-
作者：[Anonymous]
-
作者：Guzior, Douglas V.; Okros, Maxwell; Shivel, Madison; Armwald, Bruin; Bridges, Christopher; Fu, Yousi; Martin, Christian; Schilmiller, Anthony L.; Miller, Wendy M.; Ziegler, Kathryn M.; Sims, Matthew D.; Maddens, Michael E.; Graham, Stewart F.; Hausinger, Robert P.; Quinn, Robert A.
作者单位：Michigan State University; Michigan State University; Michigan State University; Michigan State University College of Osteopathic Medicine; Michigan State University; Oakland University
摘要：Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome because of their antimicrobial properties1-4. Here we identify the enzyme responsible for a mechanism of BA metabolism by the gut microbiota involving amino acid conjugation to the acyl-site of BAs, thus producing a diverse suite of microbially conjugated bile acids (MCBAs). We show that this transformation is mediated by acyltransferase activity o...
-
作者：Wong, Carissa
摘要：Study of more than 70,000 people suggests that trust levels vary among countries and are linked to political orientation.
-
作者：Grossman, Daniel
摘要：Fed up with a lack of political progress in solving the climate problem, some researchers are becoming activists to slow global warming.
-
作者：[Anonymous]
摘要：Efforts to establish Africa's first continent-wide science fund have struggled. More needs to be done to get it up and running
-
作者：Kasen, Daniel
作者单位：University of California System; University of California Berkeley
摘要：The afterglow of a long burst of gamma-rays suggests that the events leading to these explosions can be sizeable sources of some of the Universe's rare isotopes - and that classifications of gamma-ray bursts are too simplistic.
-
作者：Lu, Zhengguang; Han, Tonghang; Yao, Yuxuan; Reddy, Aidan P.; Yang, Jixiang; Seo, Junseok; Watanabe, Kenji; Taniguchi, Takashi; Fu, Liang; Ju, Long
作者单位：Massachusetts Institute of Technology (MIT); National Institute for Materials Science; National Institute for Materials Science
摘要：The fractional quantum anomalous Hall effect (FQAHE), the analogue of the fractional quantum Hall effect(1) at zero magnetic field, is predicted to exist in topological flat bands under spontaneous time-reversal-symmetry breaking(2,3,4,5,6). The demonstration of FQAHE could lead to non-Abelian anyons that form the basis of topological quantum computation(7,8,9). So far, FQAHE has been observed only in twisted MoTe2 at a moire filling factor v > 1/2 (refs. (10,11,12,13)). Graphene-based moire s...
-
作者：Nagel, Katherine
作者单位：New York University
摘要：Studies reveal how neuronal populations in the fruit fly brain work together to compare the direction of a goal with the direction that the fly is facing, and convert this into a signal that steers the fly towards its target.
-
作者：Rimal, Bipin; Collins, Stephanie L.; Tanes, Ceylan E.; Rocha, Edson R.; Granda, Megan A.; Solanki, Sumeet; Hoque, Nushrat J.; Gentry, Emily C.; Koo, Imhoi; Reilly, Erin R.; Hao, Fuhua; Paudel, Devendra; Singh, Vishal; Yan, Tingting; Kim, Min Soo; Bittinger, Kyle; Zackular, Joseph P.; Krausz, Kristopher W.; Desai, Dhimant; Amin, Shantu; Coleman, James P.; Shah, Yatrik M.; Bisanz, Jordan E.; Gonzalez, Frank J.; Vanden Heuvel, John P.; Wu, Gary D.; Zemel, Babette S.; Dorrestein, Pieter C.; Weinert, Emily E.; Patterson, Andrew D.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of North Carolina; East Carolina University; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Diego; University of California System; University of California San Diego; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; University of Pennsylvania; Virginia Polytechnic Institute & State University
摘要：Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes1-6; however, the bacterial gene(s) responsible for their production remain unknown. Herein, we report that bile salt hydrolase (BSH) possesses dual functions in bile acid metabolism. Specifically, we identified a previously unknown role for BSH as an amine N-acyltransferase that conjugates amines to bile acids, thus forming bacterial bile acid amidates (BBAAs). To char...
-
作者：Wu, Yingju; Zhang, Yang; Wang, Xiaoyu; Hu, Wentao; Zhao, Song; Officer, Timothy; Luo, Kun; Tong, Ke; Du, Congcong; Zhang, Liqiang; Li, Baozhong; Zhuge, Zewen; Liang, Zitai; Ma, Mengdong; Nie, Anmin; Yu, Dongli; He, Julong; Liu, Zhongyuan; Xu, Bo; Wang, Yanbin; Zhao, Zhisheng; Tian, Yongjun
作者单位：Yanshan University; Tsinghua University; Shaanxi University of Technology; University of Chicago; Yanshan University
摘要：Moire superlattices formed by twisted stacking in van der Waals materials have emerged as a new platform for exploring the physics of strongly correlated materials and other emergent phenomena1-5. However, there remains a lack of research on the mechanical properties of twisted-layer van der Waals materials, owing to a lack of suitable strategies for making three-dimensional bulk materials. Here we report the successful synthesis of a polycrystalline boron nitride bulk ceramic with high room-t...
