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作者：Kirkegaard, Karla
作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine
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作者：Munoz-Musat, Esteban; Le Coz, Arthur; Corcoran, Andrew W.; Belloli, Laouen; Naccache, Lionel; Andrillon, Thomas
作者单位：Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Hopital Universitaire Pitie-Salpetriere - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Pitie-Salpetriere - APHP; Monash University; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
摘要：Does being awake necessarily mean being conscious of something? This study investigates the phenomenon of mind blanking (MB), characterized by an emptiness of mind, comparing it with mind wandering (MW) and on- task (ON) states. Using a sustained attention task and electroencephalogram monitoring, behavioral, and neurophysiological signatures of MB were examined in 62 participants. MB exhibited a specific pattern of behavioral lapses, as well as decreased fast oscillatory activity and complexi...
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作者：Vierock, Johannes; Kaufmann, Joel C. D.; Faiss, Lukas; Tillert, Linda; Krause, Benjamin S.; Fischer, Paul; Nguyen, Thi Bich Thao; Schmitz, Dietmar; Rost, Benjamin R.; Bartl, Franz; Hegemann, Peter
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE)
摘要：Channelrhodopsins are light-gated ion channels that are used in modern neurosciences for the precise control of cellular ion fluxes by light. With a peak absorption at 585 nm, Chrimson is the most red-shifted cation-conducting ChR. It is frequently employed in multicolor experiments alongside blue light-sensitive optogenetic tools and is so far the only light-gated ion channel successfully applied in human vision restoration. However, its photoresponses to different wavelengths have not been t...
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作者：Petrova, Boryana; Syphurs, Caitlin; Culhane, Andrew J.; Chen, Jing; Chen, Ernie; Cotsapas, Chris; Esserman, Denise; Montgomery, Ruth R.; Kleinstein, Steven H.; Smolen, Kinga K.; Mendez, Kevin; Lasky-Su, Jessica; Steen, Hanno; Levy, Ofer; Diray-Arce, Joann; Kanarek, Naama
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Medical University of Vienna; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, emergence of less virulent variants, and antiviral medications, COVID-19 continues to take a significant toll. There are thousands of new hospitalizations and hundreds of deaths per week in the United States, many of whom develop long COVID. Early identification of individuals at high risk of severe COVID-19 is key for monitoring and supporting respiratory status and improving outc...
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作者：Tan, Miao-Miao; Sun, Xiao-Dong; Wang, Ye; Duan, Jian-Lu; Ma, Jing-Ya; Liu, Xiao-Yu; Liu, Mei-Yan; Sun, Yu-Chen; Xing, Rong-Xiang; Wang, Shu-Guang; Chen, Wel; Yuan, Xian-Zheng
作者单位：Shandong University; Nankai University; Shandong University
摘要：Atmospheric micro(nano)plastics (MNPs), including polyethylene terephthalate (PET), enter plants via leaves, accumulating in tissues. Foliar PET nanoplastic exposure alters Nicotiana benthamiana nicotine biosynthesis, favoring the more potent (S)-isomer even without growth inhibition. This accumulation reveals a contamination pathway for combustible consumer products, demonstrating that MNPs-induced alteration of a plant's endogenous biochemistry represents a significant and previously unchara...
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作者：Wang, Heng; Xu, Fang; Yao, Chenlu; Dai, Huaxing; Xu, Jialu; Wu, Bingbing; Tian, Bo; Shi, Xiaolin; Wang, Chao
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作者：Jia, Li; Liu, Mengdi; Ji, Huiyan; Lei, Jiaxin; Su, Danhua; Li, Lingyi; Liu, Ting; Yuan, Fenghong; Xu, Lin; Cao, Qinghua; Zhang, Huimin; Wen, Zhenke
作者单位：Soochow University - China; Soochow University - China; Nanjing Medical University; Jiangnan University; Zunyi Medical University; University of Sydney; Kolling Institute of Medical Research; Royal North Shore Hospital; University of California System; University of California Riverside
摘要：Lupus nephritis (LN), which is characterized by the accumulation of DNA- containing immune complexes (ICs), is the leading cause of death in patients with systemic lupus erythematosus (SLE). While growing evidence highlights the central role of CD103+ T cells in shaping the immune landscape of regional tissues, mechanisms driving the cell differentiation in LN remain largely unexplored. In this study, we identified an increased frequency of CD4+CD103+ T cells within the kidneys of SLE patients...
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作者：Magzamen, Sheryl
作者单位：Colorado State University System; Colorado State University Fort Collins
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作者：Wang, Pengcheng; Cleveland, Kristan H.; Shahid, Ayaz; Rathnayaka, Chathurika; Amirrad, Farideh; Song, Zhenpeng; Estillore, John Paul; Wang, Ruiwu; Back, Thomas G.; Chen, S. R. Wayne; Huang, Ying
作者单位：Western University of Health Sciences; Capital Medical University; Chapman University System; Chapman University; University of Calgary; Libin Cardiovascular Institute Of Alberta; University of Calgary
摘要：Epidermal growth factor (EGF) induces anchorage-independent growth in promotion-sensitive (P+) mouse epidermal cell model JB6 primarily through activation of the MAPK/ ERK signaling pathway. The beta- blocker carvedilol inhibits EGF-promoted JB6 transformation, but the underlying mechanism is unknown. Since carvedilol suppresses overactivated ryanodine receptors (RyRs) independently of its adrenergic blocking effects, we hypothesized that EGF-promoted transformation requires RyR-mediated calci...
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作者：Dunbar, Emily; Clark, Robert; Basle, Arnaud; Allyjaun, Shenaz; Newman, Hector; Hubbard, Julia; Khalid, Syma; van den Berg, Bert
作者单位：Newcastle University - UK; University of Oxford
摘要：Bacteriophages are bacterial viruses that provide alternatives to small-molecule drugs to combat infections by antibiotic-resistant bacteria. To infect a bacterial host, a phage needs to bind to the bacterial surface via receptor binding proteins (RBPs), which are critical for determining host specificity. For functionally important receptors, the RBP-receptor interaction could be exploited via phage steering, where emerging bacterial resistance due to receptor modification could make bacteria...
