2025

最新文章

• The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant AI翻译
  作者：Gonzalez-Delgado, Javier; Mier, Pablo; Bernado, Pau; Neuvial, Pierre; Cortes, Juan
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Rennes; Ecole Nationale de la Statistique et de l'Analyse de l'Information (ENSAI); Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); Universite de Toulouse (EPE); Centre National de la Recherche Scientifique (CNRS); Institut National des Sciences Appliquees de Toulouse; CNRS - National Institute for Mathematical Sciences (INSMI); Communaute d'universites et etablissements de Toulouse (Comue); Centre National de la Recherche Scientifique (CNRS)
  摘要：The correlation between synonymous codon usage and secondary structure in translated proteins has been widely demonstrated. This usage plays a capital role in tuning translational rates and protein folding kinetics, indirectly influencing multiple Nat. Commun. 13, 2815 (2022).] suggests that the translated synonymous codon influences the (tp, ) dihedral angles within secondary structure elements. If true, this conclusion would have strong consequences in several scientific fields, including st...
• The CARD14sh-BCL10-MALT 1 complex regulates MAVS- mediated antiviral response in keratinocytes AI翻译
  作者：Zerillo, Lucrezia; Zotti, Tiziana; Tutela, Angelapia; Madera, Jessica Raffaella; Grasso, Gabriella; Vito, Pasquale; Stilo, Romania
  作者单位：University of Sannio
  摘要：The Mitochondrial Antiviral Signaling Protein (MAVS) is a key adaptor in antiviral immunity, mediating type I interferon responses downstream of RIG1 and TLR3. While MAVS regulation is essential for antiviral defense, its modulation in keratinocytes is poorly understood. Here, we examine the role of the CARD14-BCL10-MALT1 (CBM) complex, a skin-specific signaling module, in controlling MAVS-dependent antiviral responses. We identify CARD14short as a dual regulator that activates NF-kappa B whil...
• A unifying principle for multispecies coexistence under resource fluctuations AI翻译
  作者：Richardson, James A.; Engelstaedter, Jan; Letten, Andrew D.
  作者单位：University of Queensland
  摘要：Resource fluctuations are ubiquitous in nature and yet are generally assumed to play a limited role in the maintenance of biodiversity. We challenge this assumption by analyzing resource competition dynamics under conditions where prevailing theory does not hold. We show that multispecies coexistence can be sustained when species are able to specialize on different temporal patterns of resource variability, including the asymmetries and periodic extremes commonly observed in natural systems. W...
• Reflection and refraction of directrons at the interface AI翻译
  作者：Tang, Xing-Zhou; Li, Chao-Yi; Huang, Zhi-Jun; Zhao, Jia-Hui; Chen, Yu-Xi; Abbott, Nicholas L.; de Pablo, Juan J.; Lu, Yan-Qing; Li, Bing-Xiang
  作者单位：Nanjing University of Posts & Telecommunications; Nanjing University of Posts & Telecommunications; University of Chicago; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Cornell University; United States Department of Energy (DOE); Argonne National Laboratory; New York University; New York University Tandon School of Engineering
  摘要：Reflection and refraction are ubiquitous phenomena with extensive applications, yet minimizing energy loss and information distortion during these processes remains a significant challenge. This study examines the behavior of structurally stable solitons, known as directrons, in nematic liquid crystals interacting with an interface where the director field orientation changes, despite identical physical properties, external potentials, and boundary anchoring in the two regions. During reflecti...
• Jund orchestrates cis- regulatory element dynamics to facilitate endothelial- to- hematopoietic transition AI翻译
  作者：Guo, Jiani; Liu, Mengyao; Liu, Feng; Wang, Lu
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Zoology, CAS
  摘要：The tightly controlled spatiotemporal expression of developmental genes depends on the concerted action of cis-regulatory elements (CREs) and transcription factors (TFs) to ensure cell fate decisions. Endothelial-to-hematopoietic transition (EHT) is a cell fate transition process by which endothelial cells acquire hematopoietic identity and become hemogenic endothelial cells (HECs) and then hematopoietic stem and progenitor cells, but the underlying CRE network dynamics and its regulation by T...
• Summer solstice optimizes the thermal growing season AI翻译
  作者：Van der Meersch, Victor; Wolkovich, E. M.
  作者单位：University of British Columbia; Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier
  摘要：Multiple studies have recently proposed the summer solstice as a universal cue for major plant physiological processes. While this would have strong implications for fundamental plant biology and climate change forecasting, we currently have no clear mechanisms to explain the emergence and importance of solstice as a cue. Here, we analyze temperature accumulation patterns in relation to the summer solstice across Europe and North America-in past, historical, and projected future climates. We s...
• Rhomboid-mediated cleavage of the immune receptor XA21 protects grain set and male fertility in rice AI翻译
  作者：Vergish, Satyam; Huang, Xiaoen; Zhang, Guiyun; Franceschi, Beatriz de Toledo; Li, Jian-Liang; Wu, Xiao-Xia; Nuraj, Joana; Huguet-Tapia, Jose C.; Parajuli, Apekshya; Chen, Xiuhua; Shekhar, Ritu; Liu, Dali; Xiao, Wu-Ming; Dou, Shijuan; Liu, Guo-zhen; Goss, Erica M.; Pi, Liya; Chen, Sixue; Koch, Karen E.; Song, Wen- Yuan
  作者单位：State University System of Florida; University of Florida; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); State University System of Florida; University of Florida; Hebei Agricultural University; State University System of Florida; University of Florida; Tulane University; University of Mississippi; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Yangzhou University; State University System of Florida; Florida International University; Heilongjiang University; South China Agricultural University
  摘要：To maintain growth and to successfully reproduce, organisms must protect key functions in specific tissues, particularly when countering pathogen invasion using internal defensive proteins that may disrupt their own developmental processes. The rice immune receptor XA21 confers race-specific resistance against Xanthomonas oryzae pv. oryzae, which causes the deadly disease bacterial leaf blight. Here, we demonstrate that XA21 is cleaved by the rhomboid-like protease OsRBL3b, likely within its t...
• Carbon and oxygen isotope evidence for a protoplanetary disk origin of organic solids in meteorites AI翻译
  作者：Lawrence, William M.; Blake, Geoffrey A.; Eiler, John
  作者单位：California Institute of Technology
  摘要：Macromolecular organic solids found in primitive meteorites were the main source of carbon delivered to forming planets in the early Solar System. However, the conditions under which this material formed and its subsequent incorporation into growing planetesimals remains a subject of vigorous debate. Here, we show that C isotope variations among these organics in most carbonaceous chondrites are strongly correlated with mass-independent O isotope anomalies exhibited by their host meteorites. A...
• Label-free high-throughput live-cell sorting of genome-wide random mutagenesis libraries for metabolic traits by Raman flow cytometry AI翻译
  作者：Wang, Xixian; Wang, Sen; Diao, Zhidian; Hou, Xibao; Gong, Yanhai; Sun, Qing; Zhang, Jiaping; Ren, Lihui; Li, Yuandong; Ji, Yuetong; Shen, Wei; Yin, Yifeng; Huang, Shi; Song, Xiaojin; Cui, Qiu; Feng, Yingang; Xu, Jian; Ma, Bo
  作者单位：Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Hong Kong
  摘要：A full spontaneous single-cell Raman spectrum captures the metabolic phenome in a label-free and noninvasive manner. However, Raman-activated cell sorting (RACS) of rare target cells from highly heterogeneous systems has remained largely conceptual. Here, we present a positive dielectrophoresis-induced deterministic lateral displacement (pDEP-DLD)-based RACS (pDEP-DLD-RACS), in which a modulated pDEP-DLD force is applied to focus, trap, and functionally sort fast-moving single cells in a wide ...
• Forecasting range shifts of dioecious plants under climate change AI翻译
  作者：Moutouama, Jacob K.; Compagnoni, Aldo; Miller, Tom E. X.
  作者单位：Rice University; Martin Luther University Halle Wittenberg; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
  摘要：Global climate change has triggered an urgent need for predicting the reorganization of Earth's biodiversity. For dioecious species (those with separate sexes), it is unclear how commonly unique climate sensitivities of females and males could influence projections for species-level responses to climate change. We developed demographic models of range limitation, parameterized from geographically distributed common garden experiments, with females and males of a dioecious grass species (Poa ar...