2025

最新文章

• Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging AI翻译
  作者：Howe, Carmel L.; Zhao, Kate L. Y.; Verinaz-Jadan, Herman; Song, Pingfan; Barnes, Samuel J.; Dragotti, Pier Luigi; Foust, Amanda J.
  作者单位：Imperial College London; Imperial College London; Escuela Superior Politecnica del Litoral; University of Cambridge; Imperial College London
  摘要：Light-field microscopy (LFM) enables high-throughput functional imaging by scanlessly encoding entire volumes in single snapshots. However, LFM's computational burden and vulnerability to scattering limit its application to biological imaging. We present a light-field strategy for volumetric, scattering-mitigated neural circuit activity monitoring. A physics-based deep neural network, 2PiLnet, is trained with two-photon volumes and one-photon light fields. Light-field videos of jGCaMP8f-expres...
• Migration and the persistence of violence AI翻译
  作者：Larsen, Martin Vines; Lenz, Gabriel S.; Mikkelborg, Anna
  作者单位：Aarhus University; University of California System; University of California Berkeley; Colorado State University System; Colorado State University Fort Collins
  摘要：Using data on millions of internal US migrants, we document that historical homicide rates follow migrants around the United States. Individuals born in historically safe states remain safer wherever they go, while individuals born in historically dangerous states face a greater risk, including from police violence. This pattern holds across demographic characteristics such as age, gender, and marital status, across migrant groups with different average levels of education, income, and even wh...
• Single-molecule views of chromatin accessibility and structure during photomorphogenesis AI翻译
  作者：Li, Lei; Chen, Guanyu; Zhu, Guangquan; Wu, Jili; Kui, Xinglong; Zhang, Zihui; Feng, Lingyang; Huang, Minghan; Hua, Wenbo; Qu, Zhipeng; Zou, Lina; Lu, Changmei; Zhong, Bojian; He, Hang; Deng, Xing Wang; Sun, Linhua
  作者单位：Nanjing Normal University; Peking University; Peking University
  摘要：The dynamic organization of chromatin governs gene expression by regulating DNA accessibility. In plants, light not only initiates photomorphogenesis but also reshapes higher-order chromatin architecture. However, the limited resolution of current techniques impedes investigation of chromatin dynamics at the single-molecule level. Here, we applied Fiber-seq, a long-read, single-molecule chromatin profiling method, to construct near-nucleotide resolution maps of chromatin accessibility, nucleos...
• Genetic testing predicts appearance but not behavior in dogs AI翻译
  作者：Lord, Kathryn A.; Sohrab, Vista; Bryc, Kasia; White, Michelle E.; Kenney, Brittney; Pirovich, Kathleen Morrill; Chen, Frances L.; Karlsson, Elinor K.
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：Genetic tests for behavioral and personality traits in dogs are now being marketed to pet owners, but their predictive accuracy has not been validated. To evaluate the reliability of such tests, we analyzed data from Darwin's Ark, a community science initiative that includes over 3,000 dogs with both genetic data and individual- level behavioral phenotypes. None of the candidate variants had significant associations or predictive power for behavioral traits as previously reported. However, we ...
• Unmeasured prior viability selection resolves the paradox of stasis for body size in wild Soay sheep AI翻译
  作者：Mittell, Elizabeth A.; Pemberton, Josephine M.; Kruuk, Loeske E. B.; Morrissey, Michael B.
  作者单位：University of Edinburgh; University of St Andrews
  摘要：The estimation of natural selection is used to understand ecological and evolutionary processes in wild populations and is often used to predict change. However, the direct application of quantitative genetic methods, originally developed in animal breeding, has been less successful in the wild; in particular, predictions of evolutionary change are often made that are not observed. This misprediction, known as the paradox of stasis, can arise due to bias in estimates of selection via nonrandom...
• Brain- wide mapping of developmental trajectories of cerebellar efferent projections AI翻译
  作者：Murcia-Ramon, Raquel; Riva, Martina; Munoz-Cobos, Sergio; Arzalluz-Luque, Angeles; Moreno-Bravo, Juan Antonio
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
  摘要：Long-range cerebellar outputs are critical for shaping brain-wide functional architecture, influencing motor, cognitive, and affective domains. Proper cerebellar development and its efferent circuits are essential for brain maturation, and disruptions in these pathways have been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. However, despite the early developmental onset, the spatiotemporal dynamics of cerebellar connectivity remain largely unkn...
• Scientific standards suffer from misrepresenting past work AI翻译
  作者：Gonzalez-Bailon, Sandra; Lazer, David
  作者单位：University of Pennsylvania; Northeastern University
• Morphological and genomic responses to hurricanes arise and persist during a biological invasion AI翻译
  作者：Kolbe, Jason J.; Giery, Sean T.; Petherick, Ansley S.; Losos, Jonathan B.; Bock, Dan G.
  作者单位：University of Rhode Island; University System of Ohio; Ohio University; Washington University (WUSTL); Washington University (WUSTL); Griffith University
  摘要：Hurricanes can be a source of strong, episodic natural selection, especially for coastal and island populations. In Anolis lizards, selection favors morphological traits that enhance clinging performance under hurricane-force winds. However, we know little about the longer-term persistence of morphological and genomic responses to these pulse-like events. To address this limitation, we capitalized on the well-documented history of hurricanes and spread of the invasive brown anole lizard, Anoli...
• Perception of own centrality in social networks AI翻译
  作者：Kovarik, Jaromir; Ozaita, Juan; Sanchez, Angel; Branas-Carza, Pablo
  作者单位：University of Basque Country; University of West Bohemia Pilsen; Universidad Carlos III de Madrid; Universidad Carlos III de Madrid; University of Zaragoza; Universidad Loyola Andalucia
  摘要：This study explores how individuals perceive their social networks, with a focus on their own positioning. Using experimental methods and network analysis, we show that people have a limited understanding of their social standing in terms of popularity (in-degree) and centrality. Few participants accurately estimate their popularity, and even fewer correctly identify their decile of centrality. A similar pattern emerges for their perceptions of the most popular and central individuals, but we ...
• Longitudinal transformation of mitochondrial metabolism during neurogenesis AI翻译
  作者：Lim, Donghoon; Park, Sewon; Lee, Jong Seung; Gwon, Hyo Jin; Nam, Yunwoo; Choi, Suhyuk; Kim, Jongwon; Kim, Yeonsu; Park, Geonwoo; Pyun, Woo Yang; Park, Hyun Woo; Cho, Seung- Woo; Ahn, Hyun S.
  作者单位：Yonsei University; Yonsei University; Yonsei University; Institute for Basic Science - Korea (IBS); Yonsei University
  摘要：Neural stem cells (NSCs) are valuable in the quest to conquer neurodegenerative diseases due to their capability to reconstruct the damaged neuronal networks. However, deep understanding of the intercellular signaling mechanism controlling the lineage and fate of the stem cells is required before potential clinical applications. Here, we applied nondestructive and label- free electrochemical methods for the longitudinal tracking of NSC respiratory metabolism. Sharp change in the oxygen utiliza...