-
作者：Joshi, Nitin; Yan, Jing; Dang, Mickael; Slaughter, Kai; Wang, Yufeng; Wu, Dana; Ung, Trevor; Bhingaradiya, Nutan; Pandya, Virja; Chen, Mu Xian; Kaur, Shahdeep; Bhagchandani, Sachin; Alfassam, Haya A.; Joseph, John; Gao, Jingjing; Dewani, Mahima; Chu, Rachel Wai Chun; Yip, Ryan Chak Sang; Weldon, Eli; Shah, Purna; Pisal, Nishkal Dhiraj; Shukla, Chetan; Sherman, Nicholas E.; Luo, James N.; Conway, Thomas; Eickhoff Jr, James P.; Botelho, Luis; Alhasan, Ali H.; Karp, Jeffrey M.; Ermann, Joerg
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University
摘要：Intra-articular delivery of disease-modifying osteoarthritis drugs (DMOADs) is likely to be most effective in the early stages of post-traumatic osteoarthritis (PTOA), when symptoms are minimal, and patients remain physically active. To ensure effective therapy, DMOAD delivery systems therefore must withstand repeated mechanical loading without altering the kinetics of drug release. While soft materials are typically preferred for DMOAD delivery, mechanical loading can compromise their structu...
-
作者：Li, Chenglei; Burdick, Ryan C.; Siddiqui, Rokeya; Janaka, Sanath Kumar; Hsia, Ru-ching; Hu, Wei-Shau; Pathak, Vinay K.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
摘要：Lenacapavir (GS- 6207; LEN) is a potent HIV- 1 capsid inhibitor approved for treating multidrug- resistant infection. LEN binds to a hydrophobic pocket between neighboring capsid (CA) proteins in hexamers and stabilizes the capsid lattice, but its effect on HIV- 1 capsids is not fully understood. Here, we labeled HIV- 1 capsids with green fluorescent protein fused to CA (GFP- CA) or a fluid- phase GFP content marker (cmGFP) to assess LEN's impact on HIV- 1 capsids. HIV- 1 cores labeled with GF...
-
作者：Rosen, Matthew C.; Freedman, David J.
作者单位：University of Chicago; University of Chicago
摘要：Humans and other animals are adept at learning to perform cognitively demanding behavioral tasks. Neurophysiological recordings in nonhuman primates during such tasks find that the requisite cognitive variables are encoded strongly in core oculomotor brain regions. Here, we assembled a large dataset-11 monkeys performing an abstract visual categorization task, surveyed across more than 1,000 neural recording sessions- to reveal that this produces a robust but uninstructed behavioral tell, obse...
-
作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Ren, Jia-Yi; Zhu, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu-Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan-Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo-Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
-
作者：Gervais, Will M.; McKay, Ryan T.; Brown-Iannuzzi, Jazmin L.; Ross, Robert M.; Pennycook, Gordon; Jong, Jonathan; Lanman, Jonathan A.
作者单位：Brunel University; University of London; Royal Holloway University London; University of Virginia; Macquarie University; Cornell University; Coventry University; Queens University Belfast
摘要：We find evidence of belief in belief-intuitive preferences for religious belief over atheism, even among atheist participants-across eight comparatively secular countries. Religion is a cross-cultural human universal, yet explicit markers of religiosity have rapidly waned in large parts of the world in recent decades. We explored whether intuitive religious influence lingers, even among nonbelievers in largely secular societies. We adapted a classic experimental philosophy task to test for thi...
-
作者：Tian, Zhong; Wang, Kou; Guo, Shuang; Li, Jia - Xu; King-Jones, Kirst; Zhu, Fen; Liu, Wen; Wang, Xiao-Ping
作者单位：Huazhong Agricultural University; Chengdu University of Traditional Chinese Medicine; University of Alberta
摘要：Diapause, a developmental arrest mechanism, helps animals to survive seasonal changes via endocrine regulation. While obligate diapause is genetically programmed, facultative diapause is typically triggered by environmental cues such as photoperiod. In insects, this often leads to reproductive diapause characterized by reduced juvenile hormone (JH) signaling, resulting in ovarian arrest and lipid accumulation. However, the molecular link between photoperiod and hormonal control remains poorly ...
-
作者：Mathew, Anand; Kulkarni, Yashashree
作者单位：University of Houston System; University of Houston
摘要：Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as the minimum threshold for detection of electrical signals by cells. However, there is compelling experimental evidence that the minimum electric field sensed by certain cells and organisms is many orders of magnitude weaker than the thermal electrical noise limit estimated purely under equilibrium considerations...
-
作者：Song, Zhenhao; Cookmeyer, Tessa; Balents, Leon
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Canadian Institute for Advanced Research (CIFAR)
摘要：We study the driven-dissipative Bose-Hubbard model with an all-to-all hopping term in the system Hamiltonian, while subject to incoherent pumping and decay from the environment. This system is naturally probed in several recent experiments on excitons in WS2/WSe2 moir & eacute; systems, as well as quantum simulators. By positing a particular form of coupling to the environment, we derive the Lindblad jump operators and show that, in certain limits, the system admits a closed-form expression fo...
-
作者：Zhaguparov, Daniiar; Zhao, Meng; Sekar, Rohith Vedhthaanth; Woodside, Michael T.
作者单位：University of Alberta; University of Alberta; University of Alberta; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
摘要：Some viruses counter host-cell efforts to digest invading viral RNA by using special structures resistant to host RNases, known as exoribonuclease-resistant RNAs (xrRNAs). xrRNAs typically form an unusual fold with the 5 '-end threaded through a ring consisting of a multihelix junction closed by a pseudoknot. By using single-molecule force spectroscopy (SMFS), we previously showed that a Zika virus xrRNA is extremely rigid mechanically, withstanding very high forces, and that this mechanical r...
-
作者：LiWang, Andy; Orban, John
作者单位：University of California System; University of California Merced; University of California System; University of California Merced; University System of Maryland; Universities at Shady Grove; University of Maryland Baltimore; University System of Maryland; University of Maryland College Park
摘要：Metamorphic proteins switch reversibly between two differently folded states under a variety of environmental conditions. Their identification and prediction are gaining attention, but the fundamental physicochemical basis for fold switching remains poorly understood. In this Perspective article, we address this problem by surveying the landscape of well-characterized metamorphic proteins and noting that a significant fraction of them display temperature sensitivity. We then make the case that...
