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作者：Schnitzler, Gavin R.; Kang, Helen; Fang, Shi; Angom, Ramcharan S.; Lee-Kim, Vivian S.; Ma, X. Rosa; Zhou, Ronghao; Zeng, Tony; Guo, Katherine; Taylor, Martin S.; Vellarikkal, Shamsudheen K.; Barry, Aurelie E.; Sias-Garcia, Oscar; Bloemendal, Alex; Munson, Glen; Guckelberger, Philine; Nguyen, Tung H.; Bergman, Drew T.; Hinshaw, Stephen; Cheng, Nathan; Cleary, Brian; Aragam, Krishna; Lander, Eric S.; Finucane, Hilary K.; Mukhopadhyay, Debabrata; Gupta, Rajat M.; Engreitz, Jesse M.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Stanford University; Mayo Clinic; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Dartmouth College; Stanford University; Stanford University; Stanford Cancer Institute; Boston University; Boston University; Boston University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford University
摘要：Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1-3. For some diseases, a successful strategy has been to look for cases in which multiple GWAS loci contain genes that act in the same biological pathway1-6. However, our knowledge of which genes act in which pathways is incomplete, particularly for cell-type-specific pathways or understudied genes. Here we introduce a method to connect GWAS variants to functions. This method li...
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作者：Castelvecchi, Davide
摘要：Voisin won this year's Crafoord Prize in Mathematics for research inspired by string theory, and work on a million-dollar unsolved problem.
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作者：Neutze, Richard
作者单位：University of Gothenburg
摘要：Cutting-edge X-ray sources have enabled the structural dynamics of proteins to be tracked during biochemical processes, but the findings have been questioned. Two experts discuss the implications of a study that digs into this issue.
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作者：Pells, Rachael; Korngut, Phil
作者单位：California Institute of Technology
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作者：Saether, Bernt-Erik
作者单位：Norwegian University of Science & Technology (NTNU)
摘要：A long-term fish experiment reveals how a mechanism called density dependence, in which the population growth rate slows as the number of individuals rises, affects population dynamics on time scales relevant for ecology and evolution.
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作者：[Anonymous]
摘要：Promises to safeguard biodiversity need to be translated into money in the bank.
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作者：Dickson, C. F.; Hertel, S.; Tuckwell, A. J.; Li, N.; Ruan, J.; Al-Izzi, S. C.; Ariotti, N.; Sierecki, E.; Gambin, Y.; Morris, R. G.; Towers, G. J.; Bocking, T.; Jacques, D. A.
作者单位：University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of Queensland; University of London; University College London
摘要：HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central channel of the nuclear pore is composed of intrinsically disordered nucleoporin domains enriched in phenylalanine-glycine (FG) dipeptides. Through mult...
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作者：Paolo, Fernando S.; Kroodsma, David; Raynor, Jennifer; Hochberg, Tim; Davis, Pete; Cleary, Jesse; Marsaglia, Luca; Orofino, Sara; Thomas, Christian; Halpin, Patrick
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作者：Haakonsen, Diane L.; Heider, Michael; Ingersoll, Andrew J.; Vodehnal, Kayla; Witus, Samuel R.; Uenaka, Takeshi; Wernig, Marius; Rape, Michael
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; Stanford University; Stanford University; University of California System; University of California Berkeley
摘要：Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts organismal health1-3. How stress responses are turned off at the right time and place remains poorly understood. Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress. Crucial to this process is the silencing factor of the integrated stress response (SIFI), a l...
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作者：Liu, Haimeng; Liu, Jianguo
作者单位：Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Michigan State University
