2024

最新文章

• Smoking changes adaptive immunity with persistent effects AI翻译
  作者：Saint-Andre, Violaine; Charbit, Bruno; Biton, Anne; Rouilly, Vincent; Posseme, Celine; Bertrand, Anthony; Rotival, Maxime; Bergstedt, Jacob; Patin, Etienne; Albert, Matthew L.; Quintana-Murci, Lluis; Duffy, Darragh
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Karolinska Institutet; Karolinska Institutet; Universite PSL; College de France
  摘要：Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability1-6. However, the variables that drive such differences in cytokine secretion-a crucial component of the host response to immune challenges-remain poorly defined. Here we investigated 136 variables and identified smoking, cytomegalovirus latent infection and body mass index as major contributors to variability in cytokine response, with effects of comparable mag...
• Super-speedy sequencing puts genomic diagnosis in the fast lane AI翻译
  作者：Eisenstein, Michael
• Great 'Stone Age' wall discovered in Baltic Sea AI翻译
  作者：[Anonymous]
  摘要：Megastructure stretching nearly 1 kilometre long is probably one of the oldest known hunting aids on Earth.
• How my academic sabbatical offered a chance to hit the restart button on my career AI翻译
  作者：Brown, Brandon
  作者单位：University of California System; University of California Riverside
  摘要：Time away from his daily responsibilities taught Brandon Brown that he is replaceable - and that's a good thing.
• China conducts first nationwide review of retractions and research misconduct AI翻译
  作者：Mallapaty, Smriti
  摘要：Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 retractions with Chinese co-authors.
• The nuclear factor ID3 endows macrophages with a potent anti-tumour activity AI翻译
  作者：Deng, Zihou; Loyher, Pierre-Louis; Lazarov, Tomi; Li, Li; Shen, Zeyang; Bhinder, Bhavneet; Yang, Hairu; Zhong, Yi; Alberdi, Araitz; Massague, Joan; Sun, Joseph C.; Benezra, Robert; Glass, Christopher K.; Elemento, Olivier; Iacobuzio-Donahue, Christine A.; Geissmann, Frederic
  作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; City University of New York (CUNY) System; University of California System; University of California San Diego; University of California System; University of California San Diego; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Macrophage activation is controlled by a balance between activating and inhibitory receptors1-7, which protect normal tissues from excessive damage during infection8,9 but promote tumour growth and metastasis in cancer7,10. Here we report that the Kupffer cell lineage-determining factor ID3 controls this balance and selectively endows Kupffer cells with the ability to phagocytose live tumour cells and orchestrate the recruitment, proliferation and activation of natural killer and CD8 T lymphoi...
• Conformational ensembles of the human intrinsically disordered proteome AI翻译
  作者：Tesei, Giulio; Trolle, Anna Ida; Jonsson, Nicolas; Betz, Johannes; Knudsen, Frederik E.; Pesce, Francesco; Johansson, Kristoffer E.; Lindorff-Larsen, Kresten
  作者单位：University of Copenhagen
  摘要：Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across proteomes in all kingdoms of life, help to shape biological functions and are involved in numerous diseases. IDRs populate a diverse set of transiently formed structures and defy conventional sequence-structure-function relationships1. Developments in protein science have made it possible to predict the three-dimensional structures of folded proteins at the proteome scale2. By contrast, there is a lack of k...
• Smoking's lasting effect on the immune system AI翻译
  作者：Luo, Yang; Stent, Simon
  作者单位：University of Oxford; Kennedy Institute for Rheumatology
  摘要：It emerges from a study of human cells that smoking can influence certain immune responses to the same extent as can age or genetics. Smoking can alter the immune system in ways that persist long after quitting the habit.
• The immune markers that predict who can keep SARS-CoV-2 in check AI翻译
  作者：[Anonymous]
  摘要：People infected with the virus that causes COVID-19 cleared the virus more quickly if they had high levels of certain immune cells.
• Translation selectively destroys non-functional transcription complexes AI翻译
  作者：Woodgate, Jason; Mosaei, Hamed; Brazda, Pavel; Stevenson-Jones, Flint; Zenkin, Nikolay
  作者单位：Newcastle University - UK
  摘要：Transcription elongation stalls at lesions in the DNA template1. For the DNA lesion to be repaired, the stalled transcription elongation complex (EC) has to be removed from the damaged site2. Here we show that translation, which is coupled to transcription in bacteria, actively dislodges stalled ECs from the damaged DNA template. By contrast, paused, but otherwise elongation-competent, ECs are not dislodged by the ribosome. Instead, they are helped back into processive elongation. We also show...