAR RNA- editing enzymes and antiviral defense AI翻译
  作者：Bass, Brenda L.; Ranganathan, Supraja
  作者单位：University of Utah; Utah System of Higher Education; University of Utah
• Identification of ARHGEF11 (PDZ- RhoGEF) as an in vivo regulator of synapses and cognition AI翻译
  作者：Bjornson, Kathryn J.; Kermath, Bailey A.; Cahill, Michael E.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Given the influence of cognitive abilities on life outcomes, there is inherent value in identifying genes involved in controlling learning and memory. Further, cognitive dysfunction is a core feature of many neuropsychiatric disorders. Here, we use a combinatory in silico approach to identify human gene targets that will have an especially high likelihood of individually and directly impacting cognition. This broad and unbiased screen led to the specific identification of ARHGEF11, which encod...
• Reply to Boomsma: The evidence that eusociality evolved from monogamous ancestors is inconclusive AI翻译
  作者：Rees-Baylis, Ella; Pen, Ida; Kreider, Jan J.
  作者单位：University of Groningen; University of Bern