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作者：Morrison, Robin E.; Ellis, Samuel; Martignac, Victoire; Stoinski, Tara S.; Eckardt, Winnie
作者单位：University of Zurich; University of Exeter
摘要：Evidence across a broad range of disciplines has demonstrated how individuals' social environments can impact their health, lifespan, reproduction, and ultimately their evolutionary fitness. Past research has primarily focused on either traits specific to individuals or wider traits of social groups, linking these with a component of fitness. In this study, we examined how both individual-and group-level social traits in 164 wild mountain gorillas combine to influence multiple pathways impacti...
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作者：Hand, Suzanne J.; Wilson, Laura A. B.; Lopez-Aguirre, Camilo; Houssaye, Alexandra; Archer, Michael; Bevitt, Joseph J.; Evans, Alistair R.; Halim, Amalia Y.; Hung, Tzong; Rich, Thomas H.; Vickers-Rich, Patricia; Beck, Robin M. D.
作者单位：University of New South Wales Sydney; Australian National University; Australian National University; University of Toronto; University Toronto Scarborough; Universidad de La Salle; Universidad Industrial de Santander; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Australian Nuclear Science & Technology Organisation; Monash University; University of New South Wales Sydney; University of New South Wales Sydney; Monash University; University of Salford
摘要：The platypus and four echidna species are the only living egg-laying mammals and the sole extant representatives of Order Monotremata. The platypus and echidnas are very disparate both morphologically and ecologically: The platypus is a specialized semiaquatic burrowing form that forages for freshwater invertebrates, whereas echidnas are fully terrestrial and adapted for feeding on social insects and earthworms. It has been proposed that echidnas evolved from a semiaquatic, platypus-like ances...
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作者：Marang, Christopher P.; Petersen, Daniel J.; Scott, Brent D.; Walcott, Sam; Debold, Edward P.
作者单位：University of Massachusetts System; University of Massachusetts Amherst; Worcester Polytechnic Institute; Worcester Polytechnic Institute; Worcester Polytechnic Institute
摘要：Intensely contracting fast skeletal muscle rapidly loses the ability to generate force, due in part to the accumulation of phosphate (Pi) inhibiting myosin's force-generating capacity, in a process that is strain dependent. Crucial aspects of the mechanism underlying this inhibition remain unclear. Therefore, we directly determined the effects of increasing [Pi] on rabbit psoas muscle myosin's ability to generate force against progressively higher resistive loads in a laser trap assay, with th...
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作者：McTavish, Emily Jane; Gerbracht, Jeff A.; Holder, Mark T.; Iliff, MarshallJ.; Lepage, Denis; Rasmussen, Pamela C.; Redelings, Benjamin D.; Reyes, Luna L. Sanchez; Miller, Eliot T.
作者单位：Cornell University; University of Kansas; University of Kansas
摘要：We present a complete, time-scaled, evolutionary tree of the world's bird species. This tree unites phylogenetic estimates for 9,239 species from 262 studies published between 1990 and 2024, using the Open Tree synthesis algorithm. The remaining species are placed in the tree based on curated taxonomic information. The tips of this complete tree are aligned to the species in the Clements Taxonomy used by eBird and other resources, and cross-mapped to other taxonomic systems including the Open ...
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作者：Ou, Haohong; Yang, Jingtao; Wang, Honglong; Kang, Nuoyao; Li, Shumin; Chen, Yuting; Peng, Zihao; Xiang, Xianzhe; Engel, Michael S.; Winterton, Shaun L.; Ren, Dong; Yang, Qiang; Shi, Chaofan
作者单位：Sun Yat Sen University; Guangzhou University; American Museum of Natural History (AMNH); California Department of Food & Agriculture; Capital Normal University
摘要：The form and change of animal biogeography reflects the long-term interplay between organisms and their environment, involving physiological limitation, dispersal capability, and adaptive evolution versus plate tectonics, global climatic shifts, and changing landscapes. This is especially manifest for lineages with extended geological histories, which, therefore, evokes questions as to the associated processes producing such patterns. Insects, as the earliest flying animals, have exceptional a...
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作者：Tumini, Emanuela; Wellinger, Ralf E.; Moyano, Emilia Herrera-; Cansino, Patricia Navarro-; Rubio, Maria Garcia-; Lloret, Daniel Salas-; Losada, Alejandro; Munoz-Alonso, Maria J.; Gaillard, Helene; Luna, Rosa; Aguilera, Andres
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; Universidad Pablo de Olavide; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); University of Sevilla
摘要：DNA topoisomerase 1 (TOP1) is essential for transcription, replication, and repair. Its function relies on two catalytic steps, DNA breakage and rejoining. Inhibitors of the second step prevent DNA rejoining and lead to persistent DNA breaks, acting as topoisomerase poisons, used as anticancer drugs. However, reliable inhibitors of the first step are not available. Here, we provide genetic and molecular evidence supporting that Patulin and, to a lesser extent, Xestoquinol inhibit the first cat...
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作者：Mitchison, Timothy J.
作者单位：Harvard University; Harvard Medical School
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作者：Tuck, Jeremy R.; Dunlap, Lee E.; Khatib, Yara A.; Hatzipantelis, Cassandra J.; Novak, Sammy Weiser; Rahn, Rachel M.; Davis, Alexis R.; Mosswood, Adam; Vernier, Anna M. M.; Fenton, Ethan M.; Aarrestad, Isak K.; Tombari, Robert J.; Carter, Samuel J.; Deane, Zachary; Wang, Yuning; Sheridan, Arlo; Gonzalez, Monica A.; Avanes, Arabo A.; Powell, Noel A.; Chytil, Milan; Engel, Sharon; Fettinger, James C.; Jenkins, Amaya R.; Carlezon Jr, William A.; Nord, Alex S.; Kangas, Brian D.; Rasmussen, Kurt; Liston, Conor; Manor, Uri; Olson, David E.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; Salk Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of California System; University of California Davis; University of California System; University of California Davis; Harvard University; Harvard University Medical Affiliates; McLean Hospital; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California San Diego; University of California System; University of California Davis
摘要：Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable ability to promote cortical neuron growth and increase spine density; however, these compounds are contraindicated for patients with SCZ or a family history of psychosis. Here, we report the molecular design and de novo total synthesis of (+)-JRT, a structural analogue of lysergic acid diethylamide...
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作者：Warden, Anna S.; Sharma, Nishant; Hutchens, Steven; Liu, Chunyi; Haggerty, Noah R.; Gurol, Kerem C.; Jursa, Thomas; Smith, Donald R.; Mayfield, Roy Dayne; Mukhopadhyay, Somshuvra
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of California System; University of California Santa Cruz; Chongqing Medical University; Chongqing Medical University
摘要：Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and environmental Mn overexposure is a global public health problem. To address this, here we combined unbiased transcriptomics and metabolomics with functional studies in a mouse model of human environmen...
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作者：Husremovic, Tarik; Meier, Vanessa; Piech, Lucas; Siess, Katharina M.; Antonioli, Sumire; Grishkovskaya, Irina; Kircheva, Nikoleta; Angelova, Silvia E.; Wenzl, Karoline; Brandstaetter, Andreas; Veis, Jiri; Miocic-Stosic, Fran; Anrather, Dorothea; Hartl, Markus; Truebestein, Linda; Cerron-Alvan, Luis M.; Leeb, Martin; Zagrovic, Bojan; Hann, Stephan; Bock, Christoph; Ogris, Egon; Dudev, Todor; Irwin, Nicholas A. T.; Haselbach, David; Leonard, Thomas A.
作者单位：Medical University of Vienna; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Bulgarian Academy of Sciences; University of Chemical Technology & Metallurgy - Bulgaria; BOKU University; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); University of Vienna; University of Vienna; Austrian Academy of Sciences; Medical University of Vienna; University of Sofia; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
摘要：The phosphoinositide 3- kinase (PI3K) pathway is a major regulator of cell and organisAkt, is observed in many human cancers. Pleckstrin homology domain leucine- rich repeat- containing protein phosphatases (PHLPP), two paralogous members of the metal- dependent protein phosphatase family, have been reported as negative regulators of Akt signaling and, therefore, tumor suppressors. However, the stoichiometry and identity of the bound metal ion(s), mechanism of action, and enzymatic specificity...
